ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for NCOA1

Gene summary

Gene information	Gene symbol	NCOA1
	Gene ID	8648
	Gene name	nuclear receptor coactivator 1
	Synonyms	F-SRC-1\|KAT13A\|RIP160\|SRC1\|bHLHe42\|bHLHe74
	Cytomap	2p23.3
	Type of gene	protein-coding
	Description	nuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1
	Modification date	20200313
	UniProtAcc	B5MCN7, Q15788,
	Context	- 28704393(Whole Exome Sequence-Based Association Analyses of Plasma amyloid-β in African and European Americans; The Atherosclerosis Risk in Communities-Neurocognitive Study)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NCOA1	GO:0000435	positive regulation of transcription from RNA polymerase II promoter by galactose	10207113
NCOA1	GO:0006351	transcription, DNA-templated	9223431
NCOA1	GO:0045893	positive regulation of transcription, DNA-templated	11891224\|15367689
NCOA1	GO:0045944	positive regulation of transcription by RNA polymerase II	15919756

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Gene structures and expression levels for NCOA1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000084676

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000407230.5	NCOA1-206:protein_coding:NCOA1	9.935717e+01	1.011730e+00	1.173605e-05	1.205486e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOA1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_100888	chr2	24556015:24556055:24564295:24564430:24584476:24584484	24564295:24564430
exon_skip_110786	chr2	24492058:24492188:24564295:24564430:24584476:24584484	24564295:24564430
exon_skip_116720	chr2	24758059:24758156:24762687:24762776:24768079:24768135	24762687:24762776
exon_skip_127788	chr2	24554389:24554573:24556015:24556055:24564295:24564371	24556015:24556055
exon_skip_140075	chr2	24554389:24554573:24556015:24556055:24564295:24564430	24556015:24556055
exon_skip_14464	chr2	24697759:24697798:24705086:24705233:24706568:24707888	24705086:24705233
exon_skip_152809	chr2	24757973:24758156:24762687:24762776:24768221:24768388	24762687:24762776
exon_skip_158654	chr2	24492058:24492188:24554389:24554573:24564295:24564430	24554389:24554573
exon_skip_168142	chr2	24762687:24762776:24768079:24768135:24768224:24768543	24768079:24768135
exon_skip_181030	chr2	24757973:24758156:24762687:24762776:24768079:24768135	24762687:24762776
exon_skip_18224	chr2	24564310:24564430:24584476:24584560:24643966:24644055	24584476:24584560
exon_skip_195510	chr2	24762687:24762776:24768079:24768135:24768221:24768271	24768079:24768135
exon_skip_211407	chr2	24693252:24693347:24697658:24697798:24705086:24705233	24697658:24697798
exon_skip_215319	chr2	24691481:24691660:24693252:24693347:24697658:24697798	24693252:24693347
exon_skip_236471	chr2	24658661:24658766:24665749:24665915:24673366:24673463	24665749:24665915
exon_skip_237036	chr2	24757973:24758156:24762687:24762776:24768224:24768543	24762687:24762776
exon_skip_248266	chr2	24584541:24584560:24643966:24644122:24658661:24658766	24643966:24644122
exon_skip_258874	chr2	24758059:24758156:24762687:24762776:24768221:24768388	24762687:24762776
exon_skip_289289	chr2	24707727:24707888:24710931:24711111:24726589:24726706	24710931:24711111
exon_skip_293152	chr2	24492058:24492188:24554389:24554573:24556015:24556055	24554389:24554573
exon_skip_296046	chr2	24757973:24758156:24762687:24762776:24768221:24768271	24762687:24762776
exon_skip_32479	chr2	24697658:24697798:24705086:24705233:24706568:24707888	24705086:24705233
exon_skip_33966	chr2	24762687:24762776:24768079:24768135:24768221:24768388	24768079:24768135
exon_skip_74536	chr2	24741784:24742186:24751982:24752156:24757973:24758156	24751982:24752156
exon_skip_77158	chr2	24762687:24762776:24768079:24768135:24768224:24768271	24768079:24768135

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for NCOA1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000406961	24564295	24564430	5UTR-5UTR
ENST00000406961	24584476	24584560	5UTR-5UTR
ENST00000348332	24643966	24644122	5UTR-5UTR
ENST00000406961	24643966	24644122	5UTR-5UTR
ENST00000348332	24665749	24665915	Frame-shift
ENST00000406961	24665749	24665915	Frame-shift
ENST00000348332	24705086	24705233	Frame-shift
ENST00000406961	24705086	24705233	Frame-shift
ENST00000348332	24710931	24711111	Frame-shift
ENST00000406961	24710931	24711111	Frame-shift
ENST00000348332	24751982	24752156	Frame-shift
ENST00000406961	24751982	24752156	Frame-shift
ENST00000348332	24693252	24693347	In-frame
ENST00000406961	24693252	24693347	In-frame
ENST00000348332	24697658	24697798	In-frame
ENST00000406961	24697658	24697798	In-frame
ENST00000348332	24762687	24762776	In-frame
ENST00000406961	24762687	24762776	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000406961	24584476	24584560	5UTR-5UTR
ENST00000348332	24665749	24665915	Frame-shift
ENST00000406961	24665749	24665915	Frame-shift
ENST00000348332	24693252	24693347	In-frame
ENST00000406961	24693252	24693347	In-frame
ENST00000348332	24697658	24697798	In-frame
ENST00000406961	24697658	24697798	In-frame
ENST00000348332	24762687	24762776	In-frame
ENST00000406961	24762687	24762776	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000406961	24584476	24584560	5UTR-5UTR
ENST00000348332	24643966	24644122	5UTR-5UTR
ENST00000406961	24643966	24644122	5UTR-5UTR
ENST00000348332	24665749	24665915	Frame-shift
ENST00000406961	24665749	24665915	Frame-shift
ENST00000348332	24705086	24705233	Frame-shift
ENST00000406961	24705086	24705233	Frame-shift
ENST00000348332	24710931	24711111	Frame-shift
ENST00000406961	24710931	24711111	Frame-shift
ENST00000348332	24693252	24693347	In-frame
ENST00000406961	24693252	24693347	In-frame
ENST00000348332	24697658	24697798	In-frame
ENST00000406961	24697658	24697798	In-frame
ENST00000348332	24762687	24762776	In-frame
ENST00000406961	24762687	24762776	In-frame

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Infer the effects of exon skipping event on protein functional features for NCOA1

p-ENSG00000084676_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000348332	6912	1441	24693252	24693347	972	1066	238	269
ENST00000406961	7306	1441	24693252	24693347	1366	1460	238	269
ENST00000348332	6912	1441	24697658	24697798	1068	1207	270	316
ENST00000406961	7306	1441	24697658	24697798	1462	1601	270	316
ENST00000348332	6912	1441	24762687	24762776	4325	4413	1355	1385
ENST00000406961	7306	1441	24762687	24762776	4719	4807	1355	1385

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000348332	6912	1441	24693252	24693347	972	1066	238	269
ENST00000406961	7306	1441	24693252	24693347	1366	1460	238	269
ENST00000348332	6912	1441	24697658	24697798	1068	1207	270	316
ENST00000406961	7306	1441	24697658	24697798	1462	1601	270	316
ENST00000348332	6912	1441	24762687	24762776	4325	4413	1355	1385
ENST00000406961	7306	1441	24762687	24762776	4719	4807	1355	1385

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000348332	6912	1441	24693252	24693347	972	1066	238	269
ENST00000406961	7306	1441	24693252	24693347	1366	1460	238	269
ENST00000348332	6912	1441	24697658	24697798	1068	1207	270	316
ENST00000406961	7306	1441	24697658	24697798	1462	1601	270	316
ENST00000348332	6912	1441	24762687	24762776	4325	4413	1355	1385
ENST00000406961	7306	1441	24762687	24762776	4719	4807	1355	1385

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q15788	238	269	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	238	269	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	238	269	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	238	269	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	278	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	278	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	309	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	309	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	1355	1385	1385	1385	Alternative sequence	ID=VSP_011738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8754792;Dbxref=PMID:8754792
Q15788	1355	1385	1385	1385	Alternative sequence	ID=VSP_011738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8754792;Dbxref=PMID:8754792
Q15788	1355	1385	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	1355	1385	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	1355	1385	1372	1372	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q15788	1355	1385	1372	1372	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q15788	1355	1385	1378	1378	Mutagenesis	Note=Does not affect sumoylation of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12529333;Dbxref=PMID:12529333
Q15788	1355	1385	1378	1378	Mutagenesis	Note=Does not affect sumoylation of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12529333;Dbxref=PMID:12529333
Q15788	1355	1385	1370	1370	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1370	1370	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1382	1382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1382	1382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q15788	238	269	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	238	269	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	238	269	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	238	269	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	278	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	278	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	309	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	309	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	1355	1385	1385	1385	Alternative sequence	ID=VSP_011738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8754792;Dbxref=PMID:8754792
Q15788	1355	1385	1385	1385	Alternative sequence	ID=VSP_011738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8754792;Dbxref=PMID:8754792
Q15788	1355	1385	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	1355	1385	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	1355	1385	1372	1372	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q15788	1355	1385	1372	1372	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q15788	1355	1385	1378	1378	Mutagenesis	Note=Does not affect sumoylation of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12529333;Dbxref=PMID:12529333
Q15788	1355	1385	1378	1378	Mutagenesis	Note=Does not affect sumoylation of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12529333;Dbxref=PMID:12529333
Q15788	1355	1385	1370	1370	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1370	1370	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1382	1382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1382	1382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q15788	238	269	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	238	269	261	266	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	238	269	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	238	269	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	272	276	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	270	316	278	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	278	283	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	288	299	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	309	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	270	316	309	319	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5NWM
Q15788	1355	1385	1385	1385	Alternative sequence	ID=VSP_011738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8754792;Dbxref=PMID:8754792
Q15788	1355	1385	1385	1385	Alternative sequence	ID=VSP_011738;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8754792;Dbxref=PMID:8754792
Q15788	1355	1385	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	1355	1385	2	1441	Chain	ID=PRO_0000094400;Note=Nuclear receptor coactivator 1
Q15788	1355	1385	1372	1372	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q15788	1355	1385	1372	1372	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q15788	1355	1385	1378	1378	Mutagenesis	Note=Does not affect sumoylation of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12529333;Dbxref=PMID:12529333
Q15788	1355	1385	1378	1378	Mutagenesis	Note=Does not affect sumoylation of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:12529333;Dbxref=PMID:12529333
Q15788	1355	1385	1370	1370	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1370	1370	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1382	1382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q15788	1355	1385	1382	1382	Sequence conflict	Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305

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3'-UTR located exon skipping events that lost miRNA binding sites in NCOA1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for NCOA1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for NCOA1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOA1

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for NCOA1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	CNOT4	exon_skip_195510	-4.132041e-01	6.195303e-08
CB	FXR2	exon_skip_195510	-4.046294e-01	1.223659e-07
CB	TRA2A	exon_skip_195510	-4.793154e-01	1.639989e-10
CB	TRA2A	exon_skip_77158	-4.497780e-01	7.734618e-09
IFG	LIN28A	exon_skip_100888	5.606063e-01	8.204757e-03
IFG	A1CF	exon_skip_18224	5.887249e-01	9.818860e-04

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RelatedDrugs for NCOA1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NCOA1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for NCOA1

Gene structures and expression levels for NCOA1

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NCOA1

Open reading frame (ORF) annotation in the exon skipping event for NCOA1

Infer the effects of exon skipping event on protein functional features for NCOA1

3'-UTR located exon skipping events that lost miRNA binding sites in NCOA1

SNVs in the skipped exons for NCOA1

AD stage-associated exon skippint events for NCOA1

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOA1

Correlation with RNA binding proteins (RBPs) for NCOA1

RelatedDrugs for NCOA1

RelatedDiseases for NCOA1