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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CDC42BPA |
 Gene summary |
| Gene information | Gene symbol | CDC42BPA | Gene ID | 8476 |
| Gene name | CDC42 binding protein kinase alpha | |
| Synonyms | MRCK|MRCKA|PK428 | |
| Cytomap | 1q42.13 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase MRCK alphaCDC42 binding protein kinase alpha (DMPK-like)CDC42 binding protein kinase betamyotonic dystrophy kinase-related CDC42-binding protein kinase alphamyotonic dystrophy protein kinase-like alphaser-thr protein k | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDC42BPA | GO:0006468 | protein phosphorylation | 9092543 |
| CDC42BPA | GO:0031532 | actin cytoskeleton reorganization | 9418861 |
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Gene structures and expression levels for CDC42BPA |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000143776
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000448940.5 | CDC42BPA-209:protein_coding:CDC42BPA | 5.113916e+01 | 9.044810e-01 | 1.541448e-05 | 3.621077e-03 |
| CB | UP | ENST00000366769.7 | CDC42BPA-205:protein_coding:CDC42BPA | 2.867827e+02 | 1.094002e+00 | 2.175742e-11 | 1.829068e-09 |
| CB | UP | ENST00000366764.6 | CDC42BPA-202:protein_coding:CDC42BPA | 1.304614e+03 | 8.617715e-01 | 8.956363e-10 | 3.987170e-08 |
| CB | UP | ENST00000366767.7 | CDC42BPA-204:protein_coding:CDC42BPA | 8.495565e+02 | 1.046270e+00 | 1.795286e-06 | 2.468060e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CDC42BPA |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103460 | chr1 | 226994823:226994980:227004994:227005111:227016080:227016197 | 227004994:227005111 |
| exon_skip_143331 | chr1 | 227072208:227072299:227073864:227074012:227074259:227074364 | 227073864:227074012 |
| exon_skip_145545 | chr1 | 226994823:226994980:227004994:227005111:227016080:227016129 | 227004994:227005111 |
| exon_skip_146188 | chr1 | 227051887:227051985:227068654:227068701:227069777:227069853 | 227068654:227068701 |
| exon_skip_147156 | chr1 | 227213136:227213219:227219263:227219420:227254064:227254155 | 227219263:227219420 |
| exon_skip_157447 | chr1 | 227119804:227119937:227129109:227129231:227139576:227139742 | 227129109:227129231 |
| exon_skip_162697 | chr1 | 227139576:227139742:227142945:227143024:227145489:227145737 | 227142945:227143024 |
| exon_skip_163254 | chr1 | 227073864:227074012:227074259:227074364:227080893:227080979 | 227074259:227074364 |
| exon_skip_167253 | chr1 | 227047927:227048010:227059373:227059411:227069777:227069853 | 227059373:227059411 |
| exon_skip_174477 | chr1 | 227100992:227101239:227112312:227112422:227119804:227119937 | 227112312:227112422 |
| exon_skip_18672 | chr1 | 227004994:227005111:227010878:227011063:227016080:227016129 | 227010878:227011063 |
| exon_skip_20462 | chr1 | 227160543:227160636:227193786:227193934:227199557:227199648 | 227193786:227193934 |
| exon_skip_228734 | chr1 | 227040131:227040236:227047927:227048010:227069777:227069853 | 227047927:227048010 |
| exon_skip_244337 | chr1 | 227112312:227112422:227112671:227112913:227119804:227119937 | 227112671:227112913 |
| exon_skip_250583 | chr1 | 227016927:227017050:227023263:227023347:227026055:227026152 | 227023263:227023347 |
| exon_skip_272937 | chr1 | 227147359:227147559:227160543:227160636:227193786:227193934 | 227160543:227160636 |
| exon_skip_275877 | chr1 | 227004994:227005111:227010878:227011063:227016080:227016197 | 227010878:227011063 |
| exon_skip_280219 | chr1 | 227047927:227048010:227051881:227051985:227068654:227068700 | 227051881:227051985 |
| exon_skip_44561 | chr1 | 227033334:227033415:227034655:227034794:227035471:227035607 | 227034655:227034794 |
| exon_skip_47839 | chr1 | 227047927:227048010:227051881:227051985:227068654:227068701 | 227051881:227051985 |
| exon_skip_54368 | chr1 | 227040131:227040236:227047927:227048010:227059373:227059389 | 227047927:227048010 |
| exon_skip_54860 | chr1 | 227047927:227048010:227051881:227051985:227069777:227069853 | 227051881:227051985 |
| exon_skip_60356 | chr1 | 227051881:227051985:227068654:227068701:227069777:227069853 | 227068654:227068701 |
| exon_skip_73639 | chr1 | 227193786:227193934:227199557:227199652:227213136:227213219 | 227199557:227199652 |
| exon_skip_74717 | chr1 | 227112359:227112422:227112671:227112913:227119804:227119937 | 227112671:227112913 |
| exon_skip_75287 | chr1 | 227023263:227023347:227026055:227026152:227028657:227029250 | 227026055:227026152 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_167253 | ROSMAP_DLPFC | 1.871508e-01 | 2.957447e-01 | -1.085938e-01 | 1.231256e-03 |
| exon_skip_167253 | ROSMAP_PCC | 2.564844e-01 | 3.587059e-01 | -1.022215e-01 | 4.008720e-04 |
| exon_skip_54860 | MSBB_PG | 1.689510e-01 | 2.881818e-01 | -1.192308e-01 | 6.195116e-06 |
| exon_skip_167253 | MSBB_PG | 1.655000e-01 | 3.214545e-01 | -1.559545e-01 | 8.348502e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for CDC42BPA |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000334218 | 227004994 | 227005111 | Frame-shift |
| ENST00000334218 | 227023263 | 227023347 | Frame-shift |
| ENST00000334218 | 227026055 | 227026152 | Frame-shift |
| ENST00000334218 | 227142945 | 227143024 | Frame-shift |
| ENST00000334218 | 227160543 | 227160636 | Frame-shift |
| ENST00000334218 | 227059373 | 227059411 | In-frame |
| ENST00000334218 | 227112671 | 227112913 | In-frame |
| ENST00000334218 | 227129109 | 227129231 | In-frame |
| ENST00000334218 | 227199557 | 227199652 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000334218 | 227004994 | 227005111 | Frame-shift |
| ENST00000334218 | 227023263 | 227023347 | Frame-shift |
| ENST00000334218 | 227142945 | 227143024 | Frame-shift |
| ENST00000334218 | 227160543 | 227160636 | Frame-shift |
| ENST00000334218 | 227193786 | 227193934 | Frame-shift |
| ENST00000334218 | 227047927 | 227048010 | In-frame |
| ENST00000334218 | 227059373 | 227059411 | In-frame |
| ENST00000334218 | 227112671 | 227112913 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000334218 | 227004994 | 227005111 | Frame-shift |
| ENST00000334218 | 227023263 | 227023347 | Frame-shift |
| ENST00000334218 | 227026055 | 227026152 | Frame-shift |
| ENST00000334218 | 227034655 | 227034794 | Frame-shift |
| ENST00000334218 | 227073864 | 227074012 | Frame-shift |
| ENST00000334218 | 227074259 | 227074364 | Frame-shift |
| ENST00000334218 | 227142945 | 227143024 | Frame-shift |
| ENST00000334218 | 227160543 | 227160636 | Frame-shift |
| ENST00000334218 | 227047927 | 227048010 | In-frame |
| ENST00000334218 | 227059373 | 227059411 | In-frame |
| ENST00000334218 | 227112671 | 227112913 | In-frame |
| ENST00000334218 | 227129109 | 227129231 | In-frame |
| ENST00000334218 | 227199557 | 227199652 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDC42BPA |
p-ENSG00000143776_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000334218 | 10151 | 1732 | 227199557 | 227199652 | 887 | 981 | 118 | 149 |
| ENST00000334218 | 10151 | 1732 | 227129109 | 227129231 | 1923 | 2044 | 463 | 504 |
| ENST00000334218 | 10151 | 1732 | 227112671 | 227112913 | 2180 | 2421 | 549 | 629 |
| ENST00000334218 | 10151 | 1732 | 227059373 | 227059411 | 3437 | 3474 | 968 | 980 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000334218 | 10151 | 1732 | 227112671 | 227112913 | 2180 | 2421 | 549 | 629 |
| ENST00000334218 | 10151 | 1732 | 227059373 | 227059411 | 3437 | 3474 | 968 | 980 |
| ENST00000334218 | 10151 | 1732 | 227047927 | 227048010 | 3476 | 3558 | 981 | 1008 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000334218 | 10151 | 1732 | 227199557 | 227199652 | 887 | 981 | 118 | 149 |
| ENST00000334218 | 10151 | 1732 | 227129109 | 227129231 | 1923 | 2044 | 463 | 504 |
| ENST00000334218 | 10151 | 1732 | 227112671 | 227112913 | 2180 | 2421 | 549 | 629 |
| ENST00000334218 | 10151 | 1732 | 227059373 | 227059411 | 3437 | 3474 | 968 | 980 |
| ENST00000334218 | 10151 | 1732 | 227047927 | 227048010 | 3476 | 3558 | 981 | 1008 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5VT25 | 118 | 149 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 118 | 149 | 77 | 343 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:9092543;Dbxref=PMID:9092543 |
| Q5VT25 | 463 | 504 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 463 | 504 | 437 | 820 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q5VT25 | 549 | 629 | 550 | 630 | Alternative sequence | ID=VSP_051859;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15723050;Dbxref=PMID:15723050 |
| Q5VT25 | 549 | 629 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 549 | 629 | 437 | 820 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q5VT25 | 968 | 980 | 969 | 1009 | Alternative sequence | ID=VSP_051862;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16710414,ECO:0000303|Ref.2;Dbxref=PMID:16710414 |
| Q5VT25 | 968 | 980 | 969 | 981 | Alternative sequence | ID=VSP_051860;Note=In isoform 3%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15723050,ECO:0000303|PubMed:9455484;Dbxref=PMID:15723050,PMID:9455484 |
| Q5VT25 | 968 | 980 | 969 | 969 | Alternative sequence | ID=VSP_051861;Note=In isoform 2. R->TDPVENTYVWNPSVKFHIQSRST;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 968 | 980 | 973 | 981 | Alternative sequence | ID=VSP_051863;Note=In isoform 2. CTPASKGRR->TSSEAEPVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 968 | 980 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5VT25 | 549 | 629 | 550 | 630 | Alternative sequence | ID=VSP_051859;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15723050;Dbxref=PMID:15723050 |
| Q5VT25 | 549 | 629 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 549 | 629 | 437 | 820 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q5VT25 | 968 | 980 | 969 | 1009 | Alternative sequence | ID=VSP_051862;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16710414,ECO:0000303|Ref.2;Dbxref=PMID:16710414 |
| Q5VT25 | 968 | 980 | 969 | 981 | Alternative sequence | ID=VSP_051860;Note=In isoform 3%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15723050,ECO:0000303|PubMed:9455484;Dbxref=PMID:15723050,PMID:9455484 |
| Q5VT25 | 968 | 980 | 969 | 969 | Alternative sequence | ID=VSP_051861;Note=In isoform 2. R->TDPVENTYVWNPSVKFHIQSRST;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 968 | 980 | 973 | 981 | Alternative sequence | ID=VSP_051863;Note=In isoform 2. CTPASKGRR->TSSEAEPVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 968 | 980 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 981 | 1008 | 969 | 1009 | Alternative sequence | ID=VSP_051862;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16710414,ECO:0000303|Ref.2;Dbxref=PMID:16710414 |
| Q5VT25 | 981 | 1008 | 969 | 981 | Alternative sequence | ID=VSP_051860;Note=In isoform 3%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15723050,ECO:0000303|PubMed:9455484;Dbxref=PMID:15723050,PMID:9455484 |
| Q5VT25 | 981 | 1008 | 973 | 981 | Alternative sequence | ID=VSP_051863;Note=In isoform 2. CTPASKGRR->TSSEAEPVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 981 | 1008 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q5VT25 | 118 | 149 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 118 | 149 | 77 | 343 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000269|PubMed:9092543;Dbxref=PMID:9092543 |
| Q5VT25 | 463 | 504 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 463 | 504 | 437 | 820 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q5VT25 | 549 | 629 | 550 | 630 | Alternative sequence | ID=VSP_051859;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15723050;Dbxref=PMID:15723050 |
| Q5VT25 | 549 | 629 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 549 | 629 | 437 | 820 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q5VT25 | 968 | 980 | 969 | 1009 | Alternative sequence | ID=VSP_051862;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16710414,ECO:0000303|Ref.2;Dbxref=PMID:16710414 |
| Q5VT25 | 968 | 980 | 969 | 981 | Alternative sequence | ID=VSP_051860;Note=In isoform 3%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15723050,ECO:0000303|PubMed:9455484;Dbxref=PMID:15723050,PMID:9455484 |
| Q5VT25 | 968 | 980 | 969 | 969 | Alternative sequence | ID=VSP_051861;Note=In isoform 2. R->TDPVENTYVWNPSVKFHIQSRST;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 968 | 980 | 973 | 981 | Alternative sequence | ID=VSP_051863;Note=In isoform 2. CTPASKGRR->TSSEAEPVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 968 | 980 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
| Q5VT25 | 981 | 1008 | 969 | 1009 | Alternative sequence | ID=VSP_051862;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16710414,ECO:0000303|Ref.2;Dbxref=PMID:16710414 |
| Q5VT25 | 981 | 1008 | 969 | 981 | Alternative sequence | ID=VSP_051860;Note=In isoform 3%2C isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15723050,ECO:0000303|PubMed:9455484;Dbxref=PMID:15723050,PMID:9455484 |
| Q5VT25 | 981 | 1008 | 973 | 981 | Alternative sequence | ID=VSP_051863;Note=In isoform 2. CTPASKGRR->TSSEAEPVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q5VT25 | 981 | 1008 | 1 | 1732 | Chain | ID=PRO_0000086392;Note=Serine/threonine-protein kinase MRCK alpha |
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3'-UTR located exon skipping events that lost miRNA binding sites in CDC42BPA |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CDC42BPA |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CDC42BPA |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_167253 | -3.825867e-01 | 4.450075e-02 | chr1 | - | 227047927 | 227048010 | 227059373 | 227059411 | 227069777 | 227069853 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDC42BPA |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_228734 | rs4653474 | chr1:227012399 | 2.668403e-04 | 3.735734e-02 |
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Correlation with RNA binding proteins (RBPs) for CDC42BPA |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP1 | exon_skip_18672 | -4.946335e-01 | 4.566358e-11 |
| CB | HNRNPK | exon_skip_18672 | -5.114792e-01 | 7.618402e-12 |
| CB | PCBP2 | exon_skip_18672 | -5.876352e-01 | 5.947987e-16 |
| CB | HNRNPDL | exon_skip_18672 | -4.126091e-01 | 7.879886e-08 |
| CB | HNRNPD | exon_skip_18672 | -4.031813e-01 | 1.646008e-07 |
| CB | RALYL | exon_skip_18672 | -5.663713e-01 | 1.067292e-14 |
| CB | EIF4G2 | exon_skip_18672 | -4.278040e-01 | 2.289734e-08 |
| CB | PTBP3 | exon_skip_18672 | -4.496989e-01 | 3.454641e-09 |
| CB | HNRNPL | exon_skip_18672 | -5.037594e-01 | 1.752011e-11 |
| CB | EIF4B | exon_skip_18672 | -5.090593e-01 | 9.913217e-12 |
| CB | RBM6 | exon_skip_54860 | -4.658710e-01 | 9.649552e-09 |
| CB | FUBP3 | exon_skip_54860 | 5.593725e-01 | 1.203678e-12 |
| CB | SRSF9 | exon_skip_54860 | 4.673420e-01 | 8.546276e-09 |
| CB | NUP42 | exon_skip_167253 | 6.047541e-01 | 7.936127e-16 |
| CB | TIA1 | exon_skip_214404 | 5.892423e-01 | 2.338566e-14 |
| CB | PUF60 | exon_skip_214404 | 4.207361e-01 | 2.508976e-07 |
| CB | PTBP3 | exon_skip_214404 | 4.277278e-01 | 1.505290e-07 |
| DLPFC | RBMS2 | exon_skip_54860 | -4.359650e-01 | 2.665811e-13 |
| FL | KHDRBS2 | exon_skip_275877 | -4.243506e-01 | 1.426346e-09 |
| FL | KHDRBS3 | exon_skip_275877 | -5.138463e-01 | 5.430071e-14 |
| FL | RBM45 | exon_skip_275877 | -4.046380e-01 | 9.257819e-09 |
| FL | RALYL | exon_skip_275877 | -5.375913e-01 | 2.135333e-15 |
| FL | NOVA1 | exon_skip_275877 | -4.725941e-01 | 8.543516e-12 |
| FL | HNRNPL | exon_skip_54860 | 4.838121e-01 | 1.020789e-12 |
| FL | SRSF9 | exon_skip_54860 | 4.502477e-01 | 5.042478e-11 |
| FL | NOVA1 | exon_skip_54860 | 4.093159e-01 | 3.411743e-09 |
| FL | NUP42 | exon_skip_167253 | 4.031293e-01 | 4.271355e-09 |
| FL | RBM45 | exon_skip_147156 | 4.898680e-01 | 3.646336e-13 |
| HCC | RBM6 | exon_skip_275877 | 5.021609e-01 | 7.590178e-19 |
| HCC | PCBP4 | exon_skip_275877 | 6.023907e-01 | 2.370867e-28 |
| HCC | KHDRBS3 | exon_skip_275877 | 4.356579e-01 | 4.505818e-14 |
| HCC | RBM45 | exon_skip_275877 | 4.776553e-01 | 5.768674e-17 |
| HCC | SRSF5 | exon_skip_275877 | 4.400034e-01 | 2.358219e-14 |
| HCC | RBMS2 | exon_skip_280219 | -4.533586e-01 | 9.028699e-14 |
| HCC | RBMS2 | exon_skip_54860 | -6.397637e-01 | 7.892880e-33 |
| HCC | RBM6 | exon_skip_54860 | -6.180458e-01 | 3.734917e-30 |
| HCC | CNOT4 | exon_skip_54860 | -4.031432e-01 | 4.310003e-12 |
| HCC | FUBP1 | exon_skip_54860 | -5.085656e-01 | 2.308322e-19 |
| HCC | TIA1 | exon_skip_214404 | -4.075152e-01 | 2.401130e-12 |
| HCC | TRNAU1AP | exon_skip_214404 | -4.908201e-01 | 5.880665e-18 |
| HCC | PUF60 | exon_skip_214404 | -4.743398e-01 | 1.009630e-16 |
| HCC | RALY | exon_skip_214404 | -5.413485e-01 | 3.461837e-22 |
| HCC | PTBP1 | exon_skip_214404 | -4.840929e-01 | 1.912008e-17 |
| IFG | IGF2BP2 | exon_skip_275877 | 4.336686e-01 | 2.113681e-02 |
| IFG | RBM47 | exon_skip_275877 | 4.292798e-01 | 2.262975e-02 |
| IFG | KHDRBS2 | exon_skip_275877 | -5.597399e-01 | 1.953833e-03 |
| IFG | KHDRBS3 | exon_skip_275877 | -5.042603e-01 | 6.215316e-03 |
| IFG | RALYL | exon_skip_275877 | -6.025855e-01 | 6.903041e-04 |
| IFG | NOVA1 | exon_skip_275877 | -4.802940e-01 | 9.687079e-03 |
| IFG | PCBP2 | exon_skip_206817 | -5.080572e-01 | 1.331914e-02 |
| IFG | NOVA1 | exon_skip_54860 | 4.146448e-01 | 2.824282e-02 |
| IFG | UNK | exon_skip_167253 | -4.496510e-01 | 1.636558e-02 |
| IFG | PTBP1 | exon_skip_214404 | -4.272597e-01 | 2.334532e-02 |
| PCC | RALYL | exon_skip_18672 | -4.494747e-01 | 4.351157e-12 |
| PCC | RBMS2 | exon_skip_54860 | -6.375423e-01 | 1.073509e-25 |
| PCC | RBM6 | exon_skip_54860 | -4.624796e-01 | 1.098082e-12 |
| PCC | RALY | exon_skip_214404 | -4.117578e-01 | 4.009076e-10 |
| PG | PCBP4 | exon_skip_18672 | 4.078379e-01 | 6.889720e-09 |
| PG | KHDRBS2 | exon_skip_18672 | -4.515267e-01 | 8.813292e-11 |
| PG | KHDRBS3 | exon_skip_18672 | -4.625353e-01 | 2.655699e-11 |
| PG | RALYL | exon_skip_18672 | -5.080163e-01 | 1.157303e-13 |
| STG | IGF2BP2 | exon_skip_54860 | -4.005942e-01 | 1.099790e-04 |
| STG | NOVA1 | exon_skip_54860 | 4.336963e-01 | 2.431181e-05 |
| STG | NUP42 | exon_skip_167253 | 4.347974e-01 | 2.874060e-05 |
| STG | RALYL | exon_skip_214404 | 4.557043e-01 | 1.038570e-05 |
| TC | PCBP4 | exon_skip_18672 | 4.803385e-01 | 1.294775e-10 |
| TC | KHDRBS2 | exon_skip_18672 | -6.540148e-01 | 6.806662e-21 |
| TC | KHDRBS3 | exon_skip_18672 | -5.919739e-01 | 1.667288e-16 |
| TC | NUP42 | exon_skip_18672 | -5.102341e-01 | 5.499809e-12 |
| TC | RALYL | exon_skip_18672 | -6.716207e-01 | 2.472429e-22 |
| TC | PTBP3 | exon_skip_18672 | -4.841482e-01 | 8.803634e-11 |
| TC | PCBP4 | exon_skip_99798 | 5.127398e-01 | 9.060083e-12 |
| TC | RBM6 | exon_skip_54860 | -5.327922e-01 | 6.835674e-13 |
| TC | NOVA1 | exon_skip_54860 | 4.702110e-01 | 5.181148e-10 |
| TC | NUP42 | exon_skip_167253 | 4.898735e-01 | 5.622030e-11 |
| TC | G3BP2 | exon_skip_214404 | 4.274083e-01 | 2.625644e-08 |
| TC | PTBP3 | exon_skip_214404 | 4.697356e-01 | 6.160645e-10 |
| TC | KHDRBS2 | exon_skip_74717 | 4.476328e-01 | 2.942955e-09 |
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RelatedDrugs for CDC42BPA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDC42BPA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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