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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIM24 |
 Gene summary |
| Gene information | Gene symbol | TRIM24 | Gene ID | 8805 |
| Gene name | tripartite motif containing 24 | |
| Synonyms | PTC6|RNF82|TF1A|TIF1|TIF1A|TIF1ALPHA|hTIF1 | |
| Cytomap | 7q33-q34 | |
| Type of gene | protein-coding | |
| Description | transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A024R784, O15164, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM24 | GO:0016567 | protein ubiquitination | 19556538 |
| TRIM24 | GO:0071391 | cellular response to estrogen stimulus | 21164480 |
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Gene structures and expression levels for TRIM24 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000122779
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIM24 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116872 | chr7 | 138504290:138504408:138515212:138515359:138519189:138519321 | 138515212:138515359 |
| exon_skip_152346 | chr7 | 138567481:138567654:138570830:138571003:138573507:138573642 | 138570830:138571003 |
| exon_skip_161036 | chr7 | 138554770:138554966:138556269:138556398:138567481:138567654 | 138556269:138556398 |
| exon_skip_201026 | chr7 | 138515212:138515359:138519189:138519321:138525241:138525314 | 138519189:138519321 |
| exon_skip_221041 | chr7 | 138538657:138538803:138551063:138551180:138554698:138554864 | 138551063:138551180 |
| exon_skip_234535 | chr7 | 138579204:138579532:138580562:138580694:138581697:138581771 | 138580562:138580694 |
| exon_skip_268129 | chr7 | 138573507:138573642:138576373:138576445:138577420:138577588 | 138576373:138576445 |
| exon_skip_28461 | chr7 | 138570830:138571003:138573507:138573642:138576373:138576445 | 138573507:138573642 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM24 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343526 | 138515212 | 138515359 | Frame-shift |
| ENST00000343526 | 138573507 | 138573642 | Frame-shift |
| ENST00000343526 | 138576373 | 138576445 | Frame-shift |
| ENST00000343526 | 138580562 | 138580694 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343526 | 138515212 | 138515359 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343526 | 138515212 | 138515359 | Frame-shift |
| ENST00000343526 | 138519189 | 138519321 | Frame-shift |
| ENST00000343526 | 138551063 | 138551180 | Frame-shift |
| ENST00000343526 | 138573507 | 138573642 | Frame-shift |
| ENST00000343526 | 138576373 | 138576445 | Frame-shift |
| ENST00000343526 | 138570830 | 138571003 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIM24 |
p-ENSG00000122779_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000343526 | 8427 | 1050 | 138570830 | 138571003 | 1921 | 2093 | 568 | 626 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15164 | 568 | 626 | 1 | 1050 | Chain | ID=PRO_0000056390;Note=Transcription intermediary factor 1-alpha |
| O15164 | 568 | 626 | 600 | 600 | Sequence conflict | Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| O15164 | 568 | 626 | 608 | 608 | Sequence conflict | Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIM24 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRIM24 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIM24 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM24 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIM24 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_268129 | 4.725151e-01 | 2.547819e-09 |
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RelatedDrugs for TRIM24 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM24 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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