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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TXNL1 |
 Gene summary |
| Gene information | Gene symbol | TXNL1 | Gene ID | 9352 |
| Gene name | thioredoxin like 1 | |
| Synonyms | HEL-S-114|TRP32|TXL-1|TXNL|Txl | |
| Cytomap | 18q21.31 | |
| Type of gene | protein-coding | |
| Description | thioredoxin-like protein 132 kDa thioredoxin-related proteinepididymis secretory protein Li 114thioredoxin-related 32 kDa proteinthioredoxin-related protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TXNL1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000091164
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000587613.1 | TXNL1-205:protein_coding:TXNL1 | 2.350940e+00 | 9.561922e-01 | 1.014881e-03 | 5.229257e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TXNL1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_119156 | chr18 | 56624288:56624461:56626162:56626266:56626361:56626457 | 56626162:56626266 |
| exon_skip_174210 | chr18 | 56624288:56624461:56626162:56626266:56626361:56626456 | 56626162:56626266 |
| exon_skip_180207 | chr18 | 56626361:56626457:56638343:56639039:56651017:56651045 | 56638343:56639039 |
| exon_skip_195017 | chr18 | 56614424:56614596:56616245:56616314:56618004:56618126 | 56616245:56616314 |
| exon_skip_203812 | chr18 | 56602898:56603056:56610993:56611097:56614424:56614491 | 56610993:56611097 |
| exon_skip_277635 | chr18 | 56626361:56626457:56638343:56638505:56647449:56647535 | 56638343:56638505 |
| exon_skip_292829 | chr18 | 56638962:56639039:56647449:56647535:56651017:56651045 | 56647449:56647535 |
| exon_skip_293277 | chr18 | 56626361:56626457:56638343:56639039:56651017:56651274 | 56638343:56639039 |
| exon_skip_30155 | chr18 | 56626361:56626457:56638343:56639039:56651017:56651593 | 56638343:56639039 |
| exon_skip_39327 | chr18 | 56638359:56638505:56638962:56639039:56647449:56647535 | 56638962:56639039 |
| exon_skip_79454 | chr18 | 56610993:56611097:56614424:56614596:56616245:56616314 | 56614424:56614596 |
| exon_skip_88720 | chr18 | 56638359:56638505:56647449:56647535:56651017:56651045 | 56647449:56647535 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TXNL1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000590954 | 56638343 | 56638505 | 3UTR-3CDS |
| ENST00000590954 | 56647449 | 56647535 | 3UTR-3UTR |
| ENST00000217515 | 56610993 | 56611097 | In-frame |
| ENST00000590954 | 56610993 | 56611097 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000590954 | 56638343 | 56638505 | 3UTR-3CDS |
| ENST00000590954 | 56647449 | 56647535 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000590954 | 56638343 | 56638505 | 3UTR-3CDS |
| ENST00000590954 | 56647449 | 56647535 | 3UTR-3UTR |
| ENST00000217515 | 56614424 | 56614596 | Frame-shift |
| ENST00000590954 | 56614424 | 56614596 | Frame-shift |
| ENST00000217515 | 56616245 | 56616314 | Frame-shift |
| ENST00000590954 | 56616245 | 56616314 | Frame-shift |
| ENST00000217515 | 56610993 | 56611097 | In-frame |
| ENST00000590954 | 56610993 | 56611097 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TXNL1 |
p-ENSG00000091164_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000217515 | 6911 | 289 | 56610993 | 56611097 | 941 | 1044 | 245 | 279 |
| ENST00000590954 | 1356 | 289 | 56610993 | 56611097 | 1000 | 1103 | 245 | 279 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000217515 | 6911 | 289 | 56610993 | 56611097 | 941 | 1044 | 245 | 279 |
| ENST00000590954 | 1356 | 289 | 56610993 | 56611097 | 1000 | 1103 | 245 | 279 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O43396 | 245 | 279 | 241 | 248 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 241 | 248 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 263 | 271 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 263 | 271 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 2 | 289 | Chain | ID=PRO_0000120016;Note=Thioredoxin-like protein 1 |
| O43396 | 245 | 279 | 2 | 289 | Chain | ID=PRO_0000120016;Note=Thioredoxin-like protein 1 |
| O43396 | 245 | 279 | 115 | 285 | Domain | Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864 |
| O43396 | 245 | 279 | 115 | 285 | Domain | Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O43396 | 245 | 279 | 241 | 248 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 241 | 248 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 263 | 271 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 263 | 271 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1WWY |
| O43396 | 245 | 279 | 2 | 289 | Chain | ID=PRO_0000120016;Note=Thioredoxin-like protein 1 |
| O43396 | 245 | 279 | 2 | 289 | Chain | ID=PRO_0000120016;Note=Thioredoxin-like protein 1 |
| O43396 | 245 | 279 | 115 | 285 | Domain | Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864 |
| O43396 | 245 | 279 | 115 | 285 | Domain | Note=PITH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00864 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TXNL1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000590954 | 56647449 | 56647535 | hsa-miR-6072 | chr18:56647523-56647530 | 8mer-1a | chr18:56647510-56647530 | 160.00 | -19.70 |
| Mayo | ENST00000590954 | 56647449 | 56647535 | hsa-miR-6891-3p | chr18:56647523-56647530 | 8mer-1a | chr18:56647510-56647530 | 160.00 | -19.70 |
| MSBB | ENST00000590954 | 56647449 | 56647535 | hsa-miR-6072 | chr18:56647523-56647530 | 8mer-1a | chr18:56647510-56647530 | 160.00 | -19.70 |
| MSBB | ENST00000590954 | 56647449 | 56647535 | hsa-miR-6891-3p | chr18:56647523-56647530 | 8mer-1a | chr18:56647510-56647530 | 160.00 | -19.70 |
| ROSMAP | ENST00000590954 | 56647449 | 56647535 | hsa-miR-6072 | chr18:56647523-56647530 | 8mer-1a | chr18:56647510-56647530 | 160.00 | -19.70 |
| ROSMAP | ENST00000590954 | 56647449 | 56647535 | hsa-miR-6891-3p | chr18:56647523-56647530 | 8mer-1a | chr18:56647510-56647530 | 160.00 | -19.70 |
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SNVs in the skipped exons for TXNL1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TXNL1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TXNL1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TXNL1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TXNL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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