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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIP11 |
 Gene summary |
| Gene information | Gene symbol | TRIP11 | Gene ID | 9321 |
| Gene name | thyroid hormone receptor interactor 11 | |
| Synonyms | ACG1A|CEV14|GMAP-210|GMAP210|ODCD|TRIP-11|TRIP230 | |
| Cytomap | 14q32.12 | |
| Type of gene | protein-coding | |
| Description | thyroid receptor-interacting protein 11Golgi-microtubule-associated protein of 210 kDaTR-interacting protein 11clonal evolution-related gene on chromosome 14 proteingolgi-associated microtubule-binding protein 210 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TRIP11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100815
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000554357.5 | TRIP11-202:protein_coding:TRIP11 | 3.196588e+01 | 1.516015e+00 | 7.711166e-05 | 5.952030e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIP11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_182660 | chr14 | 91993809:91993912:91995352:91995515:91999240:91999379 | 91995352:91995515 |
| exon_skip_20689 | chr14 | 92010986:92011072:92011755:92011795:92014215:92014577 | 92011755:92011795 |
| exon_skip_207277 | chr14 | 92007640:92007852:92011755:92011795:92014215:92014577 | 92011755:92011795 |
| exon_skip_235334 | chr14 | 91999968:92000108:92003419:92006448:92007640:92007852 | 92003419:92006448 |
| exon_skip_265557 | chr14 | 91975172:91975286:91976108:91976189:91988284:91988383 | 91976108:91976189 |
| exon_skip_271546 | chr14 | 92017682:92017750:92021556:92021831:92025310:92025420 | 92021556:92021831 |
| exon_skip_50444 | chr14 | 92007640:92007852:92010986:92011072:92011755:92011795 | 92010986:92011072 |
| exon_skip_69746 | chr14 | 91976108:91976189:91977126:91977248:91988284:91988383 | 91977126:91977248 |
| exon_skip_84014 | chr14 | 91972717:91972861:91974627:91974743:91975172:91975286 | 91974627:91974743 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIP11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000267622 | 91976108 | 91976189 | Frame-shift |
| ENST00000267622 | 91995352 | 91995515 | Frame-shift |
| ENST00000267622 | 92010986 | 92011072 | In-frame |
| ENST00000267622 | 92021556 | 92021831 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000267622 | 91976108 | 91976189 | Frame-shift |
| ENST00000267622 | 92011755 | 92011795 | Frame-shift |
| ENST00000267622 | 92010986 | 92011072 | In-frame |
| ENST00000267622 | 92021556 | 92021831 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000267622 | 91976108 | 91976189 | Frame-shift |
| ENST00000267622 | 91995352 | 91995515 | Frame-shift |
| ENST00000267622 | 92011755 | 92011795 | Frame-shift |
| ENST00000267622 | 91974627 | 91974743 | In-frame |
| ENST00000267622 | 92003419 | 92006448 | In-frame |
| ENST00000267622 | 92010986 | 92011072 | In-frame |
| ENST00000267622 | 92021556 | 92021831 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIP11 |
p-ENSG00000100815_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000267622 | 10013 | 1979 | 92021556 | 92021831 | 687 | 961 | 104 | 195 |
| ENST00000267622 | 10013 | 1979 | 92010986 | 92011072 | 1602 | 1687 | 409 | 437 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000267622 | 10013 | 1979 | 92021556 | 92021831 | 687 | 961 | 104 | 195 |
| ENST00000267622 | 10013 | 1979 | 92010986 | 92011072 | 1602 | 1687 | 409 | 437 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000267622 | 10013 | 1979 | 92021556 | 92021831 | 687 | 961 | 104 | 195 |
| ENST00000267622 | 10013 | 1979 | 92010986 | 92011072 | 1602 | 1687 | 409 | 437 |
| ENST00000267622 | 10013 | 1979 | 92003419 | 92006448 | 1902 | 4930 | 509 | 1518 |
| ENST00000267622 | 10013 | 1979 | 91974627 | 91974743 | 5832 | 5947 | 1819 | 1857 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15643 | 104 | 195 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 104 | 195 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q15643 | 104 | 195 | 121 | 121 | Sequence conflict | Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 409 | 437 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 409 | 437 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15643 | 104 | 195 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 104 | 195 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q15643 | 104 | 195 | 121 | 121 | Sequence conflict | Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 409 | 437 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 409 | 437 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15643 | 104 | 195 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 104 | 195 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q15643 | 104 | 195 | 121 | 121 | Sequence conflict | Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 409 | 437 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 409 | 437 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q15643 | 509 | 1518 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 509 | 1518 | 52 | 1773 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q15643 | 509 | 1518 | 559 | 559 | Natural variant | ID=VAR_079175;Note=V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27717682;Dbxref=PMID:27717682 |
| Q15643 | 509 | 1518 | 795 | 795 | Natural variant | ID=VAR_055863;Note=V->L;Dbxref=dbSNP:rs34699762 |
| Q15643 | 509 | 1518 | 884 | 884 | Natural variant | ID=VAR_055864;Note=D->G;Dbxref=dbSNP:rs34967261 |
| Q15643 | 509 | 1518 | 1040 | 1040 | Natural variant | ID=VAR_055865;Note=I->V;Dbxref=dbSNP:rs34805848 |
| Q15643 | 509 | 1518 | 1107 | 1107 | Natural variant | ID=VAR_060344;Note=E->D;Dbxref=dbSNP:rs4619320 |
| Q15643 | 509 | 1518 | 1413 | 1413 | Natural variant | ID=VAR_060345;Note=D->A;Dbxref=dbSNP:rs12884523 |
| Q15643 | 509 | 1518 | 1503 | 1503 | Natural variant | ID=VAR_055866;Note=M->V;Dbxref=dbSNP:rs34839498 |
| Q15643 | 509 | 1518 | 516 | 516 | Sequence conflict | Note=D->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 509 | 1518 | 561 | 563 | Sequence conflict | Note=KEK->FVL;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 509 | 1518 | 1202 | 1202 | Sequence conflict | Note=N->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 509 | 1518 | 1237 | 1237 | Sequence conflict | Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 509 | 1518 | 1346 | 1347 | Sequence conflict | Note=QQ->HE;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15643 | 1819 | 1857 | 2 | 1979 | Chain | ID=PRO_0000190076;Note=Thyroid receptor-interacting protein 11 |
| Q15643 | 1819 | 1857 | 1774 | 1823 | Domain | Note=GRIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00250 |
| Q15643 | 1819 | 1857 | 1842 | 1842 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231 |
| Q15643 | 1819 | 1857 | 1846 | 1846 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332;Dbxref=PMID:18669648,PMID:19690332 |
| Q15643 | 1819 | 1857 | 1827 | 1827 | Natural variant | ID=VAR_060346;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10189370,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7776974,ECO:0000269|PubMed:9373237;Dbxref=dbSNP:rs1051340,PMID:10189370,PMID:15489334 |
| Q15643 | 1819 | 1857 | 1846 | 1846 | Natural variant | ID=VAR_054151;Note=T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18987736;Dbxref=dbSNP:rs141259390,PMID:18987736 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIP11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIP11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIP11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIP11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIP11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_265557 | -5.495266e-01 | 3.280007e-13 |
| CB | RBM3 | exon_skip_265557 | 4.295969e-01 | 4.114378e-08 |
| CB | NUP42 | exon_skip_265557 | 5.011860e-01 | 6.478049e-11 |
| TC | RBM3 | exon_skip_265557 | 4.392463e-01 | 1.679579e-08 |
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RelatedDrugs for TRIP11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIP11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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