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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZNF160 |
Gene summary |
Gene information | Gene symbol | ZNF160 | Gene ID | 90338 |
Gene name | zinc finger protein 160 | |
Synonyms | F11|HKr18|HZF5|KR18 | |
Cytomap | 19q13.41-q13.42 | |
Type of gene | protein-coding | |
Description | zinc finger protein 160KRAB zinc finger protein KR18zinc finger protein 5zinc finger protein HZF5zinc finger protein Kr18 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF160 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000601982.5 | ZNF160-215:protein_coding:ZNF160 | 2.254195e+00 | 1.139701e+00 | 3.254000e-03 | 3.374128e-02 |
CB | UP | ENST00000599637.5 | ZNF160-210:protein_coding:ZNF160 | 5.113065e+00 | 1.343105e+00 | 1.607553e-03 | 7.684525e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF160 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_150139 | chr19 | 53075159:53075183:53086262:53086321:53091637:53091720 | 53086262:53086321 |
exon_skip_151411 | chr19 | 53086262:53086321:53091413:53091553:53091637:53091720 | 53091413:53091553 |
exon_skip_187154 | chr19 | 53070073:53070262:53074140:53074268:53075057:53075183 | 53074140:53074268 |
exon_skip_227567 | chr19 | 53086262:53086321:53091413:53091529:53091637:53091720 | 53091413:53091529 |
exon_skip_232466 | chr19 | 53091637:53091720:53093582:53093637:53103265:53103327 | 53093582:53093637 |
exon_skip_4505 | chr19 | 53086262:53086321:53091413:53091497:53091637:53091720 | 53091413:53091497 |
exon_skip_56382 | chr19 | 53085161:53085218:53085809:53086109:53086262:53086321 | 53085809:53086109 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF160 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000429604 | 53091413 | 53091529 | 3UTR-3UTR |
ENST00000599056 | 53091413 | 53091497 | 3UTR-3UTR |
ENST00000418871 | 53074140 | 53074268 | In-frame |
ENST00000429604 | 53074140 | 53074268 | In-frame |
ENST00000599056 | 53074140 | 53074268 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000429604 | 53091413 | 53091529 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000418871 | 53086262 | 53086321 | 3UTR-3CDS |
ENST00000429604 | 53091413 | 53091529 | 3UTR-3UTR |
ENST00000418871 | 53074140 | 53074268 | In-frame |
ENST00000429604 | 53074140 | 53074268 | In-frame |
ENST00000599056 | 53074140 | 53074268 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF160 |
p-ENSG00000170949_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000418871 | 4236 | 818 | 53074140 | 53074268 | 442 | 569 | 47 | 90 |
ENST00000429604 | 4353 | 818 | 53074140 | 53074268 | 559 | 686 | 47 | 90 |
ENST00000599056 | 4246 | 818 | 53074140 | 53074268 | 444 | 571 | 47 | 90 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000418871 | 4236 | 818 | 53074140 | 53074268 | 442 | 569 | 47 | 90 |
ENST00000429604 | 4353 | 818 | 53074140 | 53074268 | 559 | 686 | 47 | 90 |
ENST00000599056 | 4246 | 818 | 53074140 | 53074268 | 444 | 571 | 47 | 90 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9HCG1 | 47 | 90 | 1 | 818 | Chain | ID=PRO_0000047433;Note=Zinc finger protein 160 |
Q9HCG1 | 47 | 90 | 1 | 818 | Chain | ID=PRO_0000047433;Note=Zinc finger protein 160 |
Q9HCG1 | 47 | 90 | 1 | 818 | Chain | ID=PRO_0000047433;Note=Zinc finger protein 160 |
Q9HCG1 | 47 | 90 | 8 | 79 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
Q9HCG1 | 47 | 90 | 8 | 79 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
Q9HCG1 | 47 | 90 | 8 | 79 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
Q9HCG1 | 47 | 90 | 82 | 82 | Natural variant | ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164 |
Q9HCG1 | 47 | 90 | 82 | 82 | Natural variant | ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164 |
Q9HCG1 | 47 | 90 | 82 | 82 | Natural variant | ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9HCG1 | 47 | 90 | 1 | 818 | Chain | ID=PRO_0000047433;Note=Zinc finger protein 160 |
Q9HCG1 | 47 | 90 | 1 | 818 | Chain | ID=PRO_0000047433;Note=Zinc finger protein 160 |
Q9HCG1 | 47 | 90 | 1 | 818 | Chain | ID=PRO_0000047433;Note=Zinc finger protein 160 |
Q9HCG1 | 47 | 90 | 8 | 79 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
Q9HCG1 | 47 | 90 | 8 | 79 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
Q9HCG1 | 47 | 90 | 8 | 79 | Domain | Note=KRAB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00119 |
Q9HCG1 | 47 | 90 | 82 | 82 | Natural variant | ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164 |
Q9HCG1 | 47 | 90 | 82 | 82 | Natural variant | ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164 |
Q9HCG1 | 47 | 90 | 82 | 82 | Natural variant | ID=VAR_060274;Note=P->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10997877,ECO:0000269|PubMed:11410164;Dbxref=dbSNP:rs8105668,PMID:10997877,PMID:11410164 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF160 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000429604 | 53091413 | 53091529 | hsa-miR-7156-3p | chr19:53091449-53091456 | 8mer-1a | chr19:53091436-53091456 | 170.00 | -28.03 |
Mayo | ENST00000429604 | 53091413 | 53091529 | hsa-miR-6744-3p | chr19:53091507-53091514 | 8mer-1a | chr19:53091505-53091526 | 158.00 | -23.54 |
Mayo | ENST00000429604 | 53091413 | 53091529 | hsa-miR-6765-3p | chr19:53091429-53091436 | 8mer-1a | chr19:53091426-53091447 | 158.00 | -18.20 |
Mayo | ENST00000429604 | 53091413 | 53091529 | hsa-miR-4757-5p | chr19:53091507-53091514 | 8mer-1a | chr19:53091505-53091526 | 158.00 | -23.54 |
Mayo | ENST00000429604 | 53091413 | 53091529 | hsa-miR-10396b-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
Mayo | ENST00000429604 | 53091413 | 53091529 | hsa-miR-10396a-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
MSBB | ENST00000429604 | 53091413 | 53091529 | hsa-miR-7156-3p | chr19:53091449-53091456 | 8mer-1a | chr19:53091436-53091456 | 170.00 | -28.03 |
MSBB | ENST00000429604 | 53091413 | 53091529 | hsa-miR-6744-3p | chr19:53091507-53091514 | 8mer-1a | chr19:53091505-53091526 | 158.00 | -23.54 |
MSBB | ENST00000429604 | 53091413 | 53091529 | hsa-miR-6765-3p | chr19:53091429-53091436 | 8mer-1a | chr19:53091426-53091447 | 158.00 | -18.20 |
MSBB | ENST00000429604 | 53091413 | 53091529 | hsa-miR-4757-5p | chr19:53091507-53091514 | 8mer-1a | chr19:53091505-53091526 | 158.00 | -23.54 |
MSBB | ENST00000429604 | 53091413 | 53091529 | hsa-miR-10396b-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
MSBB | ENST00000429604 | 53091413 | 53091529 | hsa-miR-10396a-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
ROSMAP | ENST00000429604 | 53091413 | 53091529 | hsa-miR-7156-3p | chr19:53091449-53091456 | 8mer-1a | chr19:53091436-53091456 | 170.00 | -28.03 |
ROSMAP | ENST00000599056 | 53091413 | 53091497 | hsa-miR-7156-3p | chr19:53091449-53091456 | 8mer-1a | chr19:53091436-53091456 | 170.00 | -28.03 |
ROSMAP | ENST00000429604 | 53091413 | 53091529 | hsa-miR-6744-3p | chr19:53091507-53091514 | 8mer-1a | chr19:53091505-53091526 | 158.00 | -23.54 |
ROSMAP | ENST00000429604 | 53091413 | 53091529 | hsa-miR-6765-3p | chr19:53091429-53091436 | 8mer-1a | chr19:53091426-53091447 | 158.00 | -18.20 |
ROSMAP | ENST00000599056 | 53091413 | 53091497 | hsa-miR-6765-3p | chr19:53091429-53091436 | 8mer-1a | chr19:53091426-53091447 | 158.00 | -18.20 |
ROSMAP | ENST00000429604 | 53091413 | 53091529 | hsa-miR-4757-5p | chr19:53091507-53091514 | 8mer-1a | chr19:53091505-53091526 | 158.00 | -23.54 |
ROSMAP | ENST00000429604 | 53091413 | 53091529 | hsa-miR-10396b-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
ROSMAP | ENST00000599056 | 53091413 | 53091497 | hsa-miR-10396b-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
ROSMAP | ENST00000429604 | 53091413 | 53091529 | hsa-miR-10396a-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
ROSMAP | ENST00000599056 | 53091413 | 53091497 | hsa-miR-10396a-3p | chr19:53091485-53091492 | 8mer-1a | chr19:53091469-53091492 | 167.00 | -37.52 |
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SNVs in the skipped exons for ZNF160 |
- Differential PSIs between mutated versus non-mutated samples. |
ENSG00000170949.exon_skip_227567.Mayo_TC.WGS.boxplot.svg |
ENSG00000170949.exon_skip_227567.ROSMAP_PCC.WGS.boxplot.svg |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF160 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF160 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF160 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF160 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF160 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |