ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for ADAM15

Gene summary

Gene information	Gene symbol	ADAM15
	Gene ID	8751
	Gene name	ADAM metallopeptidase domain 15
	Synonyms	MDC15
	Cytomap	1q21.3
	Type of gene	protein-coding
	Description	disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
	Modification date	20200320
	UniProtAcc	Q13444,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ADAM15	GO:0002418	immune response to tumor cell	22505472
ADAM15	GO:0006915	apoptotic process	22505472
ADAM15	GO:0045087	innate immune response	22505472
ADAM15	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	22505472

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Gene structures and expression levels for ADAM15

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000143537

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	DOWN	ENST00000464824.2	ADAM15-213:retained_intron:ADAM15	2.366826e+02	-1.109643e+00	6.550158e-11	4.429017e-09
CB	DOWN	ENST00000461234.5	ADAM15-210:lncRNA:ADAM15	6.394567e+01	-1.089028e+00	2.641632e-07	4.826581e-06
CB	UP	ENST00000477533.5	ADAM15-219:lncRNA:ADAM15	1.211629e+01	8.644305e-01	4.805944e-06	5.659691e-05
CB	DOWN	ENST00000462116.5	ADAM15-212:lncRNA:ADAM15	5.802450e+00	-9.186590e-01	7.057782e-04	3.853430e-03
CB	DOWN	ENST00000449910.6	ADAM15-209:protein_coding:ADAM15	1.130768e+02	-1.032577e+00	1.201017e-02	4.034266e-02
CB	DOWN	ENST00000356955.6	ADAM15-203:protein_coding:ADAM15	1.608089e+00	-4.206948e+00	1.307603e-02	4.320064e-02
TC	DOWN	ENST00000464824.2	ADAM15-213:retained_intron:ADAM15	1.137028e+02	-1.027362e+00	7.401348e-09	6.987031e-07
TC	DOWN	ENST00000461234.5	ADAM15-210:lncRNA:ADAM15	3.413431e+01	-1.746192e+00	1.226671e-06	4.721208e-05

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ADAM15

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_105275	chr1	155061453:155061489:155061904:155061975:155062245:155062369	155061904:155061975
exon_skip_108627	chr1	155054316:155054506:155055702:155055852:155055932:155056000	155055702:155055852
exon_skip_113041	chr1	155054316:155054506:155055790:155055852:155055932:155056000	155055790:155055852
exon_skip_11575	chr1	155055932:155056000:155056080:155056249:155056386:155056407	155056080:155056249
exon_skip_118621	chr1	155060763:155060832:155061904:155062117:155062245:155062369	155061904:155062117
exon_skip_121296	chr1	155060768:155060832:155061904:155061975:155062245:155062369	155061904:155061975
exon_skip_12801	chr1	155061453:155061489:155061576:155061646:155062245:155062369	155061576:155061646
exon_skip_14276	chr1	155051354:155051465:155052531:155052559:155052671:155052777	155052531:155052559
exon_skip_145564	chr1	155060266:155060343:155060763:155060832:155061114:155061193	155060763:155060832
exon_skip_15140	chr1	155060763:155060832:155061415:155061489:155061904:155061975	155061415:155061489
exon_skip_153108	chr1	155060266:155060343:155060763:155060832:155062245:155062369	155060763:155060832
exon_skip_164378	chr1	155060205:155060343:155060763:155060832:155061418:155061489	155060763:155060832
exon_skip_167067	chr1	155061453:155061489:155061904:155062117:155062245:155062369	155061904:155062117
exon_skip_168213	chr1	155060763:155060832:155062245:155062369:155062460:155062669	155062245:155062369
exon_skip_171045	chr1	155061904:155061975:155062245:155062369:155062460:155062669	155062245:155062369
exon_skip_178550	chr1	155060266:155060343:155060763:155060832:155061415:155061446	155060763:155060832
exon_skip_183974	chr1	155060763:155060832:155061904:155061975:155062245:155062369	155061904:155061975
exon_skip_199787	chr1	155060768:155060832:155061415:155061489:155061904:155061975	155061415:155061489
exon_skip_201477	chr1	155060205:155060343:155061418:155061489:155062245:155062369	155061418:155061489
exon_skip_20163	chr1	155060763:155060832:155061415:155061489:155062245:155062369	155061415:155061489
exon_skip_215136	chr1	155061904:155061975:155062245:155062369:155062460:155062492	155062245:155062369
exon_skip_217420	chr1	155059902:155059974:155060205:155060343:155060763:155060832	155060205:155060343
exon_skip_229231	chr1	155052671:155052777:155053417:155053493:155053910:155053923	155053417:155053493
exon_skip_233686	chr1	155060763:155060832:155061415:155061489:155061904:155061960	155061415:155061489
exon_skip_235868	chr1	155060266:155060343:155060763:155060832:155061418:155061489	155060763:155060832
exon_skip_239657	chr1	155055956:155056000:155056080:155056249:155056386:155056407	155056080:155056249
exon_skip_245420	chr1	155060768:155060832:155061114:155061193:155061415:155061446	155061114:155061193
exon_skip_247202	chr1	155060768:155060832:155061418:155061489:155061904:155061975	155061418:155061489
exon_skip_250153	chr1	155060763:155060832:155061418:155061489:155061904:155061975	155061418:155061489
exon_skip_251185	chr1	155061418:155061489:155061904:155062117:155062245:155062369	155061904:155062117
exon_skip_254074	chr1	155060768:155060832:155061904:155062117:155062245:155062369	155061904:155062117
exon_skip_260935	chr1	155054314:155054506:155055790:155055852:155055932:155056000	155055790:155055852
exon_skip_264981	chr1	155061418:155061489:155061904:155061975:155062245:155062369	155061904:155061975
exon_skip_26673	chr1	155053417:155053493:155053910:155053988:155054150:155054226	155053910:155053988
exon_skip_26928	chr1	155060266:155060343:155061418:155061489:155062245:155062369	155061418:155061489
exon_skip_276995	chr1	155061904:155062117:155062245:155062369:155062460:155062669	155062245:155062369
exon_skip_29662	chr1	155058246:155058441:155058710:155058787:155059902:155059974	155058710:155058787
exon_skip_42879	chr1	155061418:155061489:155061576:155061646:155062245:155062369	155061576:155061646
exon_skip_44324	chr1	155060763:155060832:155061418:155061489:155061904:155061960	155061418:155061489
exon_skip_49455	chr1	155060266:155060343:155060763:155060832:155061904:155061975	155060763:155060832
exon_skip_51352	chr1	155060763:155060832:155061114:155061193:155061415:155061446	155061114:155061193
exon_skip_56473	chr1	155051352:155051465:155052531:155052559:155052671:155052777	155052531:155052559
exon_skip_90017	chr1	155054314:155054506:155055702:155055852:155055932:155056000	155055702:155055852
exon_skip_90845	chr1	155053910:155053988:155054150:155054226:155054314:155054506	155054150:155054226
exon_skip_9422	chr1	155054314:155054506:155055787:155055852:155055932:155056000	155055787:155055852
exon_skip_98150	chr1	155060768:155060832:155061415:155061489:155062245:155062369	155061415:155061489
exon_skip_998	chr1	155054316:155054506:155055787:155055852:155055932:155056000	155055787:155055852

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_153108	Mayo_CB	7.941463e-01	9.018667e-01	-1.077203e-01	2.051934e-02
exon_skip_98150	Mayo_CB	2.840741e-01	4.122368e-01	-1.281628e-01	5.866377e-07
exon_skip_81158	Mayo_CB	2.832099e-01	4.128947e-01	-1.296849e-01	4.793656e-07
exon_skip_167067	Mayo_CB	6.034568e-01	4.314286e-01	1.720282e-01	3.338593e-07
exon_skip_162761	Mayo_CB	7.077941e-01	6.046032e-01	1.031909e-01	6.052063e-03
exon_skip_98150	Mayo_TC	4.224691e-01	5.526923e-01	-1.302232e-01	3.040463e-05
exon_skip_81158	Mayo_TC	4.328395e-01	5.665385e-01	-1.336990e-01	3.197243e-05
exon_skip_167067	Mayo_TC	3.472500e-01	2.409091e-01	1.063409e-01	4.796410e-03

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Open reading frame (ORF) annotation in the exon skipping event for ADAM15

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000356955	155053417	155053493	Frame-shift
ENST00000356955	155053910	155053988	Frame-shift
ENST00000356955	155054150	155054226	Frame-shift
ENST00000356955	155056080	155056249	Frame-shift
ENST00000356955	155060763	155060832	Frame-shift
ENST00000356955	155062245	155062369	Frame-shift
ENST00000356955	155055790	155055852	In-frame
ENST00000356955	155058710	155058787	In-frame
ENST00000356955	155061415	155061489	In-frame
ENST00000356955	155061904	155061975	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000356955	155053417	155053493	Frame-shift
ENST00000356955	155055790	155055852	In-frame
ENST00000356955	155061415	155061489	In-frame
ENST00000356955	155061904	155061975	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000356955	155053417	155053493	Frame-shift
ENST00000356955	155054150	155054226	Frame-shift
ENST00000356955	155056080	155056249	Frame-shift
ENST00000356955	155060205	155060343	Frame-shift
ENST00000356955	155060763	155060832	Frame-shift
ENST00000356955	155062245	155062369	Frame-shift
ENST00000356955	155055790	155055852	In-frame
ENST00000356955	155058710	155058787	In-frame
ENST00000356955	155061415	155061489	In-frame
ENST00000356955	155061904	155061975	In-frame

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Infer the effects of exon skipping event on protein functional features for ADAM15

p-ENSG00000143537_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000356955	2966	863	155055790	155055852	715	776	204	225
ENST00000356955	2966	863	155058710	155058787	2020	2096	639	665
ENST00000356955	2966	863	155061415	155061489	2380	2453	759	784
ENST00000356955	2966	863	155061904	155061975	2455	2525	784	808

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000356955	2966	863	155055790	155055852	715	776	204	225
ENST00000356955	2966	863	155061415	155061489	2380	2453	759	784
ENST00000356955	2966	863	155061904	155061975	2455	2525	784	808

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000356955	2966	863	155055790	155055852	715	776	204	225
ENST00000356955	2966	863	155058710	155058787	2020	2096	639	665
ENST00000356955	2966	863	155061415	155061489	2380	2453	759	784
ENST00000356955	2966	863	155061904	155061975	2455	2525	784	808

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13444	204	225	94	387	Alternative sequence	ID=VSP_039524;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:16303743;Dbxref=PMID:16303743
Q13444	204	225	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	204	225	213	414	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00276
Q13444	204	225	216	216	Natural variant	ID=VAR_068970;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs115753757,PMID:14702039
Q13444	204	225	18	206	Propeptide	ID=PRO_0000029082;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	204	225	207	696	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	639	665	641	649	Alternative sequence	ID=VSP_055144;Note=In isoform 13. CIDHRCQRV->SSLGGQDQV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	639	665	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	639	665	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	639	665	509	656	Compositional bias	Note=Cys-rich
Q13444	639	665	657	667	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	639	665	661	673	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	639	665	657	685	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00076
Q13444	639	665	649	649	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q13444	639	665	207	696	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	759	784	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	759	784	736	772	Alternative sequence	ID=VSP_039525;Note=In isoform 10. RAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSR->SLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID
Q13444	759	784	737	796	Alternative sequence	ID=VSP_039526;Note=In isoform 9. AAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTR->LVLSASRPPLPGRCRLTLCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	760	808	Alternative sequence	ID=VSP_039527;Note=In isoform 2%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:000030
Q13444	759	784	760	784	Alternative sequence	ID=VSP_039528;Note=In isoform 5 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	760	760	Alternative sequence	ID=VSP_039529;Note=In isoform 3 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	773	863	Alternative sequence	ID=VSP_039530;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:15358598,PMID:18296648
Q13444	759	784	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	759	784	718	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	784	808	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	784	808	737	796	Alternative sequence	ID=VSP_039526;Note=In isoform 9. AAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTR->LVLSASRPPLPGRCRLTLCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	760	808	Alternative sequence	ID=VSP_039527;Note=In isoform 2%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:000030
Q13444	784	808	760	784	Alternative sequence	ID=VSP_039528;Note=In isoform 5 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	773	863	Alternative sequence	ID=VSP_039530;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:15358598,PMID:18296648
Q13444	784	808	785	808	Alternative sequence	ID=VSP_039531;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:18296648
Q13444	784	808	797	863	Alternative sequence	ID=VSP_039532;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	784	808	718	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13444	204	225	94	387	Alternative sequence	ID=VSP_039524;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:16303743;Dbxref=PMID:16303743
Q13444	204	225	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	204	225	213	414	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00276
Q13444	204	225	216	216	Natural variant	ID=VAR_068970;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs115753757,PMID:14702039
Q13444	204	225	18	206	Propeptide	ID=PRO_0000029082;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	204	225	207	696	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	759	784	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	759	784	736	772	Alternative sequence	ID=VSP_039525;Note=In isoform 10. RAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSR->SLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID
Q13444	759	784	737	796	Alternative sequence	ID=VSP_039526;Note=In isoform 9. AAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTR->LVLSASRPPLPGRCRLTLCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	760	808	Alternative sequence	ID=VSP_039527;Note=In isoform 2%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:000030
Q13444	759	784	760	784	Alternative sequence	ID=VSP_039528;Note=In isoform 5 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	760	760	Alternative sequence	ID=VSP_039529;Note=In isoform 3 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	773	863	Alternative sequence	ID=VSP_039530;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:15358598,PMID:18296648
Q13444	759	784	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	759	784	718	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	784	808	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	784	808	737	796	Alternative sequence	ID=VSP_039526;Note=In isoform 9. AAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTR->LVLSASRPPLPGRCRLTLCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	760	808	Alternative sequence	ID=VSP_039527;Note=In isoform 2%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:000030
Q13444	784	808	760	784	Alternative sequence	ID=VSP_039528;Note=In isoform 5 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	773	863	Alternative sequence	ID=VSP_039530;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:15358598,PMID:18296648
Q13444	784	808	785	808	Alternative sequence	ID=VSP_039531;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:18296648
Q13444	784	808	797	863	Alternative sequence	ID=VSP_039532;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	784	808	718	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q13444	204	225	94	387	Alternative sequence	ID=VSP_039524;Note=In isoform 11. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:16303743;Dbxref=PMID:16303743
Q13444	204	225	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	204	225	213	414	Domain	Note=Peptidase M12B;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00276
Q13444	204	225	216	216	Natural variant	ID=VAR_068970;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs115753757,PMID:14702039
Q13444	204	225	18	206	Propeptide	ID=PRO_0000029082;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	204	225	207	696	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	639	665	641	649	Alternative sequence	ID=VSP_055144;Note=In isoform 13. CIDHRCQRV->SSLGGQDQV;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	639	665	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	639	665	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	639	665	509	656	Compositional bias	Note=Cys-rich
Q13444	639	665	657	667	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	639	665	661	673	Disulfide bond	Ontology_term=ECO:0000250;evidence=ECO:0000250
Q13444	639	665	657	685	Domain	Note=EGF-like;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00076
Q13444	639	665	649	649	Sequence conflict	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q13444	639	665	207	696	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	759	784	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	759	784	736	772	Alternative sequence	ID=VSP_039525;Note=In isoform 10. RAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSR->SLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID
Q13444	759	784	737	796	Alternative sequence	ID=VSP_039526;Note=In isoform 9. AAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTR->LVLSASRPPLPGRCRLTLCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	760	808	Alternative sequence	ID=VSP_039527;Note=In isoform 2%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:000030
Q13444	759	784	760	784	Alternative sequence	ID=VSP_039528;Note=In isoform 5 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	760	760	Alternative sequence	ID=VSP_039529;Note=In isoform 3 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	759	784	773	863	Alternative sequence	ID=VSP_039530;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:15358598,PMID:18296648
Q13444	759	784	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	759	784	718	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q13444	784	808	650	863	Alternative sequence	ID=VSP_055145;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q13444	784	808	737	796	Alternative sequence	ID=VSP_039526;Note=In isoform 9. AAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQAELADRPNPPTR->LVLSASRPPLPGRCRLTLCPRDSSLRGQPSPHPQGSHCLPTPRAGAHRVTCPAQGLESRP;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	760	808	Alternative sequence	ID=VSP_039527;Note=In isoform 2%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:14702039,ECO:0000303\|PubMed:15489334,ECO:000030
Q13444	784	808	760	784	Alternative sequence	ID=VSP_039528;Note=In isoform 5 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	773	863	Alternative sequence	ID=VSP_039530;Note=In isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:15358598,ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:15358598,PMID:18296648
Q13444	784	808	785	808	Alternative sequence	ID=VSP_039531;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:18296648,ECO:0000303\|Ref.6;Dbxref=PMID:18296648
Q13444	784	808	797	863	Alternative sequence	ID=VSP_039532;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q13444	784	808	207	863	Chain	ID=PRO_0000029083;Note=Disintegrin and metalloproteinase domain-containing protein 15
Q13444	784	808	718	863	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

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3'-UTR located exon skipping events that lost miRNA binding sites in ADAM15

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for ADAM15

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for ADAM15

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ADAM15

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_153108	rs1001848	chr1:155074903	1.324672e-05	3.309413e-03
CB	exon_skip_178550	rs1001848	chr1:155074903	5.520584e-05	1.074209e-02
CB	exon_skip_153108	rs10908455	chr1:155094807	2.593650e-04	3.645832e-02
CB	exon_skip_153108	rs4745	chr1:155133751	3.595772e-04	4.670754e-02
TC	exon_skip_153108	rs1001848	chr1:155074903	2.560771e-05	5.383124e-03
HCC	exon_skip_153108	rs7368345	chr1:155107614	1.118039e-07	2.211332e-05
HCC	exon_skip_153108	rs6693477	chr1:155109464	1.118039e-07	2.211332e-05
HCC	exon_skip_153108	rs4971079	chr1:155157915	2.583559e-06	3.847531e-04
HCC	exon_skip_153108	rs10908456	chr1:155113672	8.229485e-05	7.758731e-03
HCC	exon_skip_153108	rs10908454	chr1:155093940	1.144315e-04	1.026293e-02
HCC	exon_skip_153108	rs1001848	chr1:155074903	1.385153e-04	1.201152e-02
HCC	exon_skip_153108	rs10908449	chr1:154983248	1.913890e-04	1.562712e-02
HCC	exon_skip_153108	rs6696397	chr1:154984186	1.913890e-04	1.562712e-02
HCC	exon_skip_153108	rs10908455	chr1:155094807	2.119509e-04	1.699992e-02
HCC	exon_skip_153108	rs2242193	chr1:155023027	3.704116e-04	2.674956e-02
HCC	exon_skip_153108	rs16836580	chr1:154972571	7.134749e-04	4.489724e-02
PCC	exon_skip_153108	rs7368345	chr1:155107614	3.569270e-04	4.676387e-02
PCC	exon_skip_153108	rs6693477	chr1:155109464	3.569270e-04	4.676387e-02
DLPFC	exon_skip_153108	rs7368345	chr1:155107614	2.267834e-09	5.873268e-07
DLPFC	exon_skip_153108	rs6693477	chr1:155109464	2.267834e-09	5.873268e-07
DLPFC	exon_skip_153108	rs4971079	chr1:155157915	1.773895e-07	3.100086e-05
DLPFC	exon_skip_153108	rs10908456	chr1:155113672	1.080604e-06	1.575107e-04
DLPFC	exon_skip_153108	rs1001848	chr1:155074903	1.321079e-06	1.882909e-04
DLPFC	exon_skip_153108	rs10908454	chr1:155093940	7.453738e-06	8.652943e-04
DLPFC	exon_skip_153108	rs10908455	chr1:155094807	1.593013e-05	1.697077e-03
DLPFC	exon_skip_153108	rs10157801	chr1:155147536	2.407593e-05	2.444811e-03
DLPFC	exon_skip_153108	rs4276913	chr1:155159197	5.244695e-05	4.832264e-03
DLPFC	exon_skip_153108	rs2242193	chr1:155023027	1.076823e-04	9.007298e-03
DLPFC	exon_skip_178550	rs7368345	chr1:155107614	2.606785e-04	1.923345e-02
DLPFC	exon_skip_178550	rs6693477	chr1:155109464	2.606785e-04	1.923345e-02
DLPFC	exon_skip_251185	rs12023499	chr1:155058900	6.510889e-04	3.983877e-02

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Correlation with RNA binding proteins (RBPs) for ADAM15

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	DAZAP1	exon_skip_229231	-4.701538e-01	4.033194e-10
CB	SAMD4A	exon_skip_229231	-4.614352e-01	9.268084e-10
CB	HNRNPA2B1	exon_skip_229231	-4.374552e-01	8.128021e-09
CB	RBM6	exon_skip_98150	-4.313753e-01	1.697252e-08
CB	CNOT4	exon_skip_98150	-4.630605e-01	1.018286e-09
CB	PCBP4	exon_skip_98150	4.536444e-01	2.421669e-09
CB	RBM23	exon_skip_98150	-4.049692e-01	1.433892e-07
CB	RBM6	exon_skip_81158	-4.232045e-01	3.350104e-08
CB	CNOT4	exon_skip_81158	-4.693547e-01	5.622458e-10
CB	PCBP4	exon_skip_81158	4.597740e-01	1.381937e-09
CB	RBM23	exon_skip_81158	-4.096980e-01	9.916438e-08
CB	RBM6	exon_skip_167067	4.410879e-01	6.608224e-09
CB	RBM23	exon_skip_167067	4.499970e-01	2.994688e-09
DLPFC	NOVA1	exon_skip_42879	4.769043e-01	3.327830e-15
TC	PCBP4	exon_skip_98150	4.628147e-01	8.137519e-10
TC	PCBP4	exon_skip_81158	4.690850e-01	4.471913e-10
TC	NOVA1	exon_skip_28933	4.431381e-01	1.083385e-08

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RelatedDrugs for ADAM15

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ADAM15

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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