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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZMYM5 |
Gene summary |
Gene information | Gene symbol | ZMYM5 | Gene ID | 9205 |
Gene name | zinc finger MYM-type containing 5 | |
Synonyms | HSPC050|MYM|ZNF198L1|ZNF237 | |
Cytomap | 13q12.11 | |
Type of gene | protein-coding | |
Description | zinc finger MYM-type protein 5zinc finger protein 198-like 1zinc finger protein 237zinc finger, MYM-type 5 | |
Modification date | 20200320 | |
UniProtAcc | A0A024RDQ2, Q9UJ78, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZMYM5 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000382909.5 | ZMYM5-204:retained_intron:ZMYM5 | 9.989175e+01 | -8.303416e-01 | 1.255203e-03 | 6.250649e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZMYM5 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_130283 | chr13 | 19837751:19837821:19838700:19838985:19851355:19851448 | 19838700:19838985 |
exon_skip_144174 | chr13 | 19835477:19835689:19837656:19837821:19838700:19838985 | 19837656:19837821 |
exon_skip_168982 | chr13 | 19851689:19852190:19862399:19862466:19863450:19863508 | 19862399:19862466 |
exon_skip_208749 | chr13 | 19837656:19837821:19838700:19838985:19851355:19851448 | 19838700:19838985 |
exon_skip_232522 | chr13 | 19838902:19838985:19851355:19851448:19851689:19852190 | 19851355:19851448 |
exon_skip_242241 | chr13 | 19838700:19838985:19851355:19851448:19851689:19852190 | 19851355:19851448 |
exon_skip_268382 | chr13 | 19835477:19835689:19837656:19837821:19851355:19851448 | 19837656:19837821 |
exon_skip_3300 | chr13 | 19851694:19852190:19862399:19862466:19863450:19863508 | 19862399:19862466 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZMYM5 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000382905 | 19862399 | 19862466 | 3UTR-3UTR |
ENST00000382905 | 19838700 | 19838985 | Frame-shift |
ENST00000382905 | 19851355 | 19851448 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000382905 | 19862399 | 19862466 | 3UTR-3UTR |
ENST00000382905 | 19838700 | 19838985 | Frame-shift |
ENST00000382905 | 19851355 | 19851448 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000382905 | 19862399 | 19862466 | 3UTR-3UTR |
ENST00000382905 | 19838700 | 19838985 | Frame-shift |
ENST00000382905 | 19851355 | 19851448 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZMYM5 |
p-ENSG00000132950_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZMYM5 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000382905 | 19862399 | 19862466 | hsa-miR-3188 | chr13:19862430-19862437 | 8mer-1a | chr13:19862416-19862437 | 164.00 | -22.75 |
MSBB | ENST00000382905 | 19862399 | 19862466 | hsa-miR-3188 | chr13:19862430-19862437 | 8mer-1a | chr13:19862416-19862437 | 164.00 | -22.75 |
ROSMAP | ENST00000382905 | 19862399 | 19862466 | hsa-miR-3188 | chr13:19862430-19862437 | 8mer-1a | chr13:19862416-19862437 | 164.00 | -22.75 |
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SNVs in the skipped exons for ZMYM5 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZMYM5 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZMYM5 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZMYM5 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | DAZAP1 | exon_skip_144174 | -4.009613e-01 | 2.491328e-06 |
CB | PABPN1 | exon_skip_144174 | -4.474113e-01 | 1.061791e-07 |
CB | PCBP4 | exon_skip_144174 | 5.258945e-01 | 1.555060e-10 |
CB | TRA2A | exon_skip_144174 | -6.032917e-01 | 3.838673e-14 |
CB | FUBP1 | exon_skip_144174 | -4.920666e-01 | 3.172992e-09 |
CB | HNRNPDL | exon_skip_144174 | 4.092260e-01 | 1.470148e-06 |
CB | NUP42 | exon_skip_144174 | 5.179590e-01 | 3.250766e-10 |
CB | DAZAP1 | exon_skip_268382 | -4.187700e-01 | 2.365963e-06 |
CB | HNRNPDL | exon_skip_14027 | 4.641527e-01 | 1.426384e-08 |
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RelatedDrugs for ZMYM5 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZMYM5 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |