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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CCNE1 |
Gene summary |
Gene information | Gene symbol | CCNE1 | Gene ID | 898 |
Gene name | cyclin E1 | |
Synonyms | CCNE|pCCNE1 | |
Cytomap | 19q12 | |
Type of gene | protein-coding | |
Description | G1/S-specific cyclin-E1 | |
Modification date | 20200329 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CCNE1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000574121.1 | CCNE1-204:retained_intron:CCNE1 | 5.937784e+01 | -8.843077e-01 | 7.081092e-10 | 3.281813e-08 |
CB | UP | ENST00000586912.1 | CCNE1-207:retained_intron:CCNE1 | 1.467652e+00 | 8.416829e-01 | 2.661910e-04 | 1.696059e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CCNE1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_265187 | chr19 | 29821722:29821817:29821996:29822130:29822240:29822351 | 29821996:29822130 |
exon_skip_267088 | chr19 | 29812004:29812152:29812532:29812578:29812689:29812776 | 29812532:29812578 |
exon_skip_294061 | chr19 | 29817406:29817541:29820702:29820848:29821722:29821768 | 29820702:29820848 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CCNE1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000262643 | 29820702 | 29820848 | In-frame |
ENST00000262643 | 29821996 | 29822130 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000262643 | 29820702 | 29820848 | In-frame |
ENST00000262643 | 29821996 | 29822130 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CCNE1 |
p-ENSG00000105173_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000262643 | 2060 | 410 | 29820702 | 29820848 | 743 | 888 | 154 | 203 |
ENST00000262643 | 2060 | 410 | 29821996 | 29822130 | 986 | 1119 | 235 | 280 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000262643 | 2060 | 410 | 29820702 | 29820848 | 743 | 888 | 154 | 203 |
ENST00000262643 | 2060 | 410 | 29821996 | 29822130 | 986 | 1119 | 235 | 280 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P24864 | 154 | 203 | 154 | 196 | Alternative sequence | ID=VSP_001253;Note=In isoform E1S. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P24864 | 154 | 203 | 1 | 410 | Chain | ID=PRO_0000080449;Note=G1/S-specific cyclin-E1 |
P24864 | 154 | 203 | 142 | 158 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 154 | 203 | 163 | 179 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 154 | 203 | 185 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 154 | 203 | 188 | 203 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 265 | 267 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 1 | 410 | Chain | ID=PRO_0000080449;Note=G1/S-specific cyclin-E1 |
P24864 | 235 | 280 | 223 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 246 | 257 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 272 | 287 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 237 | 239 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P24864 | 154 | 203 | 154 | 196 | Alternative sequence | ID=VSP_001253;Note=In isoform E1S. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
P24864 | 154 | 203 | 1 | 410 | Chain | ID=PRO_0000080449;Note=G1/S-specific cyclin-E1 |
P24864 | 154 | 203 | 142 | 158 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 154 | 203 | 163 | 179 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 154 | 203 | 185 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 154 | 203 | 188 | 203 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 265 | 267 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 1 | 410 | Chain | ID=PRO_0000080449;Note=G1/S-specific cyclin-E1 |
P24864 | 235 | 280 | 223 | 236 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 246 | 257 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 272 | 287 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
P24864 | 235 | 280 | 237 | 239 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W98 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CCNE1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CCNE1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CCNE1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCNE1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CCNE1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CCNE1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNE1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |