ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for EIF4G3

Gene summary

Gene information	Gene symbol	EIF4G3
	Gene ID	8672
	Gene name	eukaryotic translation initiation factor 4 gamma 3
	Synonyms	eIF-4G 3\|eIF4G 3\|eIF4GII
	Cytomap	1p36.12
	Type of gene	protein-coding
	Description	eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II
	Modification date	20200313
	UniProtAcc	A0A0A0MSA7, A0A0U1RQK7, B1AN91, B1AN92, O43432,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

Gene structures and expression levels for EIF4G3

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000075151

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000634879.1	EIF4G3-214:protein_coding:EIF4G3	5.138082e+01	8.915121e+00	2.737528e-08	2.770818e-05
STG	UP	ENST00000356916.7	EIF4G3-202:protein_coding:EIF4G3	2.366030e+01	2.056415e+00	3.278979e-08	3.200322e-05
STG	UP	ENST00000411888.5	EIF4G3-206:protein_coding:EIF4G3	1.138822e+01	8.949672e-01	1.962444e-04	1.641745e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EIF4G3

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_125605	chr1	20860385:20860517:20862228:20862332:20864476:20864712	20862228:20862332
exon_skip_143068	chr1	20817392:20817538:20825100:20825198:20827617:20827698	20825100:20825198
exon_skip_146723	chr1	20941491:20942330:20950003:20950111:20969474:20969596	20950003:20950111
exon_skip_147149	chr1	20886201:20886371:20892619:20892729:20893517:20893636	20892619:20892729
exon_skip_154850	chr1	20886316:20886371:20892619:20892729:20893517:20893636	20892619:20892729
exon_skip_165518	chr1	20941731:20942330:20950003:20950108:20969474:20969596	20950003:20950108
exon_skip_171610	chr1	20840856:20841028:20849415:20849530:20851258:20851478	20849415:20849530
exon_skip_174466	chr1	20817398:20817538:20825100:20825198:20827617:20827698	20825100:20825198
exon_skip_182765	chr1	21002713:21002808:21050866:21050994:21089138:21089213	21050866:21050994
exon_skip_191858	chr1	20904883:20904971:20950003:20950111:20969474:20969596	20950003:20950111
exon_skip_193974	chr1	20941491:20942330:20950003:20950108:20969474:20969596	20950003:20950108
exon_skip_195469	chr1	20807319:20807500:20810738:20810884:20813158:20813239	20810738:20810884
exon_skip_197043	chr1	20981048:20981227:20982388:20982408:21002713:21002808	20982388:20982408
exon_skip_208431	chr1	21002713:21002808:21050866:21050994:21089138:21089204	21050866:21050994
exon_skip_21444	chr1	20969474:20969596:20973002:20973099:20980334:20980448	20973002:20973099
exon_skip_230434	chr1	20840856:20841028:20849415:20849530:20851258:20851425	20849415:20849530
exon_skip_240557	chr1	20825104:20825198:20827617:20827698:20829147:20829272	20827617:20827698
exon_skip_260997	chr1	20851258:20851478:20853560:20853677:20854978:20855071	20853560:20853677
exon_skip_262668	chr1	20879323:20879520:20886201:20886371:20893517:20893636	20886201:20886371
exon_skip_285406	chr1	20942218:20942330:20950003:20950111:20969474:20969596	20950003:20950111
exon_skip_287552	chr1	20895368:20895501:20899697:20899943:20904883:20904971	20899697:20899943
exon_skip_288944	chr1	20941731:20942330:20950003:20950111:20969474:20969596	20950003:20950111
exon_skip_34828	chr1	20807425:20807500:20810738:20810884:20813158:20813239	20810738:20810884
exon_skip_43680	chr1	20829147:20829272:20840856:20841028:20849415:20849530	20840856:20841028
exon_skip_58874	chr1	20981048:20981227:21001199:21001312:21002713:21002808	21001199:21001312
exon_skip_68208	chr1	20904883:20904971:20941491:20942330:20950003:20950108	20941491:20942330
exon_skip_83929	chr1	20942218:20942330:20950003:20950108:20969474:20969596	20950003:20950108
exon_skip_90324	chr1	20981048:20981227:20997601:20997633:21002713:21002808	20997601:20997633

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_197043	Mayo_TC	4.118750e-01	5.148485e-01	-1.029735e-01	2.268214e-04

Top

Open reading frame (ORF) annotation in the exon skipping event for EIF4G3

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000264211	20827617	20827698	Frame-shift
ENST00000264211	20840856	20841028	Frame-shift
ENST00000264211	20849415	20849530	Frame-shift
ENST00000264211	20950003	20950111	Frame-shift
ENST00000264211	20973002	20973099	Frame-shift
ENST00000264211	20810738	20810884	In-frame
ENST00000264211	20825100	20825198	In-frame
ENST00000264211	20862228	20862332	In-frame
ENST00000264211	20886201	20886371	In-frame
ENST00000264211	20941491	20942330	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000264211	20899697	20899943	Frame-shift
ENST00000264211	20950003	20950111	Frame-shift
ENST00000264211	20810738	20810884	In-frame
ENST00000264211	20886201	20886371	In-frame
ENST00000264211	20941491	20942330	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000264211	20827617	20827698	Frame-shift
ENST00000264211	20840856	20841028	Frame-shift
ENST00000264211	20849415	20849530	Frame-shift
ENST00000264211	20853560	20853677	Frame-shift
ENST00000264211	20899697	20899943	Frame-shift
ENST00000264211	20950003	20950111	Frame-shift
ENST00000264211	20810738	20810884	In-frame
ENST00000264211	20825100	20825198	In-frame
ENST00000264211	20862228	20862332	In-frame
ENST00000264211	20886201	20886371	In-frame
ENST00000264211	20941491	20942330	In-frame

Top

Infer the effects of exon skipping event on protein functional features for EIF4G3

p-ENSG00000075151_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000264211	5819	1585	20941491	20942330	851	1689	218	498
ENST00000264211	5819	1585	20886201	20886371	2281	2450	695	751
ENST00000264211	5819	1585	20862228	20862332	3034	3137	946	980
ENST00000264211	5819	1585	20825100	20825198	4297	4394	1367	1399
ENST00000264211	5819	1585	20810738	20810884	4625	4770	1476	1525

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000264211	5819	1585	20941491	20942330	851	1689	218	498
ENST00000264211	5819	1585	20886201	20886371	2281	2450	695	751
ENST00000264211	5819	1585	20810738	20810884	4625	4770	1476	1525

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000264211	5819	1585	20941491	20942330	851	1689	218	498
ENST00000264211	5819	1585	20886201	20886371	2281	2450	695	751
ENST00000264211	5819	1585	20862228	20862332	3034	3137	946	980
ENST00000264211	5819	1585	20825100	20825198	4297	4394	1367	1399
ENST00000264211	5819	1585	20810738	20810884	4625	4770	1476	1525

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O43432	218	498	219	498	Alternative sequence	ID=VSP_054502;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	218	498	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	218	498	447	475	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O43432	218	498	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
O43432	218	498	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID
O43432	218	498	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
O43432	218	498	441	441	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q80XI3
O43432	218	498	495	495	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17693683,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:18
O43432	218	498	378	378	Natural variant	ID=VAR_048924;Note=Q->R;Dbxref=dbSNP:rs35731992
O43432	218	498	496	496	Natural variant	ID=VAR_034009;Note=P->A;Dbxref=dbSNP:rs35176330
O43432	218	498	333	333	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O43432	695	751	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	695	751	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	695	751	746	762	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	695	751	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
O43432	695	751	745	783	Repeat	Note=HEAT 1
O43432	695	751	699	700	Site	Note=Cleavage%3B by enterovirus/rhinovirus protease 2A
O43432	695	751	700	701	Site	Note=Cleavage%3B by foot-and-mouth disease virus leader protease
O43432	946	980	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	946	980	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	946	980	755	983	Domain	Note=MIF4G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
O43432	946	980	946	961	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	946	980	967	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	946	980	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
O43432	946	980	945	984	Repeat	Note=HEAT 5
O43432	1367	1399	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	1367	1399	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	1476	1525	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	1476	1525	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	1476	1525	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00695
O43432	1476	1525	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O43432	218	498	219	498	Alternative sequence	ID=VSP_054502;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	218	498	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	218	498	447	475	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O43432	218	498	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
O43432	218	498	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID
O43432	218	498	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
O43432	218	498	441	441	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q80XI3
O43432	218	498	495	495	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17693683,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:18
O43432	218	498	378	378	Natural variant	ID=VAR_048924;Note=Q->R;Dbxref=dbSNP:rs35731992
O43432	218	498	496	496	Natural variant	ID=VAR_034009;Note=P->A;Dbxref=dbSNP:rs35176330
O43432	218	498	333	333	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O43432	695	751	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	695	751	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	695	751	746	762	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	695	751	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
O43432	695	751	745	783	Repeat	Note=HEAT 1
O43432	695	751	699	700	Site	Note=Cleavage%3B by enterovirus/rhinovirus protease 2A
O43432	695	751	700	701	Site	Note=Cleavage%3B by foot-and-mouth disease virus leader protease
O43432	1476	1525	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	1476	1525	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	1476	1525	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00695
O43432	1476	1525	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O43432	218	498	219	498	Alternative sequence	ID=VSP_054502;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	218	498	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	218	498	447	475	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O43432	218	498	230	230	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163
O43432	218	498	232	232	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,ECO:0000244\|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163,PMID
O43432	218	498	267	267	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:24275569;Dbxref=PMID:24275569
O43432	218	498	441	441	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q80XI3
O43432	218	498	495	495	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:17693683,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:18
O43432	218	498	378	378	Natural variant	ID=VAR_048924;Note=Q->R;Dbxref=dbSNP:rs35731992
O43432	218	498	496	496	Natural variant	ID=VAR_034009;Note=P->A;Dbxref=dbSNP:rs35176330
O43432	218	498	333	333	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O43432	695	751	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	695	751	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	695	751	746	762	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	695	751	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
O43432	695	751	745	783	Repeat	Note=HEAT 1
O43432	695	751	699	700	Site	Note=Cleavage%3B by enterovirus/rhinovirus protease 2A
O43432	695	751	700	701	Site	Note=Cleavage%3B by foot-and-mouth disease virus leader protease
O43432	946	980	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	946	980	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	946	980	755	983	Domain	Note=MIF4G;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
O43432	946	980	946	961	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	946	980	967	981	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1HU3
O43432	946	980	699	1019	Region	Note=eIF3/EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250
O43432	946	980	945	984	Repeat	Note=HEAT 5
O43432	1367	1399	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	1367	1399	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	1476	1525	505	1585	Alternative sequence	ID=VSP_010489;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
O43432	1476	1525	1	1585	Chain	ID=PRO_0000213329;Note=Eukaryotic translation initiation factor 4 gamma 3
O43432	1476	1525	1416	1585	Domain	Note=W2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00695
O43432	1476	1525	1433	1585	Region	Note=EIF4A-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250

Top

3'-UTR located exon skipping events that lost miRNA binding sites in EIF4G3

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for EIF4G3

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for EIF4G3

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

ROSMAP

HCC

exon_skip_154850

-3.520114e-01

2.200000e-09

chr1

20886316

20886371

20892619

20892729

20893517

20893636

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EIF4G3

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for EIF4G3

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	DAZAP1	exon_skip_195469	-4.315404e-01	1.353823e-08
CB	TARDBP	exon_skip_195469	-4.195457e-01	3.698854e-08
CB	CNOT4	exon_skip_195469	-4.900937e-01	5.495769e-11
CB	NUP42	exon_skip_147149	4.938614e-01	6.581702e-11
CB	RBM6	exon_skip_83929	-4.114804e-01	1.855373e-07
CB	RBM6	exon_skip_285406	-4.068432e-01	3.161382e-07
CB	PCBP4	exon_skip_285406	4.145012e-01	1.795211e-07
CB	U2AF2	exon_skip_200677	-4.227745e-01	9.034101e-07
IFG	LIN28A	exon_skip_197043	4.116263e-01	2.953025e-02
IFG	ELAVL4	exon_skip_200677	-4.730170e-01	1.270895e-02
IFG	SAMD4A	exon_skip_200677	4.840194e-01	1.052293e-02
IFG	TIA1	exon_skip_200677	4.751574e-01	1.225648e-02
IFG	ESRP1	exon_skip_200677	-4.076130e-01	3.482074e-02
TC	RBM24	exon_skip_197043	7.319478e-01	9.147176e-26
TC	HNRNPH2	exon_skip_197043	5.542684e-01	3.935290e-13
TC	ESRP1	exon_skip_197043	5.442557e-01	1.244834e-12
TC	HNRNPF	exon_skip_197043	-4.258306e-01	8.394754e-08

Top

RelatedDrugs for EIF4G3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for EIF4G3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for EIF4G3

Gene structures and expression levels for EIF4G3

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for EIF4G3

Open reading frame (ORF) annotation in the exon skipping event for EIF4G3

Infer the effects of exon skipping event on protein functional features for EIF4G3

3'-UTR located exon skipping events that lost miRNA binding sites in EIF4G3

SNVs in the skipped exons for EIF4G3

AD stage-associated exon skippint events for EIF4G3

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for EIF4G3

Correlation with RNA binding proteins (RBPs) for EIF4G3

RelatedDrugs for EIF4G3

RelatedDiseases for EIF4G3