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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CCNC |
Gene summary |
Gene information | Gene symbol | CCNC | Gene ID | 892 |
Gene name | cyclin C | |
Synonyms | CycC|SRB11|hSRB11 | |
Cytomap | 6q16.2 | |
Type of gene | protein-coding | |
Description | cyclin-CSRB11 homolog | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CCNC |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | DOWN | ENST00000519617.1 | CCNC-208:retained_intron:CCNC | 6.385325e+00 | -9.609305e-01 | 1.930816e-04 | 1.618589e-02 |
CB | UP | ENST00000627680.2 | CCNC-219:protein_coding:CCNC | 4.232814e+00 | 1.219527e+00 | 1.146534e-02 | 3.889147e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CCNC |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109913 | chr6 | 99542502:99543609:99544179:99544273:99545112:99545230 | 99544179:99544273 |
exon_skip_121755 | chr6 | 99546395:99546474:99549508:99549575:99550218:99550309 | 99549508:99549575 |
exon_skip_146745 | chr6 | 99546395:99546474:99549312:99549399:99549508:99549575 | 99549312:99549399 |
exon_skip_146747 | chr6 | 99561597:99561681:99562842:99562948:99568496:99568660 | 99562842:99562948 |
exon_skip_150512 | chr6 | 99545205:99545230:99546395:99546474:99549508:99549572 | 99546395:99546474 |
exon_skip_155346 | chr6 | 99549508:99549575:99550218:99550309:99550993:99551028 | 99550218:99550309 |
exon_skip_180336 | chr6 | 99561597:99561681:99562842:99562948:99568496:99568623 | 99562842:99562948 |
exon_skip_196961 | chr6 | 99561367:99561436:99561597:99561681:99568496:99568623 | 99561597:99561681 |
exon_skip_20027 | chr6 | 99546395:99546474:99549312:99549399:99549508:99549572 | 99549312:99549399 |
exon_skip_21985 | chr6 | 99543475:99543609:99544206:99544273:99545112:99545230 | 99544206:99544273 |
exon_skip_252062 | chr6 | 99543464:99543609:99544206:99544273:99545112:99545230 | 99544206:99544273 |
exon_skip_265308 | chr6 | 99561367:99561436:99561597:99561681:99562842:99562948 | 99561597:99561681 |
exon_skip_285414 | chr6 | 99561367:99561436:99562842:99562948:99568496:99568623 | 99562842:99562948 |
exon_skip_36303 | chr6 | 99546395:99546474:99549508:99549572:99550218:99550309 | 99549508:99549572 |
exon_skip_41103 | chr6 | 99543475:99543609:99544179:99544273:99545112:99545230 | 99544179:99544273 |
exon_skip_47553 | chr6 | 99550994:99551028:99551840:99551895:99558497:99558548 | 99551840:99551895 |
exon_skip_66077 | chr6 | 99561369:99561436:99561597:99561681:99562842:99562948 | 99561597:99561681 |
exon_skip_86416 | chr6 | 99558501:99558548:99561367:99561436:99561597:99561658 | 99561367:99561436 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CCNC |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000520429 | 99546395 | 99546474 | Frame-shift |
ENST00000520429 | 99550218 | 99550309 | Frame-shift |
ENST00000520429 | 99551840 | 99551895 | Frame-shift |
ENST00000520429 | 99561597 | 99561681 | Frame-shift |
ENST00000520429 | 99562842 | 99562948 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000520429 | 99546395 | 99546474 | Frame-shift |
ENST00000520429 | 99550218 | 99550309 | Frame-shift |
ENST00000520429 | 99561597 | 99561681 | Frame-shift |
ENST00000520429 | 99562842 | 99562948 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000520429 | 99546395 | 99546474 | Frame-shift |
ENST00000520429 | 99549508 | 99549575 | Frame-shift |
ENST00000520429 | 99550218 | 99550309 | Frame-shift |
ENST00000520429 | 99561367 | 99561436 | Frame-shift |
ENST00000520429 | 99561597 | 99561681 | Frame-shift |
ENST00000520429 | 99562842 | 99562948 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CCNC |
p-ENSG00000112237_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CCNC |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CCNC |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CCNC |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCNC |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CCNC |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | DAZAP1 | exon_skip_86416 | -5.102325e-01 | 1.615428e-11 |
CB | TARDBP | exon_skip_86416 | -5.581409e-01 | 6.601780e-14 |
CB | ELAVL1 | exon_skip_86416 | -4.411101e-01 | 1.150542e-08 |
CB | RBM6 | exon_skip_86416 | -4.603893e-01 | 2.128555e-09 |
CB | TRA2A | exon_skip_86416 | -5.958422e-01 | 4.486688e-16 |
CB | FUBP1 | exon_skip_86416 | -5.504438e-01 | 1.695644e-13 |
CB | KHSRP | exon_skip_86416 | -4.129413e-01 | 1.129297e-07 |
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RelatedDrugs for CCNC |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNC |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |