Gene summary |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
ENSG00000198542
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
TC | UP | 4.988579e+01 | 1.593866e+00 | 2.133964e-14 | 5.494339e-12 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
DLPFC | UP | ENST00000376162.7 | ITGBL1-201:protein_coding:ITGBL1 | 1.963419e+00 | 9.580381e-01 | 1.214950e-03 | 3.828734e-02 |
PG | UP | ENST00000376162.7 | ITGBL1-201:protein_coding:ITGBL1 | 1.969769e+00 | 2.849990e+00 | 1.421103e-05 | 6.525921e-04 |
CB | UP | ENST00000545560.6 | ITGBL1-205:protein_coding:ITGBL1 | 1.563896e+02 | 8.728318e-01 | 5.581609e-05 | 4.515713e-04 |
TC | UP | ENST00000376180.8 | ITGBL1-202:protein_coding:ITGBL1 | 1.953206e+01 | 2.577939e+00 | 4.040305e-10 | 6.188955e-08 |
TC | UP | ENST00000490242.2 | ITGBL1-204:protein_coding:ITGBL1 | 9.539743e+00 | 1.028222e+00 | 8.907848e-06 | 2.361395e-04 |
TC | UP | ENST00000618057.4 | ITGBL1-206:protein_coding:ITGBL1 | 2.540120e+00 | 2.709738e+00 | 8.599747e-04 | 8.794490e-03 |
TC | UP | ENST00000376162.7 | ITGBL1-201:protein_coding:ITGBL1 | 8.719404e+00 | 1.543634e+00 | 1.056238e-03 | 1.032342e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_1305 | chr13 | 101567719:101567845:101575424:101575546:101579287:101579427 | 101575424:101575546 |
exon_skip_165755 | chr13 | 101452667:101452931:101453883:101454100:101567699:101567845 | 101453883:101454100 |
exon_skip_73169 | chr13 | 101452675:101452931:101453883:101454100:101567699:101567713 | 101453883:101454100 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000376180 | 101453883 | 101454100 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000376180 | 101453883 | 101454100 | Frame-shift |
ENST00000376180 | 101575424 | 101575546 | In-frame |
p-ENSG00000198542_img4.png
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Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000376180 | 2511 | 494 | 101575424 | 101575546 | 684 | 805 | 155 | 195 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95965 | 155 | 195 | 24 | 494 | Chain | ID=PRO_5000054386;Note=Integrin beta-like protein 1 |
O95965 | 155 | 195 | 51 | 494 | Region | Note=Cysteine-rich tandem repeats |
O95965 | 155 | 195 | 143 | 184 | Repeat | Note=III |
O95965 | 155 | 195 | 185 | 230 | Repeat | Note=IV |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |