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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NOL4 |
 Gene summary |
| Gene information | Gene symbol | NOL4 | Gene ID | 8715 |
| Gene name | nucleolar protein 4 | |
| Synonyms | CT125|HRIHFB2255|NOLP | |
| Cytomap | 18q12.1 | |
| Type of gene | protein-coding | |
| Description | nucleolar protein 4cancer/testis antigen 125nucleolar localized protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NOL4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000101746
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000590712.5 | NOL4-212:protein_coding:NOL4 | 5.394779e+01 | 1.168348e+00 | 7.238170e-03 | 2.666700e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NOL4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100655 | chr18 | 34105125:34105160:34121234:34121316:34129871:34130020 | 34121234:34121316 |
| exon_skip_116475 | chr18 | 33883365:33883424:33943065:33943178:33958239:33958418 | 33943065:33943178 |
| exon_skip_126021 | chr18 | 34104054:34104159:34105049:34105160:34129871:34130020 | 34105049:34105160 |
| exon_skip_238809 | chr18 | 33943065:33943178:33957326:33957517:33958239:33958418 | 33957326:33957517 |
| exon_skip_239282 | chr18 | 34105125:34105160:34128849:34128889:34129871:34130020 | 34128849:34128889 |
| exon_skip_253365 | chr18 | 33852589:33853035:33883244:33883424:33943065:33943178 | 33883244:33883424 |
| exon_skip_283996 | chr18 | 34105049:34105160:34121234:34121316:34129871:34130020 | 34121234:34121316 |
| exon_skip_6563 | chr18 | 33883365:33883424:33943065:33943178:33957326:33957517 | 33943065:33943178 |
| exon_skip_74612 | chr18 | 34104134:34104159:34105049:34105160:34129871:34130020 | 34105049:34105160 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_238809 | Mayo_TC | 3.329870e-01 | 4.466667e-01 | -1.136797e-01 | 1.029965e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for NOL4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261592 | 33883244 | 33883424 | Frame-shift |
| ENST00000261592 | 34105049 | 34105160 | Frame-shift |
| ENST00000261592 | 33957326 | 33957517 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261592 | 33957326 | 33957517 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000261592 | 33883244 | 33883424 | Frame-shift |
| ENST00000261592 | 34105049 | 34105160 | Frame-shift |
| ENST00000261592 | 33943065 | 33943178 | In-frame |
| ENST00000261592 | 33957326 | 33957517 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NOL4 |
p-ENSG00000101746_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261592 | 3974 | 638 | 33957326 | 33957517 | 1535 | 1725 | 412 | 475 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261592 | 3974 | 638 | 33957326 | 33957517 | 1535 | 1725 | 412 | 475 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000261592 | 3974 | 638 | 33957326 | 33957517 | 1535 | 1725 | 412 | 475 |
| ENST00000261592 | 3974 | 638 | 33943065 | 33943178 | 1727 | 1839 | 476 | 513 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94818 | 412 | 475 | 413 | 514 | Alternative sequence | ID=VSP_010080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:15489334 |
| O94818 | 412 | 475 | 1 | 638 | Chain | ID=PRO_0000096935;Note=Nucleolar protein 4 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94818 | 412 | 475 | 413 | 514 | Alternative sequence | ID=VSP_010080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:15489334 |
| O94818 | 412 | 475 | 1 | 638 | Chain | ID=PRO_0000096935;Note=Nucleolar protein 4 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94818 | 412 | 475 | 413 | 514 | Alternative sequence | ID=VSP_010080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:15489334 |
| O94818 | 412 | 475 | 1 | 638 | Chain | ID=PRO_0000096935;Note=Nucleolar protein 4 |
| O94818 | 476 | 513 | 413 | 514 | Alternative sequence | ID=VSP_010080;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5,ECO:0000303|Ref.6;Dbxref=PMID:15489334 |
| O94818 | 476 | 513 | 1 | 638 | Chain | ID=PRO_0000096935;Note=Nucleolar protein 4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in NOL4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for NOL4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NOL4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NOL4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NOL4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM3 | exon_skip_238809 | 4.122677e-01 | 1.925632e-07 |
| CB | NUP42 | exon_skip_238809 | 4.545629e-01 | 6.495854e-09 |
| CB | RBM4 | exon_skip_238809 | -4.190831e-01 | 1.150222e-07 |
| IFG | PABPC5 | exon_skip_238809 | -4.553214e-01 | 2.536571e-02 |
| TC | SRSF2 | exon_skip_238809 | 4.151507e-01 | 6.111110e-07 |
| TC | MSI1 | exon_skip_238809 | -4.731243e-01 | 7.794633e-09 |
| TC | ELAVL4 | exon_skip_238809 | 6.946900e-01 | 1.283807e-20 |
| TC | NUP42 | exon_skip_238809 | 5.227766e-01 | 9.202458e-11 |
| TC | RALYL | exon_skip_238809 | 6.503668e-01 | 1.828543e-17 |
| TC | CELF1 | exon_skip_238809 | 4.033468e-01 | 1.350069e-06 |
| TC | RBM24 | exon_skip_239282 | -4.735016e-01 | 2.148696e-08 |
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RelatedDrugs for NOL4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOL4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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