|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for GAS7 |
 Gene summary |
| Gene information | Gene symbol | GAS7 | Gene ID | 8522 |
| Gene name | growth arrest specific 7 | |
| Synonyms | - | |
| Cytomap | 17p13.1 | |
| Type of gene | protein-coding | |
| Description | growth arrest-specific protein 7 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 32216967(Growth arrest specific protein 7 inhibits tau fibrillogenesis) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for GAS7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000007237
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000578599.5 | GAS7-207:protein_coding:GAS7 | 5.736316e+00 | -1.068832e+00 | 1.430416e-05 | 6.560547e-04 |
| PG | DOWN | ENST00000579158.5 | GAS7-210:protein_coding:GAS7 | 1.267883e+01 | -1.604690e+00 | 4.061131e-04 | 7.603118e-03 |
| CB | UP | ENST00000580865.5 | GAS7-213:protein_coding:GAS7 | 1.419098e+03 | 9.600819e-01 | 4.295741e-06 | 5.158542e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GAS7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_15784 | chr17 | 9981804:9981884:10019777:10019897:10036434:10036537 | 10019777:10019897 |
| exon_skip_176249 | chr17 | 9959216:9959255:9969677:9969762:9981804:9981848 | 9969677:9969762 |
| exon_skip_189902 | chr17 | 9946933:9946983:9959202:9959255:9969677:9969762 | 9959202:9959255 |
| exon_skip_197801 | chr17 | 9969677:9969762:9981804:9981884:10019777:10019894 | 9981804:9981884 |
| exon_skip_207797 | chr17 | 9959216:9959255:9981804:9981884:10019777:10019897 | 9981804:9981884 |
| exon_skip_220452 | chr17 | 9969677:9969762:9981804:9981884:10019777:10019897 | 9981804:9981884 |
| exon_skip_228756 | chr17 | 9946933:9946983:9959202:9959255:9981804:9981882 | 9959202:9959255 |
| exon_skip_253270 | chr17 | 9926730:9926769:9934166:9934244:9940126:9940200 | 9934166:9934244 |
| exon_skip_274624 | chr17 | 9981804:9981884:10019777:10019897:10026150:10026285 | 10019777:10019897 |
| exon_skip_286291 | chr17 | 9959216:9959255:9969677:9969762:9981804:9981884 | 9969677:9969762 |
| exon_skip_295893 | chr17 | 9934166:9934244:9940126:9940200:9943121:9943236 | 9940126:9940200 |
| exon_skip_50649 | chr17 | 9946933:9946983:9959202:9959255:9981804:9981884 | 9959202:9959255 |
| exon_skip_66446 | chr17 | 9959216:9959255:9981804:9981884:10019777:10019894 | 9981804:9981884 |
| exon_skip_9446 | chr17 | 9981804:9981884:10019777:10019897:10059692:10059815 | 10019777:10019897 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for GAS7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437099 | 9934166 | 9934244 | Frame-shift |
| ENST00000542249 | 9934166 | 9934244 | Frame-shift |
| ENST00000579158 | 9934166 | 9934244 | Frame-shift |
| ENST00000437099 | 9969677 | 9969762 | Frame-shift |
| ENST00000542249 | 9969677 | 9969762 | Frame-shift |
| ENST00000579158 | 9969677 | 9969762 | Frame-shift |
| ENST00000437099 | 9940126 | 9940200 | In-frame |
| ENST00000542249 | 9940126 | 9940200 | In-frame |
| ENST00000579158 | 9940126 | 9940200 | In-frame |
| ENST00000437099 | 9981804 | 9981884 | In-frame |
| ENST00000542249 | 9981804 | 9981884 | In-frame |
| ENST00000579158 | 9981804 | 9981884 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437099 | 9934166 | 9934244 | Frame-shift |
| ENST00000542249 | 9934166 | 9934244 | Frame-shift |
| ENST00000579158 | 9934166 | 9934244 | Frame-shift |
| ENST00000437099 | 9969677 | 9969762 | Frame-shift |
| ENST00000542249 | 9969677 | 9969762 | Frame-shift |
| ENST00000579158 | 9969677 | 9969762 | Frame-shift |
| ENST00000437099 | 9981804 | 9981884 | In-frame |
| ENST00000542249 | 9981804 | 9981884 | In-frame |
| ENST00000579158 | 9981804 | 9981884 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000437099 | 9934166 | 9934244 | Frame-shift |
| ENST00000542249 | 9934166 | 9934244 | Frame-shift |
| ENST00000579158 | 9934166 | 9934244 | Frame-shift |
| ENST00000437099 | 9969677 | 9969762 | Frame-shift |
| ENST00000542249 | 9969677 | 9969762 | Frame-shift |
| ENST00000579158 | 9969677 | 9969762 | Frame-shift |
| ENST00000437099 | 9940126 | 9940200 | In-frame |
| ENST00000542249 | 9940126 | 9940200 | In-frame |
| ENST00000579158 | 9940126 | 9940200 | In-frame |
| ENST00000437099 | 9959202 | 9959255 | In-frame |
| ENST00000542249 | 9959202 | 9959255 | In-frame |
| ENST00000579158 | 9959202 | 9959255 | In-frame |
| ENST00000437099 | 9981804 | 9981884 | In-frame |
| ENST00000542249 | 9981804 | 9981884 | In-frame |
| ENST00000579158 | 9981804 | 9981884 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for GAS7 |
p-ENSG00000007237_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in GAS7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for GAS7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for GAS7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_253270 | -5.342038e-01 | 3.409555e-03 | chr17 | - | 9926730 | 9926769 | 9934166 | 9934244 | 9940126 | 9940200 |
| CDR | MSBB | IFG | exon_skip_253270 | -4.712832e-01 | 1.135674e-02 | chr17 | - | 9926730 | 9926769 | 9934166 | 9934244 | 9940126 | 9940200 |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GAS7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for GAS7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for GAS7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GAS7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|