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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TPST2 |
 Gene summary |
| Gene information | Gene symbol | TPST2 | Gene ID | 8459 |
| Gene name | tyrosylprotein sulfotransferase 2 | |
| Synonyms | TANGO13B|TPST-2 | |
| Cytomap | 22q12.1 | |
| Type of gene | protein-coding | |
| Description | protein-tyrosine sulfotransferase 2transport and golgi organization 13 homolog Btyrosylprotein phosphotransferase 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TPST2 | GO:0006478 | peptidyl-tyrosine sulfation | 9733778|23481380 |
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Gene structures and expression levels for TPST2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000128294
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000442495.5 | TPST2-205:protein_coding:TPST2 | 3.385376e+00 | 1.106464e+00 | 1.685849e-06 | 2.338849e-05 |
| TC | UP | ENST00000440953.5 | TPST2-204:protein_coding:TPST2 | 7.373193e-01 | 1.184836e+00 | 5.793094e-04 | 6.463943e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TPST2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_19256 | chr22 | 26528214:26528262:26532695:26532745:26536288:26536486 | 26532695:26532745 |
| exon_skip_201206 | chr22 | 26544604:26544675:26547500:26547618:26590053:26590125 | 26547500:26547618 |
| exon_skip_204131 | chr22 | 26536288:26536486:26540789:26541718:26544604:26544675 | 26540789:26541718 |
| exon_skip_69852 | chr22 | 26525746:26526267:26528214:26528262:26532695:26532745 | 26528214:26528262 |
| exon_skip_84676 | chr22 | 26541490:26541718:26543108:26543277:26544604:26544675 | 26543108:26543277 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TPST2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338754 | 26540789 | 26541718 | 3UTR-3CDS |
| ENST00000398110 | 26540789 | 26541718 | 3UTR-3CDS |
| ENST00000403880 | 26543108 | 26543277 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338754 | 26540789 | 26541718 | 3UTR-3CDS |
| ENST00000398110 | 26540789 | 26541718 | 3UTR-3CDS |
| ENST00000403880 | 26543108 | 26543277 | 3UTR-3UTR |
| ENST00000338754 | 26528214 | 26528262 | 5CDS-5UTR |
| ENST00000398110 | 26528214 | 26528262 | 5CDS-5UTR |
| ENST00000403880 | 26528214 | 26528262 | 5CDS-5UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338754 | 26540789 | 26541718 | 3UTR-3CDS |
| ENST00000398110 | 26540789 | 26541718 | 3UTR-3CDS |
| ENST00000403880 | 26543108 | 26543277 | 3UTR-3UTR |
| ENST00000338754 | 26532695 | 26532745 | In-frame |
| ENST00000398110 | 26532695 | 26532745 | In-frame |
| ENST00000403880 | 26532695 | 26532745 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TPST2 |
p-ENSG00000128294_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000338754 | 5714 | 377 | 26532695 | 26532745 | 1313 | 1362 | 347 | 363 |
| ENST00000398110 | 1985 | 377 | 26532695 | 26532745 | 1347 | 1396 | 347 | 363 |
| ENST00000403880 | 2101 | 377 | 26532695 | 26532745 | 1463 | 1512 | 347 | 363 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O60704 | 347 | 363 | 1 | 377 | Chain | ID=PRO_0000189829;Note=Protein-tyrosine sulfotransferase 2 |
| O60704 | 347 | 363 | 1 | 377 | Chain | ID=PRO_0000189829;Note=Protein-tyrosine sulfotransferase 2 |
| O60704 | 347 | 363 | 1 | 377 | Chain | ID=PRO_0000189829;Note=Protein-tyrosine sulfotransferase 2 |
| O60704 | 347 | 363 | 339 | 349 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AP1 |
| O60704 | 347 | 363 | 339 | 349 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AP1 |
| O60704 | 347 | 363 | 339 | 349 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3AP1 |
| O60704 | 347 | 363 | 26 | 377 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O60704 | 347 | 363 | 26 | 377 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O60704 | 347 | 363 | 26 | 377 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TPST2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000403880 | 26543108 | 26543277 | hsa-miR-5087 | chr22:26543143-26543150 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| Mayo | ENST00000403880 | 26543108 | 26543277 | hsa-miR-6764-3p | chr22:26543147-26543154 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| Mayo | ENST00000403880 | 26543108 | 26543277 | hsa-miR-6824-3p | chr22:26543147-26543154 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| Mayo | ENST00000403880 | 26543108 | 26543277 | hsa-miR-922 | chr22:26543233-26543240 | 8mer-1a | chr22:26543233-26543252 | 154.00 | -24.31 |
| Mayo | ENST00000403880 | 26543108 | 26543277 | hsa-miR-29b-1-5p | chr22:26543145-26543152 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| Mayo | ENST00000403880 | 26543108 | 26543277 | hsa-miR-4291 | chr22:26543234-26543241 | 8mer-1a | chr22:26543233-26543252 | 154.00 | -24.31 |
| MSBB | ENST00000403880 | 26543108 | 26543277 | hsa-miR-5087 | chr22:26543143-26543150 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| MSBB | ENST00000403880 | 26543108 | 26543277 | hsa-miR-6764-3p | chr22:26543147-26543154 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| MSBB | ENST00000403880 | 26543108 | 26543277 | hsa-miR-6824-3p | chr22:26543147-26543154 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| MSBB | ENST00000403880 | 26543108 | 26543277 | hsa-miR-922 | chr22:26543233-26543240 | 8mer-1a | chr22:26543233-26543252 | 154.00 | -24.31 |
| MSBB | ENST00000403880 | 26543108 | 26543277 | hsa-miR-29b-1-5p | chr22:26543145-26543152 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| MSBB | ENST00000403880 | 26543108 | 26543277 | hsa-miR-4291 | chr22:26543234-26543241 | 8mer-1a | chr22:26543233-26543252 | 154.00 | -24.31 |
| ROSMAP | ENST00000403880 | 26543108 | 26543277 | hsa-miR-5087 | chr22:26543143-26543150 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| ROSMAP | ENST00000403880 | 26543108 | 26543277 | hsa-miR-6764-3p | chr22:26543147-26543154 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| ROSMAP | ENST00000403880 | 26543108 | 26543277 | hsa-miR-6824-3p | chr22:26543147-26543154 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| ROSMAP | ENST00000403880 | 26543108 | 26543277 | hsa-miR-922 | chr22:26543233-26543240 | 8mer-1a | chr22:26543233-26543252 | 154.00 | -24.31 |
| ROSMAP | ENST00000403880 | 26543108 | 26543277 | hsa-miR-29b-1-5p | chr22:26543145-26543152 | 8mer-1a | chr22:26543138-26543160 | 160.00 | -25.98 |
| ROSMAP | ENST00000403880 | 26543108 | 26543277 | hsa-miR-4291 | chr22:26543234-26543241 | 8mer-1a | chr22:26543233-26543252 | 154.00 | -24.31 |
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SNVs in the skipped exons for TPST2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TPST2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TPST2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TPST2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TPST2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPST2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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