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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DPP9 |
 Gene summary |
| Gene information | Gene symbol | DPP9 | Gene ID | 91039 |
| Gene name | dipeptidyl peptidase 9 | |
| Synonyms | DP9|DPLP9|DPP IX|DPRP-2|DPRP2 | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | dipeptidyl peptidase 9dipeptidyl peptidase IV-related protein-2dipeptidyl peptidase IXdipeptidyl peptidase-like protein 9 | |
| Modification date | 20200320 | |
| UniProtAcc | A0A2R8YF65, M0QXA6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DPP9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000142002
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000602161.5 | DPP9-225:protein_coding:DPP9 | 1.752232e+00 | 1.279982e+00 | 2.691622e-05 | 2.435028e-04 |
| CB | DOWN | ENST00000594671.5 | DPP9-203:protein_coding:DPP9 | 1.348764e+02 | -8.589507e-01 | 4.531887e-04 | 2.650410e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DPP9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112604 | chr19 | 4714081:4714337:4715529:4715726:4719851:4719941 | 4715529:4715726 |
| exon_skip_131898 | chr19 | 4714246:4714337:4715529:4715726:4719851:4719941 | 4715529:4715726 |
| exon_skip_145239 | chr19 | 4694685:4694823:4695378:4695555:4697551:4697651 | 4695378:4695555 |
| exon_skip_149797 | chr19 | 4702684:4702716:4703886:4704054:4704131:4704151 | 4703886:4704054 |
| exon_skip_168423 | chr19 | 4719923:4719941:4722195:4722304:4722499:4722551 | 4722195:4722304 |
| exon_skip_189215 | chr19 | 4694661:4694823:4695378:4695555:4697551:4697651 | 4695378:4695555 |
| exon_skip_198014 | chr19 | 4714246:4714337:4719203:4719324:4719851:4719941 | 4719203:4719324 |
| exon_skip_24210 | chr19 | 4697551:4697651:4700216:4700273:4702027:4702155 | 4700216:4700273 |
| exon_skip_244271 | chr19 | 4682696:4682838:4683190:4683324:4683477:4683629 | 4683190:4683324 |
| exon_skip_245361 | chr19 | 4719851:4719941:4722195:4722304:4722499:4722551 | 4722195:4722304 |
| exon_skip_275534 | chr19 | 4682696:4682838:4683190:4683324:4683477:4683611 | 4683190:4683324 |
| exon_skip_292893 | chr19 | 4697551:4697651:4700216:4700273:4702027:4702149 | 4700216:4700273 |
| exon_skip_294322 | chr19 | 4697551:4697651:4700216:4700277:4702027:4702149 | 4700216:4700277 |
| exon_skip_296713 | chr19 | 4719923:4719941:4722499:4722551:4723674:4723750 | 4722499:4722551 |
| exon_skip_41493 | chr19 | 4697551:4697651:4700216:4700277:4702027:4702155 | 4700216:4700277 |
| exon_skip_56287 | chr19 | 4679835:4679946:4682696:4682838:4683477:4683629 | 4682696:4682838 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DPP9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000598800 | 4715529 | 4715726 | 3UTR-3UTR |
| ENST00000598800 | 4722499 | 4722551 | 3UTR-3UTR |
| ENST00000598800 | 4682696 | 4682838 | Frame-shift |
| ENST00000598800 | 4695378 | 4695555 | Frame-shift |
| ENST00000598800 | 4700216 | 4700277 | Frame-shift |
| ENST00000598800 | 4703886 | 4704054 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000598800 | 4695378 | 4695555 | Frame-shift |
| ENST00000598800 | 4700216 | 4700277 | Frame-shift |
| ENST00000598800 | 4703886 | 4704054 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000598800 | 4715529 | 4715726 | 3UTR-3UTR |
| ENST00000598800 | 4722499 | 4722551 | 3UTR-3UTR |
| ENST00000598800 | 4695378 | 4695555 | Frame-shift |
| ENST00000598800 | 4700216 | 4700277 | Frame-shift |
| ENST00000598800 | 4703886 | 4704054 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DPP9 |
p-ENSG00000142002_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DPP9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000598800 | 4715529 | 4715726 | hsa-miR-1290 | chr19:4715647-4715654 | 8mer-1a | chr19:4715638-4715656 | 152.00 | -9.85 |
| Mayo | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4493 | chr19:4715703-4715710 | 8mer-1a | chr19:4715694-4715711 | 154.00 | -23.73 |
| Mayo | ENST00000598800 | 4722499 | 4722551 | hsa-miR-3657 | chr19:4722541-4722548 | 8mer-1a | chr19:4722528-4722548 | 151.00 | -21.16 |
| Mayo | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4707-5p | chr19:4715688-4715695 | 8mer-1a | chr19:4715674-4715695 | 150.00 | -28.80 |
| Mayo | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4740-3p | chr19:4715617-4715624 | 8mer-1a | chr19:4715609-4715631 | 169.00 | -36.52 |
| Mayo | ENST00000598800 | 4722499 | 4722551 | hsa-miR-4433a-5p | chr19:4722539-4722546 | 8mer-1a | chr19:4722527-4722547 | 155.00 | -21.45 |
| Mayo | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4763-5p | chr19:4715550-4715557 | 8mer-1a | chr19:4715544-4715568 | 152.00 | -21.86 |
| ROSMAP | ENST00000598800 | 4715529 | 4715726 | hsa-miR-1290 | chr19:4715647-4715654 | 8mer-1a | chr19:4715638-4715656 | 152.00 | -9.85 |
| ROSMAP | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4493 | chr19:4715703-4715710 | 8mer-1a | chr19:4715694-4715711 | 154.00 | -23.73 |
| ROSMAP | ENST00000598800 | 4722499 | 4722551 | hsa-miR-3657 | chr19:4722541-4722548 | 8mer-1a | chr19:4722528-4722548 | 151.00 | -21.16 |
| ROSMAP | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4707-5p | chr19:4715688-4715695 | 8mer-1a | chr19:4715674-4715695 | 150.00 | -28.80 |
| ROSMAP | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4740-3p | chr19:4715617-4715624 | 8mer-1a | chr19:4715609-4715631 | 169.00 | -36.52 |
| ROSMAP | ENST00000598800 | 4722499 | 4722551 | hsa-miR-4433a-5p | chr19:4722539-4722546 | 8mer-1a | chr19:4722527-4722547 | 155.00 | -21.45 |
| ROSMAP | ENST00000598800 | 4715529 | 4715726 | hsa-miR-4763-5p | chr19:4715550-4715557 | 8mer-1a | chr19:4715544-4715568 | 152.00 | -21.86 |
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SNVs in the skipped exons for DPP9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DPP9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPP9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DPP9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_244271 | -5.026453e-01 | 1.464982e-11 |
| CB | PCBP1 | exon_skip_244271 | -4.257982e-01 | 2.201144e-08 |
| CB | HNRNPA2B1 | exon_skip_244271 | -5.181337e-01 | 2.656305e-12 |
| CB | RBM23 | exon_skip_244271 | -4.302041e-01 | 1.517180e-08 |
| CB | FUS | exon_skip_244271 | 5.070974e-01 | 9.046516e-12 |
| CB | RBM4B | exon_skip_244271 | -4.850063e-01 | 9.251276e-11 |
| CB | RBM45 | exon_skip_294322 | 6.055170e-01 | 3.516379e-17 |
| TC | FUS | exon_skip_275534 | 4.358621e-01 | 1.040280e-08 |
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RelatedDrugs for DPP9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPP9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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