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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAGI1 |
 Gene summary |
| Gene information | Gene symbol | MAGI1 | Gene ID | 9223 |
| Gene name | membrane associated guanylate kinase, WW and PDZ domain containing 1 | |
| Synonyms | AIP-3|AIP3|BAIAP1|BAP-1|BAP1|MAGI-1|MAGI-1b|Magi1d|TNRC19|WWP3 | |
| Cytomap | 3p14.1 | |
| Type of gene | protein-coding | |
| Description | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1BAI1-associated protein 1WW domain-containing protein 3atrophin-1-interacting protein 3membrane-associated guanylate kinase inverted 1trinucleotide repeat-containing gene 19 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAGI1 | GO:0022409 | positive regulation of cell-cell adhesion | 20298433 |
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Gene structures and expression levels for MAGI1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000151276
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000621418.4 | MAGI1-218:protein_coding:MAGI1 | 1.501767e+02 | 1.619080e+00 | 1.627911e-11 | 1.449857e-09 |
| CB | UP | ENST00000483466.5 | MAGI1-213:protein_coding:MAGI1 | 1.435524e+02 | 8.160124e-01 | 3.173894e-04 | 1.964475e-03 |
| TC | DOWN | ENST00000468159.1 | MAGI1-206:retained_intron:MAGI1 | 4.684734e+00 | -8.885793e-01 | 2.801480e-04 | 3.652705e-03 |
| TC | UP | ENST00000479287.1 | MAGI1-211:protein_coding:MAGI1 | 1.212643e+00 | 1.129818e+00 | 4.248954e-04 | 5.060339e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAGI1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_12741 | chr3 | 65356378:65357132:65359064:65359152:65361199:65361337 | 65359064:65359152 |
| exon_skip_139977 | chr3 | 65442792:65442849:65448022:65448057:65453258:65453340 | 65448022:65448057 |
| exon_skip_16089 | chr3 | 65387143:65387226:65391142:65391358:65401439:65401470 | 65391142:65391358 |
| exon_skip_164746 | chr3 | 65391142:65391358:65401439:65401470:65429520:65430140 | 65401439:65401470 |
| exon_skip_192224 | chr3 | 65391142:65391358:65401439:65401470:65429520:65429665 | 65401439:65401470 |
| exon_skip_192479 | chr3 | 65364853:65364946:65375745:65375948:65379261:65379554 | 65375745:65375948 |
| exon_skip_22306 | chr3 | 65448022:65448057:65453258:65453340:65470283:65470484 | 65453258:65453340 |
| exon_skip_228835 | chr3 | 65364853:65364946:65375745:65375945:65379261:65379554 | 65375745:65375945 |
| exon_skip_260776 | chr3 | 65493512:65493631:65609744:65609966:65621972:65622088 | 65609744:65609966 |
| exon_skip_76049 | chr3 | 65383532:65383623:65387143:65387226:65391142:65391358 | 65387143:65387226 |
| exon_skip_78443 | chr3 | 65439879:65440012:65442792:65442849:65453258:65453340 | 65442792:65442849 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_12741 | Mayo_CB | 5.301220e-01 | 7.304478e-01 | -2.003258e-01 | 4.262950e-09 |
| exon_skip_12741 | Mayo_TC | 6.113750e-01 | 7.498413e-01 | -1.384663e-01 | 2.426568e-06 |
| exon_skip_76049 | Mayo_TC | 4.396341e-01 | 5.455882e-01 | -1.059541e-01 | 3.466118e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for MAGI1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MAGI1 |
p-ENSG00000151276_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAGI1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAGI1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAGI1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAGI1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAGI1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_12741 | -5.148883e-01 | 1.842619e-11 |
| CB | RBM6 | exon_skip_12741 | -5.486389e-01 | 4.371088e-13 |
| CB | FUBP1 | exon_skip_12741 | -5.294731e-01 | 3.848522e-12 |
| CB | HNRNPA2B1 | exon_skip_12741 | -5.104470e-01 | 2.925573e-11 |
| CB | RBM45 | exon_skip_12741 | 7.127993e-01 | 2.069455e-24 |
| CB | NUP42 | exon_skip_12741 | 5.981660e-01 | 7.930079e-16 |
| CB | HNRNPF | exon_skip_12741 | -4.053936e-01 | 2.917074e-07 |
| CB | RBM4B | exon_skip_12741 | -4.653703e-01 | 2.232545e-09 |
| CB | NUP42 | exon_skip_76049 | 4.993532e-01 | 1.209709e-10 |
| HCC | RBFOX2 | exon_skip_12741 | 4.380611e-01 | 4.740010e-13 |
| HCC | HNRNPF | exon_skip_12741 | -4.476824e-01 | 1.260023e-13 |
| HCC | ZNF326 | exon_skip_76049 | -5.064022e-01 | 3.121055e-17 |
| HCC | RBM47 | exon_skip_76049 | -4.749190e-01 | 4.485006e-15 |
| HCC | HNRNPF | exon_skip_76049 | -5.276373e-01 | 8.096127e-19 |
| HCC | RBM4B | exon_skip_76049 | -4.173759e-01 | 1.161744e-11 |
| IFG | TARDBP | exon_skip_12741 | -4.563840e-01 | 2.183903e-02 |
| IFG | RBM47 | exon_skip_12741 | -4.573136e-01 | 2.153779e-02 |
| IFG | HNRNPF | exon_skip_12741 | -4.274989e-01 | 3.304026e-02 |
| PCC | RBFOX2 | exon_skip_12741 | 4.876927e-01 | 2.523559e-12 |
| PCC | RBM6 | exon_skip_12741 | -4.051578e-01 | 1.276468e-08 |
| PCC | RBM47 | exon_skip_12741 | -5.272164e-01 | 1.755888e-14 |
| PCC | HNRNPF | exon_skip_12741 | -4.276326e-01 | 1.562312e-09 |
| PCC | ELAVL4 | exon_skip_228835 | 4.045762e-01 | 4.882920e-08 |
| PCC | RBM47 | exon_skip_228835 | -4.142314e-01 | 2.160943e-08 |
| PCC | RBM47 | exon_skip_192479 | -4.274483e-01 | 2.169799e-09 |
| PCC | RBM47 | exon_skip_76049 | -4.988604e-01 | 2.757985e-13 |
| PCC | HNRNPF | exon_skip_76049 | -4.211676e-01 | 1.591962e-09 |
| TC | RBFOX2 | exon_skip_12741 | 6.102739e-01 | 5.902530e-16 |
| TC | ILF2 | exon_skip_12741 | 4.947685e-01 | 3.363403e-10 |
| TC | HNRNPDL | exon_skip_12741 | 4.778865e-01 | 1.583561e-09 |
| TC | RBM45 | exon_skip_12741 | 4.969555e-01 | 2.734661e-10 |
| TC | NUP42 | exon_skip_12741 | 5.929408e-01 | 6.082063e-15 |
| TC | EWSR1 | exon_skip_12741 | 4.219900e-01 | 1.527075e-07 |
| TC | HNRNPH2 | exon_skip_12741 | 6.297588e-01 | 3.595414e-17 |
| TC | ESRP1 | exon_skip_12741 | 4.890842e-01 | 5.720491e-10 |
| TC | NOVA1 | exon_skip_12741 | 7.222131e-01 | 2.460106e-24 |
| TC | NUP42 | exon_skip_76049 | 6.983722e-01 | 2.966992e-23 |
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RelatedDrugs for MAGI1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAGI1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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