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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FIBP |
Gene summary |
Gene information | Gene symbol | FIBP | Gene ID | 9158 |
Gene name | FGF1 intracellular binding protein | |
Synonyms | FGFIBP|FIBP-1|TROFAS | |
Cytomap | 11q13.1 | |
Type of gene | protein-coding | |
Description | acidic fibroblast growth factor intracellular-binding proteinaFGF intracellular-binding protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FIBP |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000338369.6 | FIBP-201:protein_coding:FIBP | 7.481174e+01 | -8.250053e-01 | 3.303191e-12 | 4.015893e-10 |
CB | DOWN | ENST00000531115.5 | FIBP-207:nonsense_mediated_decay:FIBP | 5.564778e+00 | -1.264014e+00 | 1.477766e-06 | 2.089645e-05 |
TC | DOWN | ENST00000531115.5 | FIBP-207:nonsense_mediated_decay:FIBP | 6.203178e+00 | -1.098780e+00 | 3.275993e-06 | 1.063063e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FIBP |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_104326 | chr11 | 65885530:65885663:65886322:65886422:65887600:65887726 | 65886322:65886422 |
exon_skip_104758 | chr11 | 65885534:65885663:65886322:65886422:65887600:65887726 | 65886322:65886422 |
exon_skip_125952 | chr11 | 65885583:65885663:65886322:65886422:65887600:65887726 | 65886322:65886422 |
exon_skip_240428 | chr11 | 65887600:65887726:65887934:65888132:65888334:65888436 | 65887934:65888132 |
exon_skip_290455 | chr11 | 65885331:65885821:65886322:65886422:65887600:65887726 | 65886322:65886422 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FIBP |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000338369 | 65886322 | 65886422 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000338369 | 65886322 | 65886422 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000338369 | 65886322 | 65886422 | Frame-shift |
ENST00000338369 | 65887934 | 65888132 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for FIBP |
p-ENSG00000172500_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FIBP |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FIBP |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FIBP |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FIBP |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FIBP |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
DLPFC | SFPQ | exon_skip_104758 | 4.233774e-01 | 4.950801e-12 |
DLPFC | ILF2 | exon_skip_104758 | 4.556769e-01 | 6.514929e-14 |
DLPFC | KHDRBS3 | exon_skip_104758 | 4.262944e-01 | 3.411041e-12 |
DLPFC | HNRNPDL | exon_skip_104758 | 4.264687e-01 | 3.335569e-12 |
DLPFC | RBM23 | exon_skip_104758 | 4.056033e-01 | 4.441279e-11 |
DLPFC | EWSR1 | exon_skip_104758 | 5.104941e-01 | 1.351431e-17 |
DLPFC | SRSF9 | exon_skip_104758 | 4.181124e-01 | 9.611211e-12 |
DLPFC | ESRP1 | exon_skip_104758 | 4.152724e-01 | 1.368114e-11 |
TC | ILF2 | exon_skip_104758 | 4.560167e-01 | 1.363186e-09 |
TC | KHDRBS3 | exon_skip_104758 | 4.646087e-01 | 6.060589e-10 |
TC | HNRNPDL | exon_skip_104758 | 4.681329e-01 | 4.317944e-10 |
TC | EWSR1 | exon_skip_104758 | 4.060290e-01 | 9.989774e-08 |
TC | ESRP1 | exon_skip_104758 | 4.446869e-01 | 3.837913e-09 |
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RelatedDrugs for FIBP |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FIBP |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |