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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for INPP4B |
 Gene summary |
| Gene information | Gene symbol | INPP4B | Gene ID | 8821 |
| Gene name | inositol polyphosphate-4-phosphatase type II B | |
| Synonyms | - | |
| Cytomap | 4q31.21 | |
| Type of gene | protein-coding | |
| Description | inositol polyphosphate 4-phosphatase type IIinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDatype II inositol 3,4-bisphosphate 4-phosphatase | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 21115102(Biochemical and Molecular Aspects of Aluminium Chloride-Induced Neurotoxicity in Mice and the Protective Role of Crocus Sativus L. Extraction and Honey Syrup) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for INPP4B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000109452
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for INPP4B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_11151 | chr4 | 142405305:142405324:142425207:142425263:142429173:142429217 | 142425207:142425263 |
| exon_skip_124649 | chr4 | 142237864:142238011:142260492:142260564:142270663:142270774 | 142260492:142260564 |
| exon_skip_143370 | chr4 | 142654512:142654680:142660777:142660896:142725839:142725901 | 142660777:142660896 |
| exon_skip_144141 | chr4 | 142305458:142305537:142314712:142314762:142402938:142403009 | 142314712:142314762 |
| exon_skip_157577 | chr4 | 142405305:142405324:142423696:142423817:142429173:142429217 | 142423696:142423817 |
| exon_skip_160143 | chr4 | 142145840:142145996:142160358:142160561:142173632:142173809 | 142160358:142160561 |
| exon_skip_162489 | chr4 | 142462663:142462726:142467957:142468055:142725839:142725901 | 142467957:142468055 |
| exon_skip_205321 | chr4 | 142462663:142462726:142660777:142660896:142725839:142725901 | 142660777:142660896 |
| exon_skip_270480 | chr4 | 142086144:142086256:142096085:142096193:142108093:142108190 | 142096085:142096193 |
| exon_skip_91986 | chr4 | 142314712:142314762:142347374:142347556:142402938:142403009 | 142347374:142347556 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for INPP4B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000513000 | 142467957 | 142468055 | 3UTR-3UTR |
| ENST00000262992 | 142160358 | 142160561 | In-frame |
| ENST00000508116 | 142160358 | 142160561 | In-frame |
| ENST00000513000 | 142160358 | 142160561 | In-frame |
| ENST00000262992 | 142314712 | 142314762 | In-frame |
| ENST00000508116 | 142314712 | 142314762 | In-frame |
| ENST00000513000 | 142314712 | 142314762 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262992 | 142160358 | 142160561 | In-frame |
| ENST00000508116 | 142160358 | 142160561 | In-frame |
| ENST00000513000 | 142160358 | 142160561 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262992 | 142260492 | 142260564 | Frame-shift |
| ENST00000508116 | 142260492 | 142260564 | Frame-shift |
| ENST00000513000 | 142260492 | 142260564 | Frame-shift |
| ENST00000262992 | 142160358 | 142160561 | In-frame |
| ENST00000508116 | 142160358 | 142160561 | In-frame |
| ENST00000513000 | 142160358 | 142160561 | In-frame |
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Infer the effects of exon skipping event on protein functional features for INPP4B |
p-ENSG00000109452_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262992 | 3758 | 924 | 142314712 | 142314762 | 590 | 639 | 124 | 140 |
| ENST00000508116 | 3182 | 924 | 142314712 | 142314762 | 726 | 775 | 124 | 140 |
| ENST00000513000 | 8848 | 924 | 142314712 | 142314762 | 807 | 856 | 124 | 140 |
| ENST00000262992 | 3758 | 924 | 142160358 | 142160561 | 1577 | 1779 | 453 | 520 |
| ENST00000508116 | 3182 | 924 | 142160358 | 142160561 | 1713 | 1915 | 453 | 520 |
| ENST00000513000 | 8848 | 924 | 142160358 | 142160561 | 1794 | 1996 | 453 | 520 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262992 | 3758 | 924 | 142160358 | 142160561 | 1577 | 1779 | 453 | 520 |
| ENST00000508116 | 3182 | 924 | 142160358 | 142160561 | 1713 | 1915 | 453 | 520 |
| ENST00000513000 | 8848 | 924 | 142160358 | 142160561 | 1794 | 1996 | 453 | 520 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262992 | 3758 | 924 | 142160358 | 142160561 | 1577 | 1779 | 453 | 520 |
| ENST00000508116 | 3182 | 924 | 142160358 | 142160561 | 1713 | 1915 | 453 | 520 |
| ENST00000513000 | 8848 | 924 | 142160358 | 142160561 | 1794 | 1996 | 453 | 520 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15327 | 124 | 140 | 125 | 131 | Alternative sequence | ID=VSP_047696;Note=In isoform 2. VRTSVLP->IANSSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 124 | 140 | 125 | 131 | Alternative sequence | ID=VSP_047696;Note=In isoform 2. VRTSVLP->IANSSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 124 | 140 | 125 | 131 | Alternative sequence | ID=VSP_047696;Note=In isoform 2. VRTSVLP->IANSSRI;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 124 | 140 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 124 | 140 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 124 | 140 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 124 | 140 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 124 | 140 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 124 | 140 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 124 | 140 | 25 | 149 | Domain | Note=C2 |
| O15327 | 124 | 140 | 25 | 149 | Domain | Note=C2 |
| O15327 | 124 | 140 | 25 | 149 | Domain | Note=C2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 132 | 924 | Alternative sequence | ID=VSP_047697;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
| O15327 | 453 | 520 | 1 | 924 | Chain | ID=PRO_0000190235;Note=Type II inositol 3%2C4-bisphosphate 4-phosphatase |
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3'-UTR located exon skipping events that lost miRNA binding sites in INPP4B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| ROSMAP | ENST00000513000 | 142467957 | 142468055 | hsa-miR-1278 | chr4:142468033-142468040 | 8mer-1a | chr4:142468025-142468048 | 154.00 | -21.35 |
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SNVs in the skipped exons for INPP4B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for INPP4B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for INPP4B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for INPP4B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for INPP4B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INPP4B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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