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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for KIAA1755 |
 Gene summary |
| Gene information | Gene symbol | KIAA1755 | Gene ID | 85449 |
| Gene name | KIAA1755 | |
| Synonyms | - | |
| Cytomap | 20q11.23 | |
| Type of gene | protein-coding | |
| Description | uncharacterized protein KIAA1755RP5-1054A22.3 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for KIAA1755 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000149633
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000484362.1 | KIAA1755-204:retained_intron:KIAA1755 | 9.892629e+01 | -9.928927e-01 | 6.386162e-10 | 3.024500e-08 |
| CB | DOWN | ENST00000487506.1 | KIAA1755-205:retained_intron:KIAA1755 | 6.714491e+01 | -1.213879e+00 | 2.332832e-07 | 4.352567e-06 |
| TC | DOWN | ENST00000487506.1 | KIAA1755-205:retained_intron:KIAA1755 | 1.379705e+02 | -8.177923e-01 | 1.490925e-05 | 3.560516e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIAA1755 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_137890 | chr20 | 38218244:38218366:38219630:38219768:38222449:38222597 | 38219630:38219768 |
| exon_skip_138203 | chr20 | 38212476:38213743:38217253:38217474:38218244:38218366 | 38217253:38217474 |
| exon_skip_141784 | chr20 | 38212476:38213743:38216860:38217005:38217253:38217474 | 38216860:38217005 |
| exon_skip_197738 | chr20 | 38225665:38225781:38227154:38227240:38228147:38228240 | 38227154:38227240 |
| exon_skip_220759 | chr20 | 38241425:38241929:38245929:38246126:38260498:38260735 | 38245929:38246126 |
| exon_skip_226224 | chr20 | 38219630:38219768:38222449:38222597:38223538:38223636 | 38222449:38222597 |
| exon_skip_23294 | chr20 | 38212476:38213743:38216860:38217005:38217253:38218183 | 38216860:38217005 |
| exon_skip_249672 | chr20 | 38225684:38225781:38227154:38227240:38228147:38228240 | 38227154:38227240 |
| exon_skip_253384 | chr20 | 38212476:38213743:38217253:38217474:38218244:38218361 | 38217253:38217474 |
| exon_skip_59280 | chr20 | 38223538:38223636:38225665:38225781:38227154:38227219 | 38225665:38225781 |
| exon_skip_81556 | chr20 | 38240582:38241929:38245929:38246126:38260498:38260735 | 38245929:38246126 |
| exon_skip_85804 | chr20 | 38239528:38239725:38240582:38241929:38245929:38246126 | 38240582:38241929 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_52965 | Mayo_CB | 5.204545e-01 | 7.061194e-01 | -1.856649e-01 | 1.008277e-02 |
| exon_skip_52965 | Mayo_TC | 5.448780e-01 | 6.684416e-01 | -1.235635e-01 | 4.281263e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for KIAA1755 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000279024 | 38219630 | 38219768 | Frame-shift |
| ENST00000279024 | 38222449 | 38222597 | Frame-shift |
| ENST00000279024 | 38217253 | 38217474 | In-frame |
| ENST00000279024 | 38225665 | 38225781 | In-frame |
| ENST00000279024 | 38227154 | 38227240 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000279024 | 38222449 | 38222597 | Frame-shift |
| ENST00000279024 | 38217253 | 38217474 | In-frame |
| ENST00000279024 | 38225665 | 38225781 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000279024 | 38222449 | 38222597 | Frame-shift |
| ENST00000279024 | 38240582 | 38241929 | Frame-shift |
| ENST00000279024 | 38217253 | 38217474 | In-frame |
| ENST00000279024 | 38225665 | 38225781 | In-frame |
| ENST00000279024 | 38227154 | 38227240 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIAA1755 |
p-ENSG00000149633_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000279024 | 6446 | 1200 | 38227154 | 38227240 | 2238 | 2323 | 655 | 683 |
| ENST00000279024 | 6446 | 1200 | 38225665 | 38225781 | 2325 | 2440 | 684 | 722 |
| ENST00000279024 | 6446 | 1200 | 38217253 | 38217474 | 2952 | 3172 | 893 | 966 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000279024 | 6446 | 1200 | 38225665 | 38225781 | 2325 | 2440 | 684 | 722 |
| ENST00000279024 | 6446 | 1200 | 38217253 | 38217474 | 2952 | 3172 | 893 | 966 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000279024 | 6446 | 1200 | 38227154 | 38227240 | 2238 | 2323 | 655 | 683 |
| ENST00000279024 | 6446 | 1200 | 38225665 | 38225781 | 2325 | 2440 | 684 | 722 |
| ENST00000279024 | 6446 | 1200 | 38217253 | 38217474 | 2952 | 3172 | 893 | 966 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JYT7 | 655 | 683 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 684 | 722 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 893 | 966 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 893 | 966 | 940 | 940 | Natural variant | ID=VAR_038504;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11214970;Dbxref=dbSNP:rs760998,PMID:11214970 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JYT7 | 684 | 722 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 893 | 966 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 893 | 966 | 940 | 940 | Natural variant | ID=VAR_038504;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11214970;Dbxref=dbSNP:rs760998,PMID:11214970 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5JYT7 | 655 | 683 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 684 | 722 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 893 | 966 | 1 | 1200 | Chain | ID=PRO_0000317284;Note=Uncharacterized protein KIAA1755 |
| Q5JYT7 | 893 | 966 | 940 | 940 | Natural variant | ID=VAR_038504;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11214970;Dbxref=dbSNP:rs760998,PMID:11214970 |
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3'-UTR located exon skipping events that lost miRNA binding sites in KIAA1755 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KIAA1755 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KIAA1755 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIAA1755 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KIAA1755 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TARDBP | exon_skip_52965 | -4.232347e-01 | 3.864402e-07 |
| CB | PCBP1 | exon_skip_52965 | -4.443708e-01 | 8.408362e-08 |
| CB | RBM45 | exon_skip_52965 | 4.897424e-01 | 2.196331e-09 |
| CB | HNRNPF | exon_skip_52965 | -4.425932e-01 | 9.597669e-08 |
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RelatedDrugs for KIAA1755 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA1755 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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