|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for ADAM9 |
 Gene summary |
| Gene information | Gene symbol | ADAM9 | Gene ID | 8754 |
| Gene name | ADAM metallopeptidase domain 9 | |
| Synonyms | CORD9|MCMP|MDC9|Mltng | |
| Cytomap | 8p11.22 | |
| Type of gene | protein-coding | |
| Description | disintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 19237226(Promoter Polymorphisms Which Regulate ADAM9 Transcription Are Protective Against Sporadic Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ADAM9 | GO:0000186 | activation of MAPKK activity | 17704059 |
| ADAM9 | GO:0006509 | membrane protein ectodomain proteolysis | 9920899 |
| ADAM9 | GO:0034612 | response to tumor necrosis factor | 11831872 |
| ADAM9 | GO:0050714 | positive regulation of protein secretion | 17704059 |
Top |
Gene structures and expression levels for ADAM9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000168615
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000468065.5 | ADAM9-204:nonsense_mediated_decay:ADAM9 | 6.720835e+01 | -2.702729e+00 | 6.627303e-03 | 2.480413e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ADAM9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116650 | chr8 | 39082641:39082721:39082968:39083073:39090047:39090188 | 39082968:39083073 |
| exon_skip_116762 | chr8 | 39077228:39077411:39082641:39082721:39090047:39090188 | 39082641:39082721 |
| exon_skip_137290 | chr8 | 39082968:39083073:39090047:39090188:39091259:39091290 | 39090047:39090188 |
| exon_skip_148525 | chr8 | 39055615:39055772:39071298:39071403:39077228:39077411 | 39071298:39071403 |
| exon_skip_160339 | chr8 | 39082968:39083073:39091259:39091346:39101863:39101930 | 39091259:39091346 |
| exon_skip_197815 | chr8 | 39082968:39083073:39090047:39090188:39091259:39091346 | 39090047:39090188 |
| exon_skip_219447 | chr8 | 39023156:39023325:39025803:39025884:39026677:39026810 | 39025803:39025884 |
| exon_skip_230976 | chr8 | 38997026:38997160:39007886:39007983:39011658:39011716 | 39007886:39007983 |
| exon_skip_265790 | chr8 | 39055577:39055772:39071298:39071403:39077228:39077411 | 39071298:39071403 |
| exon_skip_284049 | chr8 | 39026677:39026810:39041946:39042117:39054481:39054517 | 39041946:39042117 |
| exon_skip_57125 | chr8 | 39007886:39007983:39011658:39011716:39013965:39014043 | 39011658:39011716 |
| exon_skip_68861 | chr8 | 39055577:39055772:39071298:39071403:39077228:39077301 | 39071298:39071403 |
| exon_skip_77010 | chr8 | 39026677:39026810:39041946:39042117:39054481:39054573 | 39041946:39042117 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for ADAM9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
Top |
Infer the effects of exon skipping event on protein functional features for ADAM9 |
p-ENSG00000168615_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in ADAM9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for ADAM9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for ADAM9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADAM9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for ADAM9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for ADAM9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ADAM9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|