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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for LPAR2 |
Gene summary |
Gene information | Gene symbol | LPAR2 | Gene ID | 9170 |
Gene name | lysophosphatidic acid receptor 2 | |
Synonyms | EDG-4|EDG4|LPA-2|LPA2 | |
Cytomap | 19p13.11 | |
Type of gene | protein-coding | |
Description | lysophosphatidic acid receptor 2G protein-coupled receptorLPA receptor 2LPA receptor EDG4endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4lysophosphatidic acid receptor EDG4lysophosphatidic acid receptor Edg-4 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for LPAR2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LPAR2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_277057 | chr19 | 19627397:19627504:19627754:19627969:19628092:19628167 | 19627754:19627969 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LPAR2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000542587 | 19627754 | 19627969 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000542587 | 19627754 | 19627969 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for LPAR2 |
p-ENSG00000064547_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in LPAR2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-139-3p | chr19:19627960-19627967 | 8mer-1a | chr19:19627940-19627967 | 150.00 | -28.18 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-6793-3p | chr19:19627927-19627934 | 8mer-1a | chr19:19627923-19627945 | 165.00 | -23.02 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-128-1-5p | chr19:19627812-19627819 | 8mer-1a | chr19:19627797-19627819 | 164.00 | -28.42 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-1292-3p | chr19:19627840-19627847 | 8mer-1a | chr19:19627829-19627847 | 156.00 | -30.65 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-1306-5p | chr19:19627786-19627793 | 8mer-1a | chr19:19627768-19627793 | 146.00 | -27.04 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-128-2-5p | chr19:19627812-19627819 | 8mer-1a | chr19:19627797-19627819 | 164.00 | -28.42 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-4449 | chr19:19627910-19627917 | 8mer-1a | chr19:19627897-19627917 | 157.00 | -29.54 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-4646-3p | chr19:19627912-19627919 | 8mer-1a | chr19:19627903-19627926 | 155.00 | -17.61 |
Mayo | ENST00000542587 | 19627754 | 19627969 | hsa-miR-10398-3p | chr19:19627908-19627915 | 8mer-1a | chr19:19627897-19627917 | 157.00 | -29.54 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-139-3p | chr19:19627960-19627967 | 8mer-1a | chr19:19627940-19627967 | 150.00 | -28.18 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-6793-3p | chr19:19627927-19627934 | 8mer-1a | chr19:19627923-19627945 | 165.00 | -23.02 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-128-1-5p | chr19:19627812-19627819 | 8mer-1a | chr19:19627797-19627819 | 164.00 | -28.42 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-1292-3p | chr19:19627840-19627847 | 8mer-1a | chr19:19627829-19627847 | 156.00 | -30.65 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-1306-5p | chr19:19627786-19627793 | 8mer-1a | chr19:19627768-19627793 | 146.00 | -27.04 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-128-2-5p | chr19:19627812-19627819 | 8mer-1a | chr19:19627797-19627819 | 164.00 | -28.42 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-4449 | chr19:19627910-19627917 | 8mer-1a | chr19:19627897-19627917 | 157.00 | -29.54 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-4646-3p | chr19:19627912-19627919 | 8mer-1a | chr19:19627903-19627926 | 155.00 | -17.61 |
ROSMAP | ENST00000542587 | 19627754 | 19627969 | hsa-miR-10398-3p | chr19:19627908-19627915 | 8mer-1a | chr19:19627897-19627917 | 157.00 | -29.54 |
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SNVs in the skipped exons for LPAR2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LPAR2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LPAR2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LPAR2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for LPAR2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPAR2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |