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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for RGS5 |
Gene summary |
Gene information | Gene symbol | RGS5 | Gene ID | 8490 |
Gene name | regulator of G protein signaling 5 | |
Synonyms | MST092|MST106|MST129|MSTP032|MSTP092|MSTP106|MSTP129 | |
Cytomap | 1q23.3 | |
Type of gene | protein-coding | |
Description | regulator of G-protein signaling 5 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RGS5 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | UP | ENST00000367903.7 | RGS5-202:protein_coding:RGS5 | 1.751328e+01 | 2.423945e+00 | 1.915859e-05 | 4.329521e-04 |
TC | UP | ENST00000530507.5 | RGS5-208:protein_coding:RGS5 | 4.930014e+01 | 9.392029e-01 | 5.955584e-04 | 6.600276e-03 |
TC | UP | ENST00000525894.5 | RGS5-205:retained_intron:RGS5 | 3.384802e+01 | 1.262729e+00 | 6.957241e-03 | 4.283458e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RGS5 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_145940 | chr1 | 163152650:163152716:163161915:163161976:163202792:163202835 | 163161915:163161976 |
exon_skip_150701 | chr1 | 163152550:163152716:163161915:163161976:163202792:163202835 | 163161915:163161976 |
exon_skip_156616 | chr1 | 163152668:163152716:163161915:163161976:163202792:163202835 | 163161915:163161976 |
exon_skip_229001 | chr1 | 163168258:163168368:163248530:163248598:163306233:163306329 | 163248530:163248598 |
exon_skip_264170 | chr1 | 163161915:163161976:163168258:163168368:163202792:163202898 | 163168258:163168368 |
exon_skip_88821 | chr1 | 163161954:163161976:163168258:163168368:163202792:163202835 | 163168258:163168368 |
exon_skip_90427 | chr1 | 163152650:163152716:163161915:163161976:163168258:163168368 | 163161915:163161976 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RGS5 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000313961 | 163161915 | 163161976 | Frame-shift |
ENST00000313961 | 163168258 | 163168368 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000313961 | 163168258 | 163168368 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000313961 | 163161915 | 163161976 | Frame-shift |
ENST00000313961 | 163168258 | 163168368 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RGS5 |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000313961 | 5879 | 181 | 163168258 | 163168368 | 323 | 432 | 15 | 51 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000313961 | 5879 | 181 | 163168258 | 163168368 | 323 | 432 | 15 | 51 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000313961 | 5879 | 181 | 163168258 | 163168368 | 323 | 432 | 15 | 51 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O15539 | 15 | 51 | 1 | 108 | Alternative sequence | ID=VSP_043094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15670159;Dbxref=PMID:15670159 |
O15539 | 15 | 51 | 1 | 181 | Chain | ID=PRO_0000204188;Note=Regulator of G-protein signaling 5 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O15539 | 15 | 51 | 1 | 108 | Alternative sequence | ID=VSP_043094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15670159;Dbxref=PMID:15670159 |
O15539 | 15 | 51 | 1 | 181 | Chain | ID=PRO_0000204188;Note=Regulator of G-protein signaling 5 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O15539 | 15 | 51 | 1 | 108 | Alternative sequence | ID=VSP_043094;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15670159;Dbxref=PMID:15670159 |
O15539 | 15 | 51 | 1 | 181 | Chain | ID=PRO_0000204188;Note=Regulator of G-protein signaling 5 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RGS5 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RGS5 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RGS5 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RGS5 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RGS5 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RGS5 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RGS5 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |