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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PRPF18 |
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Gene information | Gene symbol | PRPF18 | Gene ID | 8559 |
Gene name | pre-mRNA processing factor 18 | |
Synonyms | PRP18|hPrp18 | |
Cytomap | 10p13 | |
Type of gene | protein-coding | |
Description | pre-mRNA-splicing factor 18PRP18 homologPRP18 pre-mRNA processing factor 18 homologPRP18 pre-mRNA processing factor 18 homolog(PRPF18) | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for PRPF18 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PRPF18 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_118182 | chr10 | 13597458:13597535:13597645:13597671:13600244:13600348 | 13597645:13597671 |
exon_skip_38349 | chr10 | 13586968:13587152:13591768:13591888:13597458:13597535 | 13591768:13591888 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_118182 | MSBB_PG | 2.539535e-01 | 3.800000e-01 | -1.260465e-01 | 4.822841e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for PRPF18 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for PRPF18 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in PRPF18 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PRPF18 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PRPF18 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRPF18 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PRPF18 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | SRSF9 | exon_skip_118182 | 4.159628e-01 | 8.092663e-08 |
DLPFC | RBMS2 | exon_skip_118182 | -4.824074e-01 | 8.004394e-20 |
DLPFC | KHDRBS2 | exon_skip_118182 | 5.486631e-01 | 3.094319e-26 |
FL | SRSF9 | exon_skip_118182 | 4.072195e-01 | 8.792012e-09 |
HCC | RBMS2 | exon_skip_118182 | -6.508172e-01 | 4.922339e-34 |
HCC | RBMS3 | exon_skip_118182 | -5.310133e-01 | 4.058171e-21 |
HCC | KHDRBS2 | exon_skip_118182 | 4.097347e-01 | 2.144781e-12 |
HCC | FUBP3 | exon_skip_118182 | -4.732946e-01 | 1.555830e-16 |
PCC | RBMS2 | exon_skip_118182 | -6.035080e-01 | 2.526837e-22 |
PG | KHDRBS2 | exon_skip_118182 | 5.295657e-01 | 1.513216e-14 |
STG | RBMS2 | exon_skip_118182 | -4.028223e-01 | 1.323121e-04 |
STG | KHDRBS2 | exon_skip_118182 | 4.600993e-01 | 9.414810e-06 |
TC | RBMS2 | exon_skip_118182 | -4.017159e-01 | 1.535416e-07 |
TC | KHDRBS2 | exon_skip_118182 | 8.503274e-01 | 1.259981e-45 |
TC | SRSF9 | exon_skip_118182 | 4.258390e-01 | 2.193624e-08 |
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RelatedDrugs for PRPF18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRPF18 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |