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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for MTA1 |
Gene summary |
Gene information | Gene symbol | MTA1 | Gene ID | 9112 |
Gene name | metastasis associated 1 | |
Synonyms | - | |
Cytomap | 14q32.33 | |
Type of gene | protein-coding | |
Description | metastasis-associated protein MTA1metastasis associated gene 1 protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
MTA1 | GO:0010212 | response to ionizing radiation | 19805145 |
MTA1 | GO:1902499 | positive regulation of protein autoubiquitination | 19805145 |
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Gene structures and expression levels for MTA1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000495233.5 | CAMTA1-215:protein_coding:CAMTA1 | 8.525019e+02 | 8.300552e-01 | 5.058148e-04 | 2.909183e-03 |
CB | UP | ENST00000467267.1 | CAMTA1-204:lncRNA:CAMTA1 | 1.080271e+00 | 8.387535e-01 | 2.585059e-03 | 1.140114e-02 |
TC | UP | ENST00000467267.1 | CAMTA1-204:lncRNA:CAMTA1 | 9.784188e-01 | 8.277022e-01 | 7.592771e-03 | 4.570215e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MTA1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_117591 | chr14 | 105466426:105466578:105466707:105466742:105469467:105469498 | 105466707:105466742 |
exon_skip_184152 | chr14 | 105460894:105460953:105463184:105463258:105463493:105463551 | 105463184:105463258 |
exon_skip_204342 | chr14 | 105450261:105450324:105454193:105454310:105458270:105458371 | 105454193:105454310 |
exon_skip_22414 | chr14 | 105466707:105466742:105468338:105468349:105469467:105469498 | 105468338:105468349 |
exon_skip_284499 | chr14 | 105454193:105454310:105454628:105454701:105458270:105458371 | 105454628:105454701 |
exon_skip_293021 | chr14 | 105445418:105445511:105449359:105449409:105450058:105450184 | 105449359:105449409 |
exon_skip_86369 | chr14 | 105464674:105464863:105465094:105465183:105466426:105466578 | 105465094:105465183 |
exon_skip_94950 | chr14 | 105438672:105438739:105445418:105445511:105449359:105449409 | 105445418:105445511 |
exon_skip_9530 | chr14 | 105445418:105445511:105445667:105445852:105449359:105449409 | 105445667:105445852 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_145482 | Mayo_CB | 7.037805e-01 | 8.117105e-01 | -1.079300e-01 | 1.796037e-06 |
exon_skip_145482 | Mayo_TC | 4.468493e-01 | 5.888333e-01 | -1.419840e-01 | 1.004398e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for MTA1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000331320 | 105445418 | 105445511 | Frame-shift |
ENST00000331320 | 105449359 | 105449409 | In-frame |
ENST00000331320 | 105465094 | 105465183 | In-frame |
ENST00000331320 | 105466707 | 105466742 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000331320 | 105449359 | 105449409 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000331320 | 105445418 | 105445511 | Frame-shift |
ENST00000331320 | 105454193 | 105454310 | Frame-shift |
ENST00000331320 | 105449359 | 105449409 | In-frame |
ENST00000331320 | 105463184 | 105463258 | In-frame |
ENST00000331320 | 105465094 | 105465183 | In-frame |
ENST00000331320 | 105466707 | 105466742 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MTA1 |
p-ENSG00000182979_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000331320 | 2893 | 715 | 105449359 | 105449409 | 406 | 455 | 64 | 80 |
ENST00000331320 | 2893 | 715 | 105465094 | 105465183 | 1750 | 1838 | 512 | 541 |
ENST00000331320 | 2893 | 715 | 105466707 | 105466742 | 1993 | 2027 | 593 | 604 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000331320 | 2893 | 715 | 105449359 | 105449409 | 406 | 455 | 64 | 80 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000331320 | 2893 | 715 | 105449359 | 105449409 | 406 | 455 | 64 | 80 |
ENST00000331320 | 2893 | 715 | 105463184 | 105463258 | 1158 | 1231 | 314 | 339 |
ENST00000331320 | 2893 | 715 | 105465094 | 105465183 | 1750 | 1838 | 512 | 541 |
ENST00000331320 | 2893 | 715 | 105466707 | 105466742 | 1993 | 2027 | 593 | 604 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q13330 | 64 | 80 | 64 | 81 | Alternative sequence | ID=VSP_042207;Note=In isoform 3. TLSVCYKAGPGADNGEEG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6 |
Q13330 | 64 | 80 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Q13330 | 64 | 80 | 1 | 164 | Domain | Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370 |
Q13330 | 512 | 541 | 431 | 715 | Alternative sequence | ID=VSP_001602;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12167865;Dbxref=PMID:12167865 |
Q13330 | 512 | 541 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Q13330 | 512 | 541 | 505 | 514 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FXY |
Q13330 | 512 | 541 | 534 | 543 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FXY |
Q13330 | 512 | 541 | 522 | 522 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1 |
Q13330 | 593 | 604 | 431 | 715 | Alternative sequence | ID=VSP_001602;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12167865;Dbxref=PMID:12167865 |
Q13330 | 593 | 604 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q13330 | 64 | 80 | 64 | 81 | Alternative sequence | ID=VSP_042207;Note=In isoform 3. TLSVCYKAGPGADNGEEG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6 |
Q13330 | 64 | 80 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Q13330 | 64 | 80 | 1 | 164 | Domain | Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q13330 | 64 | 80 | 64 | 81 | Alternative sequence | ID=VSP_042207;Note=In isoform 3. TLSVCYKAGPGADNGEEG->R;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6 |
Q13330 | 64 | 80 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Q13330 | 64 | 80 | 1 | 164 | Domain | Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370 |
Q13330 | 314 | 339 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Q13330 | 314 | 339 | 283 | 335 | Domain | Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624 |
Q13330 | 314 | 339 | 320 | 330 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4BKX |
Q13330 | 512 | 541 | 431 | 715 | Alternative sequence | ID=VSP_001602;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12167865;Dbxref=PMID:12167865 |
Q13330 | 512 | 541 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
Q13330 | 512 | 541 | 505 | 514 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FXY |
Q13330 | 512 | 541 | 534 | 543 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FXY |
Q13330 | 512 | 541 | 522 | 522 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1 |
Q13330 | 593 | 604 | 431 | 715 | Alternative sequence | ID=VSP_001602;Note=In isoform Short. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12167865;Dbxref=PMID:12167865 |
Q13330 | 593 | 604 | 1 | 715 | Chain | ID=PRO_0000083493;Note=Metastasis-associated protein MTA1 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MTA1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MTA1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MTA1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MTA1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MTA1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TARDBP | exon_skip_145482 | -4.252800e-01 | 2.547656e-08 |
CB | U2AF2 | exon_skip_145482 | -4.980000e-01 | 2.781590e-11 |
CB | CNOT4 | exon_skip_145482 | -4.304609e-01 | 1.649540e-08 |
CB | PCBP1 | exon_skip_145482 | -4.005394e-01 | 1.840937e-07 |
CB | PCBP4 | exon_skip_145482 | 5.474082e-01 | 9.873400e-14 |
CB | HNRNPA2B1 | exon_skip_145482 | -4.053956e-01 | 1.264376e-07 |
CB | RBM45 | exon_skip_145482 | 5.499575e-01 | 7.193582e-14 |
CB | PTBP1 | exon_skip_145482 | -4.257182e-01 | 2.456388e-08 |
CB | HNRNPF | exon_skip_145482 | -4.026939e-01 | 1.559450e-07 |
CB | RBM4 | exon_skip_145482 | -5.090824e-01 | 8.484758e-12 |
CB | PCBP4 | exon_skip_293021 | 5.079751e-01 | 8.219643e-12 |
CB | RBM45 | exon_skip_293021 | 6.457124e-01 | 3.960492e-20 |
CB | HNRNPF | exon_skip_117591 | -4.154417e-01 | 5.170775e-08 |
HCC | RBM5 | exon_skip_293021 | -4.313567e-01 | 1.045038e-13 |
HCC | EIF4G2 | exon_skip_293021 | -4.067746e-01 | 3.190230e-12 |
HCC | HNRNPF | exon_skip_293021 | -4.295061e-01 | 1.365051e-13 |
HCC | HNRNPA2B1 | exon_skip_22414 | -4.335815e-01 | 6.119537e-14 |
IFG | ILF2 | exon_skip_293021 | 4.624479e-01 | 1.322065e-02 |
IFG | HNRNPH2 | exon_skip_293021 | 4.753175e-01 | 1.058172e-02 |
IFG | EIF4B | exon_skip_293021 | 4.615899e-01 | 1.341445e-02 |
IFG | ILF2 | exon_skip_22414 | 4.468927e-01 | 3.705685e-02 |
TC | RBMS2 | exon_skip_145482 | -4.692977e-01 | 1.212187e-08 |
TC | SRSF2 | exon_skip_145482 | 4.099106e-01 | 9.595103e-07 |
TC | SFPQ | exon_skip_145482 | 4.131489e-01 | 7.719977e-07 |
TC | PCBP4 | exon_skip_145482 | 5.240284e-01 | 9.604674e-11 |
TC | SRSF5 | exon_skip_145482 | 4.089055e-01 | 1.026028e-06 |
TC | ILF2 | exon_skip_22414 | 4.231958e-01 | 2.470979e-08 |
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RelatedDrugs for MTA1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTA1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |