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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FUBP1 |
 Gene summary |
| Gene information | Gene symbol | FUBP1 | Gene ID | 8880 |
| Gene name | far upstream element binding protein 1 | |
| Synonyms | FBP|FUBP|hDH V | |
| Cytomap | 1p31.1 | |
| Type of gene | protein-coding | |
| Description | far upstream element-binding protein 1DNA helicase VFUSE binding protein 1epididymis secretory sperm binding proteinfar upstream element (FUSE) binding protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FUBP1 | GO:0010628 | positive regulation of gene expression | 19087307 |
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Gene structures and expression levels for FUBP1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000162613
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000480673.5 | FUBP1-207:lncRNA:FUBP1 | 8.657958e+01 | -1.387613e+00 | 1.395127e-08 | 3.999817e-07 |
| CB | UP | ENST00000370767.5 | FUBP1-202:protein_coding:FUBP1 | 5.672744e+02 | 8.563142e-01 | 7.172312e-08 | 1.603767e-06 |
| CB | DOWN | ENST00000474632.5 | FUBP1-206:lncRNA:FUBP1 | 2.733853e+01 | -9.528486e-01 | 1.334230e-07 | 2.717005e-06 |
| CB | UP | ENST00000487684.1 | FUBP1-209:lncRNA:FUBP1 | 9.667259e+01 | 8.012985e-01 | 1.552383e-07 | 3.078855e-06 |
| CB | UP | ENST00000294623.8 | FUBP1-201:nonsense_mediated_decay:FUBP1 | 7.021032e+02 | 8.818328e-01 | 1.599873e-07 | 3.156418e-06 |
| CB | UP | ENST00000470287.1 | FUBP1-205:lncRNA:FUBP1 | 6.863653e+00 | 8.339444e-01 | 2.785528e-06 | 3.582258e-05 |
| CB | DOWN | ENST00000488814.5 | FUBP1-210:lncRNA:FUBP1 | 8.210926e+00 | -8.556382e-01 | 1.566188e-03 | 7.523030e-03 |
| TC | DOWN | ENST00000480673.5 | FUBP1-207:lncRNA:FUBP1 | 3.228486e+01 | -1.384732e+00 | 9.556762e-09 | 8.671438e-07 |
| TC | DOWN | ENST00000488814.5 | FUBP1-210:lncRNA:FUBP1 | 5.868790e+00 | -1.156605e+00 | 1.766944e-03 | 1.526421e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FUBP1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_12946 | chr1 | 77966694:77966751:77966884:77966955:77967049:77967098 | 77966884:77966955 |
| exon_skip_153526 | chr1 | 77946530:77946576:77947453:77947552:77949155:77949267 | 77947453:77947552 |
| exon_skip_167207 | chr1 | 77968165:77968203:77969022:77969084:77969925:77970015 | 77969022:77969084 |
| exon_skip_244752 | chr1 | 77965069:77965231:77966694:77966751:77966884:77966955 | 77966694:77966751 |
| exon_skip_286477 | chr1 | 77956572:77956700:77960184:77960263:77960344:77960495 | 77960184:77960263 |
| exon_skip_35568 | chr1 | 77946530:77946576:77947453:77947547:77949155:77949267 | 77947453:77947547 |
| exon_skip_77229 | chr1 | 77944055:77944269:77945506:77945642:77946530:77946576 | 77945506:77945642 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_35568 | Mayo_CB | 6.877922e-01 | 8.158182e-01 | -1.280260e-01 | 1.101157e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for FUBP1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370768 | 77966694 | 77966751 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370768 | 77960184 | 77960263 | Frame-shift |
| ENST00000370768 | 77966694 | 77966751 | Frame-shift |
| ENST00000370768 | 77966884 | 77966955 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FUBP1 |
p-ENSG00000162613_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370768 | 2395 | 644 | 77966884 | 77966955 | 426 | 496 | 114 | 138 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96AE4 | 114 | 138 | 133 | 136 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ |
| Q96AE4 | 114 | 138 | 2 | 644 | Chain | ID=PRO_0000050135;Note=Far upstream element-binding protein 1 |
| Q96AE4 | 114 | 138 | 100 | 164 | Domain | Note=KH 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00117 |
| Q96AE4 | 114 | 138 | 112 | 116 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ |
| Q96AE4 | 114 | 138 | 118 | 120 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ |
| Q96AE4 | 114 | 138 | 121 | 130 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LIJ |
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3'-UTR located exon skipping events that lost miRNA binding sites in FUBP1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FUBP1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FUBP1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FUBP1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FUBP1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_77229 | -4.296329e-01 | 1.592646e-08 |
| CB | CNOT4 | exon_skip_167207 | -4.563182e-01 | 1.494105e-09 |
| CB | HNRNPA2B1 | exon_skip_167207 | -4.662087e-01 | 5.894034e-10 |
| FL | HNRNPH2 | exon_skip_167207 | 4.060175e-01 | 4.264509e-09 |
| HCC | RBM5 | exon_skip_167207 | -4.704865e-01 | 2.180248e-16 |
| HCC | HNRNPA2B1 | exon_skip_167207 | -4.088318e-01 | 2.206309e-12 |
| HCC | SRSF4 | exon_skip_167207 | -4.107579e-01 | 1.700091e-12 |
| HCC | HNRNPF | exon_skip_167207 | -4.382394e-01 | 3.422135e-14 |
| IFG | CNOT4 | exon_skip_167207 | -4.237653e-01 | 2.761324e-02 |
| IFG | RBM5 | exon_skip_167207 | -6.539292e-01 | 2.160901e-04 |
| IFG | SNRPA | exon_skip_167207 | -4.117469e-01 | 3.284673e-02 |
| IFG | HNRNPA2B1 | exon_skip_167207 | -4.420672e-01 | 2.095739e-02 |
| IFG | SRSF1 | exon_skip_167207 | -4.237241e-01 | 2.762995e-02 |
| IFG | SRSF4 | exon_skip_167207 | -4.096959e-01 | 3.381456e-02 |
| TC | SRSF2 | exon_skip_167207 | 4.159479e-01 | 4.499484e-08 |
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RelatedDrugs for FUBP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FUBP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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