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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for AP1S2 |
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Gene information | Gene symbol | AP1S2 | Gene ID | 8905 |
Gene name | adaptor related protein complex 1 subunit sigma 2 | |
Synonyms | DC22|MRX59|MRXS21|MRXS5|MRXSF|PGS|SIGMA1B | |
Cytomap | Xp22.2 | |
Type of gene | protein-coding | |
Description | AP-1 complex subunit sigma-2adapter-related protein complex 1 sigma-1B subunitadaptor protein complex AP-1 sigma-1B subunitadaptor related protein complex 1 sigma 2 subunitadaptor-related protein complex 1 subunit sigma-1Bclathrin adaptor complex AP1 | |
Modification date | 20200320 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for AP1S2 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
DLPFC | DOWN | ENST00000672063.1 | AP1S2-208:nonsense_mediated_decay:AP1S2 | 9.376535e+00 | -8.209084e-01 | 1.462274e-03 | 4.317176e-02 |
PG | UP | ENST00000329235.6 | AP1S2-201:protein_coding:AP1S2 | 1.682549e+02 | 8.827799e-01 | 5.966290e-10 | 2.813106e-07 |
PG | UP | ENST00000450644.2 | AP1S2-203:protein_coding:AP1S2 | 2.099430e+01 | 9.722438e-01 | 1.616021e-03 | 2.055319e-02 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for AP1S2 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_106445 | chrX | 15827242:15827372:15828192:15828200:15845379:15845516 | 15828192:15828200 |
exon_skip_122098 | chrX | 15827029:15827372:15828192:15828200:15845379:15845516 | 15828192:15828200 |
exon_skip_126858 | chrX | 15827313:15827372:15828192:15828200:15840497:15840591 | 15828192:15828200 |
exon_skip_12841 | chrX | 15831452:15831568:15833444:15833524:15845379:15845516 | 15833444:15833524 |
exon_skip_136074 | chrX | 15828192:15828200:15831452:15831568:15845379:15845516 | 15831452:15831568 |
exon_skip_142125 | chrX | 15826892:15827372:15840497:15840591:15845379:15845516 | 15840497:15840591 |
exon_skip_177381 | chrX | 15826892:15827372:15828192:15828200:15840497:15840591 | 15828192:15828200 |
exon_skip_227377 | chrX | 15828192:15828200:15840497:15840591:15845379:15845516 | 15840497:15840591 |
exon_skip_270893 | chrX | 15827313:15827372:15828192:15828200:15845379:15845516 | 15828192:15828200 |
exon_skip_30192 | chrX | 15827313:15827372:15840497:15840591:15845379:15845516 | 15840497:15840591 |
exon_skip_63474 | chrX | 15827029:15827372:15828192:15828200:15831452:15831568 | 15828192:15828200 |
exon_skip_99325 | chrX | 15831290:15833007:15833444:15833524:15845379:15845516 | 15833444:15833524 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_106445 | ROSMAP_PCC | 6.181250e-01 | 7.284524e-01 | -1.103274e-01 | 8.164501e-05 |
exon_skip_122098 | MSBB_STG | 5.443750e-01 | 7.150000e-01 | -1.706250e-01 | 1.614668e-02 |
exon_skip_122098 | MSBB_PG | 4.135507e-01 | 6.675472e-01 | -2.539964e-01 | 8.313806e-07 |
exon_skip_122098 | MSBB_IFG | 4.829412e-01 | 6.336364e-01 | -1.506952e-01 | 4.049546e-02 |
exon_skip_106445 | Mayo_TC | 3.357317e-01 | 5.238961e-01 | -1.881644e-01 | 7.466622e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for AP1S2 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for AP1S2 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in AP1S2 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for AP1S2 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for AP1S2 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AP1S2 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for AP1S2 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | NUP42 | exon_skip_106445 | 5.156486e-01 | 5.638910e-12 |
CB | SRSF9 | exon_skip_106445 | 4.073071e-01 | 1.313283e-07 |
HCC | ZNF326 | exon_skip_122098 | -6.328803e-01 | 7.586747e-32 |
HCC | TRA2A | exon_skip_122098 | -4.303348e-01 | 1.091527e-13 |
HCC | SRSF1 | exon_skip_122098 | -4.333434e-01 | 7.044467e-14 |
IFG | NUP42 | exon_skip_122098 | 4.245585e-01 | 2.433089e-02 |
PCC | ZNF326 | exon_skip_106445 | -5.135146e-01 | 1.161821e-15 |
STG | NUP42 | exon_skip_122098 | 4.793574e-01 | 2.300863e-06 |
STG | SRSF9 | exon_skip_122098 | 4.100479e-01 | 7.261757e-05 |
TC | ZNF326 | exon_skip_106445 | -4.386970e-01 | 7.293292e-09 |
TC | NUP42 | exon_skip_106445 | 6.411543e-01 | 8.749773e-20 |
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RelatedDrugs for AP1S2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AP1S2 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |