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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIP4 |
 Gene summary |
| Gene information | Gene symbol | TRIP4 | Gene ID | 9325 |
| Gene name | thyroid hormone receptor interactor 4 | |
| Synonyms | ASC-1|ASC1|HsT17391|MDCDC|SMABF1|ZC2HC5 | |
| Cytomap | 15q22.31 | |
| Type of gene | protein-coding | |
| Description | activating signal cointegrator 1TR-interacting protein 4TRIP-4thyroid receptor-interacting protein 4zinc finger, C2HC5-type | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 24495969(Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIP4 | GO:0006355 | regulation of transcription, DNA-templated | 12077347 |
| TRIP4 | GO:0030520 | intracellular estrogen receptor signaling pathway | 25219498 |
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Gene structures and expression levels for TRIP4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000103671
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000557834.5 | TRIP4-202:lncRNA:TRIP4 | 1.661161e+01 | 8.521165e-01 | 3.890340e-11 | 2.894381e-09 |
| CB | DOWN | ENST00000560475.1 | TRIP4-209:protein_coding:TRIP4 | 1.794445e+01 | -2.599685e+00 | 2.080345e-04 | 1.376003e-03 |
| TC | DOWN | ENST00000560475.1 | TRIP4-209:protein_coding:TRIP4 | 1.059407e+01 | -2.364315e+00 | 7.607208e-04 | 8.005639e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIP4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103969 | chr15 | 64409718:64409828:64414085:64414211:64418541:64418728 | 64414085:64414211 |
| exon_skip_125323 | chr15 | 64393946:64394115:64395398:64395531:64397606:64397818 | 64395398:64395531 |
| exon_skip_192474 | chr15 | 64395398:64395531:64397606:64397818:64400743:64400821 | 64397606:64397818 |
| exon_skip_211417 | chr15 | 64400743:64400821:64406330:64406459:64409613:64409684 | 64406330:64406459 |
| exon_skip_229784 | chr15 | 64387862:64388048:64393341:64393434:64393946:64394026 | 64393341:64393434 |
| exon_skip_239922 | chr15 | 64409718:64409828:64414085:64414211:64418541:64418727 | 64414085:64414211 |
| exon_skip_278119 | chr15 | 64424115:64424155:64425540:64425631:64445006:64445108 | 64425540:64425631 |
| exon_skip_51551 | chr15 | 64425540:64425631:64445006:64445108:64454997:64455236 | 64445006:64445108 |
| exon_skip_7699 | chr15 | 64409718:64409828:64418541:64418728:64424031:64424155 | 64418541:64418728 |
| exon_skip_87003 | chr15 | 64394007:64394115:64395398:64395531:64397606:64397735 | 64395398:64395531 |
| exon_skip_90089 | chr15 | 64409780:64409828:64414085:64414211:64418541:64418728 | 64414085:64414211 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIP4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261884 | 64395398 | 64395531 | Frame-shift |
| ENST00000261884 | 64406330 | 64406459 | Frame-shift |
| ENST00000261884 | 64414085 | 64414211 | Frame-shift |
| ENST00000261884 | 64425540 | 64425631 | Frame-shift |
| ENST00000261884 | 64445006 | 64445108 | Frame-shift |
| ENST00000261884 | 64397606 | 64397818 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261884 | 64395398 | 64395531 | Frame-shift |
| ENST00000261884 | 64406330 | 64406459 | Frame-shift |
| ENST00000261884 | 64414085 | 64414211 | Frame-shift |
| ENST00000261884 | 64445006 | 64445108 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261884 | 64395398 | 64395531 | Frame-shift |
| ENST00000261884 | 64406330 | 64406459 | Frame-shift |
| ENST00000261884 | 64414085 | 64414211 | Frame-shift |
| ENST00000261884 | 64425540 | 64425631 | Frame-shift |
| ENST00000261884 | 64445006 | 64445108 | Frame-shift |
| ENST00000261884 | 64397606 | 64397818 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIP4 |
p-ENSG00000103671_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261884 | 2062 | 581 | 64397606 | 64397818 | 467 | 678 | 135 | 206 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261884 | 2062 | 581 | 64397606 | 64397818 | 467 | 678 | 135 | 206 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15650 | 135 | 206 | 2 | 581 | Chain | ID=PRO_0000065631;Note=Activating signal cointegrator 1 |
| Q15650 | 135 | 206 | 200 | 300 | Region | Note=Mediates interaction with DDRGK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498 |
| Q15650 | 135 | 206 | 157 | 157 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15650 | 135 | 206 | 157 | 157 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15650 | 135 | 206 | 164 | 164 | Sequence conflict | Note=L->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15650 | 135 | 206 | 171 | 187 | Zinc finger | Note=C4-type |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15650 | 135 | 206 | 2 | 581 | Chain | ID=PRO_0000065631;Note=Activating signal cointegrator 1 |
| Q15650 | 135 | 206 | 200 | 300 | Region | Note=Mediates interaction with DDRGK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25219498;Dbxref=PMID:25219498 |
| Q15650 | 135 | 206 | 157 | 157 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15650 | 135 | 206 | 157 | 157 | Sequence conflict | Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15650 | 135 | 206 | 164 | 164 | Sequence conflict | Note=L->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15650 | 135 | 206 | 171 | 187 | Zinc finger | Note=C4-type |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIP4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIP4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIP4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIP4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIP4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_211417 | 4.714059e-01 | 3.572044e-10 |
| CB | RBM45 | exon_skip_132793 | 4.478126e-01 | 2.048380e-08 |
| CB | RBM6 | exon_skip_239922 | -5.596748e-01 | 1.733662e-14 |
| CB | RBM3 | exon_skip_239922 | 5.014398e-01 | 1.667228e-11 |
| CB | TRA2A | exon_skip_239922 | -4.201635e-01 | 3.515575e-08 |
| CB | RBM45 | exon_skip_239922 | 6.069205e-01 | 2.253574e-17 |
| CB | NUP42 | exon_skip_239922 | 4.680358e-01 | 4.947283e-10 |
| TC | RBM3 | exon_skip_90089 | 4.028085e-01 | 1.287160e-07 |
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RelatedDrugs for TRIP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIP4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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