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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for GLP2R |
Gene summary |
Gene information | Gene symbol | GLP2R | Gene ID | 9340 |
Gene name | glucagon like peptide 2 receptor | |
Synonyms | - | |
Cytomap | 17p13.1 | |
Type of gene | protein-coding | |
Description | glucagon-like peptide 2 receptorGLP-2 receptorepididymis secretory sperm binding protein | |
Modification date | 20200313 | |
UniProtAcc | A0A384MTS7, | |
Context | - 30452417(Glucagon-Like Peptide-2 Receptor is Involved in Spatial Cognitive Dysfunction in Rats After Chronic Cerebral Hypoperfusion) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GLP2R |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
CB | UP | 1.752861e+01 | 1.048096e+00 | 3.896759e-09 | 9.986956e-08 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000458005.2 | GLP2R-203:nonsense_mediated_decay:GLP2R | 8.655804e+00 | 1.272358e+00 | 5.134302e-04 | 2.743506e-02 |
CB | UP | ENST00000262441.10 | GLP2R-201:protein_coding:GLP2R | 1.602141e+01 | 1.019311e+00 | 2.679434e-08 | 6.958662e-07 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GLP2R |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_121542 | chr17 | 9833807:9833894:9834538:9834783:9836371:9836475 | 9834538:9834783 |
exon_skip_178041 | chr17 | 9825924:9826252:9833807:9833894:9836371:9836475 | 9833807:9833894 |
exon_skip_231807 | chr17 | 9861139:9861199:9862021:9862090:9870747:9870835 | 9862021:9862090 |
exon_skip_275934 | chr17 | 9833807:9833894:9836371:9836475:9842495:9842616 | 9836371:9836475 |
exon_skip_48334 | chr17 | 9836371:9836475:9842495:9842616:9854495:9854601 | 9842495:9842616 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GLP2R |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000262441 | 9833807 | 9833894 | Frame-shift |
ENST00000262441 | 9842495 | 9842616 | Frame-shift |
ENST00000262441 | 9862021 | 9862090 | Frame-shift |
ENST00000262441 | 9836371 | 9836475 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000262441 | 9833807 | 9833894 | Frame-shift |
ENST00000262441 | 9842495 | 9842616 | Frame-shift |
ENST00000262441 | 9862021 | 9862090 | Frame-shift |
ENST00000262441 | 9836371 | 9836475 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000262441 | 9842495 | 9842616 | Frame-shift |
ENST00000262441 | 9862021 | 9862090 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for GLP2R |
p-ENSG00000065325_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000262441 | 4589 | 553 | 9836371 | 9836475 | 792 | 895 | 93 | 127 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000262441 | 4589 | 553 | 9836371 | 9836475 | 792 | 895 | 93 | 127 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95838 | 93 | 127 | 1 | 553 | Chain | ID=PRO_0000012838;Note=Glucagon-like peptide 2 receptor |
O95838 | 93 | 127 | 83 | 105 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
O95838 | 93 | 127 | 96 | 137 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
O95838 | 93 | 127 | 118 | 159 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
O95838 | 93 | 127 | 97 | 97 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
O95838 | 93 | 127 | 113 | 113 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
O95838 | 93 | 127 | 1 | 173 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95838 | 93 | 127 | 1 | 553 | Chain | ID=PRO_0000012838;Note=Glucagon-like peptide 2 receptor |
O95838 | 93 | 127 | 83 | 105 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
O95838 | 93 | 127 | 96 | 137 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
O95838 | 93 | 127 | 118 | 159 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
O95838 | 93 | 127 | 97 | 97 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
O95838 | 93 | 127 | 113 | 113 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
O95838 | 93 | 127 | 1 | 173 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in GLP2R |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for GLP2R |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GLP2R |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GLP2R |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GLP2R |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for GLP2R |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
O95838 | approved | DB00040 | Glucagon | biotech | O95838 |
O95838 | approved | DB08900 | Teduglutide | biotech | O95838 |
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RelatedDiseases for GLP2R |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |