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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAP7 |
 Gene summary |
| Gene information | Gene symbol | MAP7 | Gene ID | 9053 |
| Gene name | microtubule associated protein 7 | |
| Synonyms | E-MAP-115|EMAP115 | |
| Cytomap | 6q23.3 | |
| Type of gene | protein-coding | |
| Description | ensconsinMAP-7dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))epithelial microtubule-associated protein of 115 kDa | |
| Modification date | 20200313 | |
| UniProtAcc | A0A087WZ40, Q14244, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MAP7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000135525
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000313543.5 | GIMAP7-201:protein_coding:GIMAP7 | 3.571611e+01 | 1.569300e+00 | 1.133676e-07 | 9.112195e-05 |
| PG | UP | ENST00000313543.5 | GIMAP7-201:protein_coding:GIMAP7 | 5.243593e+01 | 8.785561e-01 | 1.160036e-07 | 1.703814e-05 |
| CB | DOWN | ENST00000354570.7 | MAP7-201:protein_coding:MAP7 | 6.635584e+02 | -1.023550e+00 | 2.495772e-04 | 1.606008e-03 |
| CB | UP | ENST00000438100.6 | MAP7-203:protein_coding:MAP7 | 2.948073e+02 | 1.083853e+00 | 3.550375e-03 | 1.482395e-02 |
| TC | DOWN | ENST00000618822.4 | MAP7-209:protein_coding:MAP7 | 1.353968e+01 | -2.592545e+01 | 6.874868e-66 | 4.728396e-61 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116563 | chr6 | 136377759:136377868:136383671:136383781:136388393:136388510 | 136383671:136383781 |
| exon_skip_127535 | chr6 | 136372501:136372625:136377755:136377868:136383671:136383781 | 136377755:136377868 |
| exon_skip_127874 | chr6 | 136345856:136346079:136356692:136356794:136359820:136359876 | 136356692:136356794 |
| exon_skip_128334 | chr6 | 136377755:136377868:136383671:136383781:136388393:136388510 | 136383671:136383781 |
| exon_skip_135540 | chr6 | 136366327:136366439:136372501:136372625:136377755:136377854 | 136372501:136372625 |
| exon_skip_145921 | chr6 | 136372501:136372625:136377755:136377868:136388393:136388510 | 136377755:136377868 |
| exon_skip_162171 | chr6 | 136366327:136366439:136372501:136372649:136377755:136377854 | 136372501:136372649 |
| exon_skip_193427 | chr6 | 136377755:136377868:136383671:136383781:136388393:136388450 | 136383671:136383781 |
| exon_skip_207931 | chr6 | 136366327:136366439:136372501:136372649:136377755:136377868 | 136372501:136372649 |
| exon_skip_257608 | chr6 | 136377755:136377868:136383671:136383781:136411620:136411697 | 136383671:136383781 |
| exon_skip_26963 | chr6 | 136372501:136372649:136377755:136377868:136383671:136383781 | 136377755:136377868 |
| exon_skip_273256 | chr6 | 136366327:136366439:136372501:136372625:136377755:136377868 | 136372501:136372625 |
| exon_skip_36275 | chr6 | 136421701:136421799:136525832:136525971:136526362:136526606 | 136525832:136525971 |
| exon_skip_60597 | chr6 | 136388393:136388510:136389354:136389517:136411620:136411697 | 136389354:136389517 |
| exon_skip_67297 | chr6 | 136345856:136346079:136356692:136356794:136359820:136359877 | 136356692:136356794 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_273256 | Mayo_CB | 6.797561e-01 | 7.954667e-01 | -1.157106e-01 | 3.529222e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for MAP7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354570 | 136356692 | 136356794 | Frame-shift |
| ENST00000354570 | 136372501 | 136372625 | Frame-shift |
| ENST00000354570 | 136383671 | 136383781 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354570 | 136372501 | 136372625 | Frame-shift |
| ENST00000354570 | 136383671 | 136383781 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354570 | 136356692 | 136356794 | Frame-shift |
| ENST00000354570 | 136372501 | 136372625 | Frame-shift |
| ENST00000354570 | 136389354 | 136389517 | Frame-shift |
| ENST00000354570 | 136377755 | 136377868 | In-frame |
| ENST00000354570 | 136383671 | 136383781 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP7 |
p-ENSG00000135525_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000354570 | 4169 | 749 | 136383671 | 136383781 | 938 | 1047 | 175 | 212 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000354570 | 4169 | 749 | 136383671 | 136383781 | 938 | 1047 | 175 | 212 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000354570 | 4169 | 749 | 136383671 | 136383781 | 938 | 1047 | 175 | 212 |
| ENST00000354570 | 4169 | 749 | 136377755 | 136377868 | 1049 | 1161 | 212 | 250 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14244 | 175 | 212 | 82 | 175 | Alternative sequence | ID=VSP_021316;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q14244 | 175 | 212 | 176 | 212 | Alternative sequence | ID=VSP_021317;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q14244 | 175 | 212 | 2 | 749 | Chain | ID=PRO_0000255949;Note=Ensconsin |
| Q14244 | 175 | 212 | 183 | 183 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 |
| Q14244 | 175 | 212 | 200 | 200 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q14244 | 175 | 212 | 202 | 202 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q14244 | 175 | 212 | 209 | 209 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,E |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14244 | 175 | 212 | 82 | 175 | Alternative sequence | ID=VSP_021316;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q14244 | 175 | 212 | 176 | 212 | Alternative sequence | ID=VSP_021317;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q14244 | 175 | 212 | 2 | 749 | Chain | ID=PRO_0000255949;Note=Ensconsin |
| Q14244 | 175 | 212 | 183 | 183 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 |
| Q14244 | 175 | 212 | 200 | 200 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q14244 | 175 | 212 | 202 | 202 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q14244 | 175 | 212 | 209 | 209 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,E |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14244 | 175 | 212 | 82 | 175 | Alternative sequence | ID=VSP_021316;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q14244 | 175 | 212 | 176 | 212 | Alternative sequence | ID=VSP_021317;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q14244 | 175 | 212 | 2 | 749 | Chain | ID=PRO_0000255949;Note=Ensconsin |
| Q14244 | 175 | 212 | 183 | 183 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 |
| Q14244 | 175 | 212 | 200 | 200 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q14244 | 175 | 212 | 202 | 202 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q14244 | 175 | 212 | 209 | 209 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:18691976,ECO:0000244|PubMed:20068231,E |
| Q14244 | 212 | 250 | 176 | 212 | Alternative sequence | ID=VSP_021317;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.2;Dbxref=PMID:14702039 |
| Q14244 | 212 | 250 | 2 | 749 | Chain | ID=PRO_0000255949;Note=Ensconsin |
| Q14244 | 212 | 250 | 219 | 219 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17924679,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,E |
| Q14244 | 212 | 250 | 231 | 231 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q14244 | 212 | 250 | 235 | 235 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAP7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAP7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAP7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | STG | exon_skip_193427 | 3.086730e-01 | 2.609474e-03 | chr6 | - | 136377755 | 136377868 | 136383671 | 136383781 | 136388393 | 136388450 |
| CDR | MSBB | IFG | exon_skip_273256 | -4.712894e-01 | 1.135552e-02 | chr6 | - | 136366327 | 136366439 | 136372501 | 136372625 | 136377755 | 136377868 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAP7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_273256 | -4.311441e-01 | 1.730657e-08 |
| CB | SNRPA | exon_skip_273256 | -4.900946e-01 | 7.277093e-11 |
| IFG | RALYL | exon_skip_128334 | -4.240103e-01 | 2.453499e-02 |
| IFG | NOVA1 | exon_skip_128334 | -4.646386e-01 | 1.273632e-02 |
| TC | RBM6 | exon_skip_162171 | -4.047859e-01 | 1.227685e-06 |
| TC | RALYL | exon_skip_162171 | 4.016750e-01 | 1.506791e-06 |
| TC | PCBP4 | exon_skip_116563 | 4.405479e-01 | 5.549608e-09 |
| TC | RALYL | exon_skip_116563 | -4.507491e-01 | 2.216178e-09 |
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RelatedDrugs for MAP7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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