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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for OPALIN |
 Gene summary |
| Gene information | Gene symbol | OPALIN | Gene ID | 93377 |
| Gene name | oligodendrocytic myelin paranodal and inner loop protein | |
| Synonyms | HTMP10|TMEM10|TMP10 | |
| Cytomap | 10q24.1 | |
| Type of gene | protein-coding | |
| Description | opalintransmembrane protein 10transmembrane protein TMP10 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for OPALIN |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000197430
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| CB | DOWN | 6.621971e+02 | -1.092637e+00 | 7.718917e-07 | 8.506385e-06 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000371172.8 | OPALIN-201:protein_coding:OPALIN | 5.717273e+02 | -1.121677e+00 | 1.639099e-05 | 1.603655e-04 |
| CB | DOWN | ENST00000393870.3 | OPALIN-202:protein_coding:OPALIN | 1.364511e+01 | -1.325496e+00 | 8.674070e-03 | 3.093764e-02 |
| TC | DOWN | ENST00000611913.4 | OPALIN-206:protein_coding:OPALIN | 2.654754e+02 | -2.944410e+00 | 1.069971e-06 | 4.240301e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for OPALIN |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_124588 | chr10 | 96348289:96348345:96349707:96349826:96355255:96355290 | 96349707:96349826 |
| exon_skip_129675 | chr10 | 96349707:96349826:96351378:96351410:96355255:96355290 | 96351378:96351410 |
| exon_skip_180406 | chr10 | 96348289:96348345:96349707:96349826:96351378:96351410 | 96349707:96349826 |
| exon_skip_40506 | chr10 | 96349707:96349826:96355255:96355290:96358894:96359002 | 96355255:96355290 |
| exon_skip_72048 | chr10 | 96348289:96348345:96349707:96349826:96358894:96359002 | 96349707:96349826 |
| exon_skip_99830 | chr10 | 96349707:96349826:96351378:96351410:96358894:96359002 | 96351378:96351410 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for OPALIN |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371172 | 96349707 | 96349826 | In-frame |
| ENST00000371172 | 96351378 | 96351410 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371172 | 96349707 | 96349826 | In-frame |
| ENST00000371172 | 96351378 | 96351410 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371172 | 96349707 | 96349826 | In-frame |
| ENST00000371172 | 96351378 | 96351410 | In-frame |
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Infer the effects of exon skipping event on protein functional features for OPALIN |
p-ENSG00000197430_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000371172 | 3574 | 141 | 96351378 | 96351410 | 446 | 477 | 13 | 23 |
| ENST00000371172 | 3574 | 141 | 96349707 | 96349826 | 479 | 597 | 24 | 63 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000371172 | 3574 | 141 | 96351378 | 96351410 | 446 | 477 | 13 | 23 |
| ENST00000371172 | 3574 | 141 | 96349707 | 96349826 | 479 | 597 | 24 | 63 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000371172 | 3574 | 141 | 96351378 | 96351410 | 446 | 477 | 13 | 23 |
| ENST00000371172 | 3574 | 141 | 96349707 | 96349826 | 479 | 597 | 24 | 63 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96PE5 | 13 | 23 | 1 | 24 | Alternative sequence | ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PE5 | 13 | 23 | 1 | 13 | Alternative sequence | ID=VSP_042943;Note=In isoform 2. MSFSLNFTLPANT->MRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96PE5 | 13 | 23 | 13 | 23 | Alternative sequence | ID=VSP_054892;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96PE5 | 13 | 23 | 1 | 141 | Chain | ID=PRO_0000072591;Note=Opalin |
| Q96PE5 | 13 | 23 | 14 | 14 | Glycosylation | Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96PE5 | 13 | 23 | 1 | 29 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 1 | 24 | Alternative sequence | ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PE5 | 24 | 63 | 1 | 141 | Chain | ID=PRO_0000072591;Note=Opalin |
| Q96PE5 | 24 | 63 | 1 | 29 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 51 | 141 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 30 | 50 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96PE5 | 13 | 23 | 1 | 24 | Alternative sequence | ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PE5 | 13 | 23 | 1 | 13 | Alternative sequence | ID=VSP_042943;Note=In isoform 2. MSFSLNFTLPANT->MRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96PE5 | 13 | 23 | 13 | 23 | Alternative sequence | ID=VSP_054892;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96PE5 | 13 | 23 | 1 | 141 | Chain | ID=PRO_0000072591;Note=Opalin |
| Q96PE5 | 13 | 23 | 14 | 14 | Glycosylation | Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96PE5 | 13 | 23 | 1 | 29 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 1 | 24 | Alternative sequence | ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PE5 | 24 | 63 | 1 | 141 | Chain | ID=PRO_0000072591;Note=Opalin |
| Q96PE5 | 24 | 63 | 1 | 29 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 51 | 141 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 30 | 50 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96PE5 | 13 | 23 | 1 | 24 | Alternative sequence | ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PE5 | 13 | 23 | 1 | 13 | Alternative sequence | ID=VSP_042943;Note=In isoform 2. MSFSLNFTLPANT->MRM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96PE5 | 13 | 23 | 13 | 23 | Alternative sequence | ID=VSP_054892;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q96PE5 | 13 | 23 | 1 | 141 | Chain | ID=PRO_0000072591;Note=Opalin |
| Q96PE5 | 13 | 23 | 14 | 14 | Glycosylation | Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q96PE5 | 13 | 23 | 1 | 29 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 1 | 24 | Alternative sequence | ID=VSP_046290;Note=In isoform 3. MSFSLNFTLPANTTSSPVTGGKET->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PE5 | 24 | 63 | 1 | 141 | Chain | ID=PRO_0000072591;Note=Opalin |
| Q96PE5 | 24 | 63 | 1 | 29 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 51 | 141 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q96PE5 | 24 | 63 | 30 | 50 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in OPALIN |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for OPALIN |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for OPALIN |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for OPALIN |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for OPALIN |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for OPALIN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OPALIN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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