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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DCLK1 |
 Gene summary |
| Gene information | Gene symbol | DCLK1 | Gene ID | 9201 |
| Gene name | doublecortin like kinase 1 | |
| Synonyms | CL1|CLICK1|DCAMKL1|DCDC3A|DCLK | |
| Cytomap | 13q13.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1 | |
| Modification date | 20200320 | |
| UniProtAcc | O15075, Q5VZY9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DCLK1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000133083
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| FL | DOWN | ENST00000615680.4 | DCLK1-208:protein_coding:DCLK1 | 2.823995e+02 | -8.960556e-01 | 7.932632e-06 | 5.175715e-03 |
| PG | DOWN | ENST00000615680.4 | DCLK1-208:protein_coding:DCLK1 | 1.036295e+02 | -1.186467e+00 | 7.395540e-06 | 4.022473e-04 |
| PG | DOWN | ENST00000379893.5 | DCLK1-204:protein_coding:DCLK1 | 6.984684e+02 | -8.080635e-01 | 3.097999e-03 | 3.255461e-02 |
| CB | DOWN | ENST00000615680.4 | DCLK1-208:protein_coding:DCLK1 | 2.327051e+02 | -1.376827e+00 | 1.034742e-08 | 3.093778e-07 |
| CB | UP | ENST00000379892.4 | DCLK1-203:protein_coding:DCLK1 | 7.235117e+00 | 8.785900e-01 | 8.070517e-03 | 2.916435e-02 |
| TC | UP | ENST00000379892.4 | DCLK1-203:protein_coding:DCLK1 | 7.763867e+00 | 1.198522e+00 | 6.029371e-05 | 1.081184e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DCLK1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10626 | chr13 | 35827635:35827754:35828250:35828307:35836033:35836141 | 35828250:35828307 |
| exon_skip_14366 | chr13 | 35871224:35871340:35947358:35947457:36111869:36112071 | 35947358:35947457 |
| exon_skip_157000 | chr13 | 35808224:35808320:35809018:35809095:35810835:35810968 | 35809018:35809095 |
| exon_skip_166824 | chr13 | 35810835:35810968:35822729:35822875:35827635:35827754 | 35822729:35822875 |
| exon_skip_238868 | chr13 | 35774485:35774699:35788212:35788285:35793366:35793479 | 35788212:35788285 |
| exon_skip_52899 | chr13 | 35805699:35805779:35808224:35808320:35809018:35809095 | 35808224:35808320 |
| exon_skip_54011 | chr13 | 35854499:35854593:35871224:35871340:35947358:35947457 | 35871224:35871340 |
| exon_skip_54164 | chr13 | 35871224:35871340:35947358:35947457:36111869:36112215 | 35947358:35947457 |
| exon_skip_73198 | chr13 | 35771341:35774699:35788212:35788285:35793366:35793479 | 35788212:35788285 |
| exon_skip_82016 | chr13 | 35839092:35839176:35854499:35854593:35871224:35871340 | 35854499:35854593 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DCLK1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360631 | 35808224 | 35808320 | Frame-shift |
| ENST00000360631 | 35854499 | 35854593 | Frame-shift |
| ENST00000360631 | 35947358 | 35947457 | Frame-shift |
| ENST00000360631 | 35809018 | 35809095 | In-frame |
| ENST00000360631 | 35822729 | 35822875 | In-frame |
| ENST00000360631 | 35871224 | 35871340 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360631 | 35947358 | 35947457 | Frame-shift |
| ENST00000360631 | 35809018 | 35809095 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360631 | 35828250 | 35828307 | Frame-shift |
| ENST00000360631 | 35854499 | 35854593 | Frame-shift |
| ENST00000360631 | 35809018 | 35809095 | In-frame |
| ENST00000360631 | 35822729 | 35822875 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DCLK1 |
p-ENSG00000133083_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360631 | 8024 | 740 | 35871224 | 35871340 | 1036 | 1151 | 274 | 313 |
| ENST00000360631 | 8024 | 740 | 35822729 | 35822875 | 1620 | 1765 | 469 | 517 |
| ENST00000360631 | 8024 | 740 | 35809018 | 35809095 | 1901 | 1977 | 563 | 588 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360631 | 8024 | 740 | 35809018 | 35809095 | 1901 | 1977 | 563 | 588 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000360631 | 8024 | 740 | 35822729 | 35822875 | 1620 | 1765 | 469 | 517 |
| ENST00000360631 | 8024 | 740 | 35809018 | 35809095 | 1901 | 1977 | 563 | 588 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15075 | 274 | 313 | 1 | 307 | Alternative sequence | ID=VSP_004905;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9747029;Dbxref=PMID:14702039,PMID:9747029 |
| O15075 | 274 | 313 | 308 | 313 | Alternative sequence | ID=VSP_004906;Note=In isoform 3 and isoform 4. PASTSS->MLELIE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:9747029;Dbxref=PMID:14702039,PMID:9747029 |
| O15075 | 274 | 313 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 274 | 313 | 288 | 340 | Compositional bias | Note=Pro/Ser-rich |
| O15075 | 274 | 313 | 305 | 305 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLM8 |
| O15075 | 274 | 313 | 307 | 307 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JLM8 |
| O15075 | 274 | 313 | 291 | 291 | Natural variant | ID=VAR_045676;Note=In a gastric adenocarcinoma sample%3B somatic mutation. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| O15075 | 274 | 313 | 292 | 292 | Natural variant | ID=VAR_045677;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56185003,PMID:17344846 |
| O15075 | 469 | 517 | 511 | 511 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| O15075 | 469 | 517 | 517 | 521 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 469 | 517 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 469 | 517 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 469 | 517 | 473 | 480 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 469 | 517 | 485 | 504 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 469 | 517 | 514 | 516 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 563 | 588 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 563 | 588 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 563 | 588 | 568 | 582 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15075 | 563 | 588 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 563 | 588 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 563 | 588 | 568 | 582 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15075 | 469 | 517 | 511 | 511 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| O15075 | 469 | 517 | 517 | 521 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 469 | 517 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 469 | 517 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 469 | 517 | 473 | 480 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 469 | 517 | 485 | 504 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 469 | 517 | 514 | 516 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
| O15075 | 563 | 588 | 1 | 740 | Chain | ID=PRO_0000085919;Note=Serine/threonine-protein kinase DCLK1 |
| O15075 | 563 | 588 | 390 | 647 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O15075 | 563 | 588 | 568 | 582 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5JZJ |
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3'-UTR located exon skipping events that lost miRNA binding sites in DCLK1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DCLK1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DCLK1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCLK1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DCLK1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SRSF2 | exon_skip_73198 | 4.212689e-01 | 7.949145e-08 |
| CB | RALYL | exon_skip_73198 | 4.828201e-01 | 3.919746e-10 |
| CB | SRSF9 | exon_skip_73198 | 5.183842e-01 | 1.086343e-11 |
| PG | RALYL | exon_skip_73198 | 5.249459e-01 | 1.436886e-12 |
| PG | NOVA1 | exon_skip_73198 | 4.181289e-01 | 4.587242e-08 |
| TC | RALYL | exon_skip_73198 | 5.599350e-01 | 3.601627e-14 |
| TC | NOVA1 | exon_skip_73198 | 4.016544e-01 | 2.220132e-07 |
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RelatedDrugs for DCLK1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O15075 | approved|investigational | DB12010 | Fostamatinib | small molecule | O15075 |
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RelatedDiseases for DCLK1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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