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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KAT2B |
 Gene summary |
| Gene information | Gene symbol | KAT2B | Gene ID | 8850 |
| Gene name | lysine acetyltransferase 2B | |
| Synonyms | CAF|P/CAF|PCAF | |
| Cytomap | 3p24.3 | |
| Type of gene | protein-coding | |
| Description | histone acetyltransferase KAT2BCREBBP-associated factorK(lysine) acetyltransferase 2Bhistone acetylase PCAFhistone acetyltransferase PCAFp300/CBP-associated factorspermidine acetyltransferase KAT2B | |
| Modification date | 20200313 | |
| UniProtAcc | Q92831, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| KAT2B | GO:0006338 | chromatin remodeling | 17707232 |
| KAT2B | GO:0006473 | protein acetylation | 15273251|26867678 |
| KAT2B | GO:0008285 | negative regulation of cell proliferation | 8684459 |
| KAT2B | GO:0010835 | regulation of protein ADP-ribosylation | 19470756 |
| KAT2B | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| KAT2B | GO:0018393 | internal peptidyl-lysine acetylation | 23932781|27796307|29174768 |
| KAT2B | GO:0018394 | peptidyl-lysine acetylation | 19303849|19470756 |
| KAT2B | GO:0032869 | cellular response to insulin stimulus | 19303849 |
| KAT2B | GO:0043966 | histone H3 acetylation | 18838386 |
| KAT2B | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19470756 |
| KAT2B | GO:0046600 | negative regulation of centriole replication | 27796307 |
| KAT2B | GO:2000233 | negative regulation of rRNA processing | 26867678 |
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Gene structures and expression levels for KAT2B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000114166
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KAT2B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100153 | chr3 | 20125905:20126113:20127423:20127549:20136942:20137052 | 20127423:20127549 |
| exon_skip_119265 | chr3 | 20072333:20072459:20095263:20095408:20099862:20099954 | 20095263:20095408 |
| exon_skip_133458 | chr3 | 20148248:20148306:20148403:20148487:20152332:20152373 | 20148403:20148487 |
| exon_skip_134312 | chr3 | 20099862:20099954:20101287:20101468:20111596:20111787 | 20101287:20101468 |
| exon_skip_135128 | chr3 | 20146316:20146430:20147963:20147999:20148243:20148306 | 20147963:20147999 |
| exon_skip_177703 | chr3 | 20095263:20095408:20099862:20099954:20101287:20101468 | 20099862:20099954 |
| exon_skip_179965 | chr3 | 20119598:20119723:20122668:20122804:20125905:20126113 | 20122668:20122804 |
| exon_skip_196505 | chr3 | 20040698:20040780:20072333:20072459:20095263:20095387 | 20072333:20072459 |
| exon_skip_21457 | chr3 | 20125993:20126113:20127423:20127549:20136942:20137052 | 20127423:20127549 |
| exon_skip_274887 | chr3 | 20040698:20040780:20072333:20072459:20095263:20095408 | 20072333:20072459 |
| exon_skip_291509 | chr3 | 20140221:20140364:20146316:20146430:20147963:20147999 | 20146316:20146430 |
| exon_skip_33837 | chr3 | 20125921:20126113:20127423:20127549:20136942:20137052 | 20127423:20127549 |
| exon_skip_50064 | chr3 | 20148248:20148306:20148403:20148487:20152332:20154404 | 20148403:20148487 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for KAT2B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263754 | 20101287 | 20101468 | Frame-shift |
| ENST00000263754 | 20127423 | 20127549 | Frame-shift |
| ENST00000263754 | 20146316 | 20146430 | Frame-shift |
| ENST00000263754 | 20148403 | 20148487 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263754 | 20101287 | 20101468 | Frame-shift |
| ENST00000263754 | 20127423 | 20127549 | Frame-shift |
| ENST00000263754 | 20148403 | 20148487 | Frame-shift |
| ENST00000263754 | 20099862 | 20099954 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263754 | 20095263 | 20095408 | Frame-shift |
| ENST00000263754 | 20101287 | 20101468 | Frame-shift |
| ENST00000263754 | 20122668 | 20122804 | Frame-shift |
| ENST00000263754 | 20127423 | 20127549 | Frame-shift |
| ENST00000263754 | 20146316 | 20146430 | Frame-shift |
| ENST00000263754 | 20147963 | 20147999 | Frame-shift |
| ENST00000263754 | 20148403 | 20148487 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for KAT2B |
p-ENSG00000114166_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263754 | 4850 | 832 | 20099862 | 20099954 | 1033 | 1124 | 192 | 223 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q92831 | 192 | 223 | 1 | 832 | Chain | ID=PRO_0000211208;Note=Histone acetyltransferase KAT2B |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in KAT2B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KAT2B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KAT2B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KAT2B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KAT2B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_50064 | -5.522062e-01 | 4.511625e-14 |
| CB | SNRPA | exon_skip_50064 | -4.041072e-01 | 1.274667e-07 |
| CB | FUBP1 | exon_skip_50064 | -4.704587e-01 | 3.915875e-10 |
| IFG | KHDRBS2 | exon_skip_50064 | -4.386605e-01 | 1.953781e-02 |
| IFG | FUBP1 | exon_skip_50064 | -4.237735e-01 | 2.462358e-02 |
| IFG | SRSF9 | exon_skip_50064 | -4.196791e-01 | 2.619712e-02 |
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RelatedDrugs for KAT2B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KAT2B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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