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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CUL1 |
 Gene summary |
| Gene information | Gene symbol | CUL1 | Gene ID | 8454 |
| Gene name | cullin 1 | |
| Synonyms | - | |
| Cytomap | 7q36.1 | |
| Type of gene | protein-coding | |
| Description | cullin-1CUL-1 | |
| Modification date | 20200327 | |
| UniProtAcc | A0A090N7U0, A0A0C4DGX4, A0A590UJ21, A0A590UJ50, | |
| Context | - 12354302(SEL-10 Interacts With Presenilin 1, Facilitates Its Ubiquitination, and Alters A-beta Peptide Production) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CUL1 | GO:0016567 | protein ubiquitination | 15103331 |
| CUL1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331 |
Top |
Gene structures and expression levels for CUL1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000055130
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000662132.1 | CUL1-209:protein_coding:CUL1 | 6.162214e+01 | -2.355263e+00 | 5.380843e-03 | 2.091872e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CUL1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_122542 | chr7 | 148759304:148759354:148759548:148759638:148766561:148766723 | 148759548:148759638 |
| exon_skip_16756 | chr7 | 148786551:148786599:148786989:148787120:148788557:148788674 | 148786989:148787120 |
| exon_skip_208130 | chr7 | 148767619:148767749:148783783:148783890:148783971:148783984 | 148783783:148783890 |
| exon_skip_218974 | chr7 | 148756983:148757150:148759304:148759354:148759548:148759638 | 148759304:148759354 |
| exon_skip_221024 | chr7 | 148754082:148754150:148756983:148757150:148759304:148759354 | 148756983:148757150 |
| exon_skip_230285 | chr7 | 148756993:148757150:148759304:148759354:148759548:148759638 | 148759304:148759354 |
| exon_skip_245795 | chr7 | 148790310:148790441:148792726:148792818:148797812:148797859 | 148792726:148792818 |
| exon_skip_26587 | chr7 | 148754082:148754150:148756968:148757150:148759304:148759354 | 148756968:148757150 |
| exon_skip_279224 | chr7 | 148759548:148759638:148760333:148760496:148766561:148766723 | 148760333:148760496 |
| exon_skip_282319 | chr7 | 148766565:148766723:148767619:148767749:148783783:148783890 | 148767619:148767749 |
| exon_skip_283324 | chr7 | 148797812:148797859:148797937:148798019:148798572:148798677 | 148797937:148798019 |
| exon_skip_50075 | chr7 | 148792726:148792818:148797812:148797859:148797937:148798019 | 148797812:148797859 |
| exon_skip_75279 | chr7 | 148792726:148792818:148797812:148797859:148798572:148798677 | 148797812:148797859 |
| exon_skip_93982 | chr7 | 148789750:148789826:148790310:148790441:148792726:148792818 | 148790310:148790441 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CUL1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325222 | 148760333 | 148760496 | Frame-shift |
| ENST00000409469 | 148760333 | 148760496 | Frame-shift |
| ENST00000602748 | 148760333 | 148760496 | Frame-shift |
| ENST00000325222 | 148767619 | 148767749 | Frame-shift |
| ENST00000409469 | 148767619 | 148767749 | Frame-shift |
| ENST00000602748 | 148767619 | 148767749 | Frame-shift |
| ENST00000325222 | 148797937 | 148798019 | Frame-shift |
| ENST00000409469 | 148797937 | 148798019 | Frame-shift |
| ENST00000602748 | 148797937 | 148798019 | Frame-shift |
| ENST00000325222 | 148759304 | 148759354 | In-frame |
| ENST00000409469 | 148759304 | 148759354 | In-frame |
| ENST00000602748 | 148759304 | 148759354 | In-frame |
| ENST00000325222 | 148786989 | 148787120 | In-frame |
| ENST00000409469 | 148786989 | 148787120 | In-frame |
| ENST00000602748 | 148786989 | 148787120 | In-frame |
| ENST00000325222 | 148790310 | 148790441 | In-frame |
| ENST00000409469 | 148790310 | 148790441 | In-frame |
| ENST00000602748 | 148790310 | 148790441 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325222 | 148760333 | 148760496 | Frame-shift |
| ENST00000409469 | 148760333 | 148760496 | Frame-shift |
| ENST00000602748 | 148760333 | 148760496 | Frame-shift |
| ENST00000325222 | 148759304 | 148759354 | In-frame |
| ENST00000409469 | 148759304 | 148759354 | In-frame |
| ENST00000602748 | 148759304 | 148759354 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325222 | 148760333 | 148760496 | Frame-shift |
| ENST00000409469 | 148760333 | 148760496 | Frame-shift |
| ENST00000602748 | 148760333 | 148760496 | Frame-shift |
| ENST00000325222 | 148797937 | 148798019 | Frame-shift |
| ENST00000409469 | 148797937 | 148798019 | Frame-shift |
| ENST00000602748 | 148797937 | 148798019 | Frame-shift |
| ENST00000325222 | 148756983 | 148757150 | In-frame |
| ENST00000409469 | 148756983 | 148757150 | In-frame |
| ENST00000602748 | 148756983 | 148757150 | In-frame |
| ENST00000325222 | 148759304 | 148759354 | In-frame |
| ENST00000409469 | 148759304 | 148759354 | In-frame |
| ENST00000602748 | 148759304 | 148759354 | In-frame |
| ENST00000325222 | 148783783 | 148783890 | In-frame |
| ENST00000409469 | 148783783 | 148783890 | In-frame |
| ENST00000602748 | 148783783 | 148783890 | In-frame |
| ENST00000325222 | 148792726 | 148792818 | In-frame |
| ENST00000409469 | 148792726 | 148792818 | In-frame |
| ENST00000602748 | 148792726 | 148792818 | In-frame |
| ENST00000325222 | 148797812 | 148797859 | In-frame |
| ENST00000409469 | 148797812 | 148797859 | In-frame |
| ENST00000602748 | 148797812 | 148797859 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for CUL1 |
p-ENSG00000055130_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325222 | 3081 | 776 | 148759304 | 148759354 | 764 | 813 | 161 | 178 |
| ENST00000409469 | 2874 | 776 | 148759304 | 148759354 | 1011 | 1060 | 161 | 178 |
| ENST00000602748 | 3071 | 776 | 148759304 | 148759354 | 765 | 814 | 161 | 178 |
| ENST00000325222 | 3081 | 776 | 148786989 | 148787120 | 1628 | 1758 | 449 | 493 |
| ENST00000409469 | 2874 | 776 | 148786989 | 148787120 | 1875 | 2005 | 449 | 493 |
| ENST00000602748 | 3071 | 776 | 148786989 | 148787120 | 1629 | 1759 | 449 | 493 |
| ENST00000325222 | 3081 | 776 | 148790310 | 148790441 | 1955 | 2085 | 558 | 602 |
| ENST00000409469 | 2874 | 776 | 148790310 | 148790441 | 2202 | 2332 | 558 | 602 |
| ENST00000602748 | 3071 | 776 | 148790310 | 148790441 | 1956 | 2086 | 558 | 602 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325222 | 3081 | 776 | 148759304 | 148759354 | 764 | 813 | 161 | 178 |
| ENST00000409469 | 2874 | 776 | 148759304 | 148759354 | 1011 | 1060 | 161 | 178 |
| ENST00000602748 | 3071 | 776 | 148759304 | 148759354 | 765 | 814 | 161 | 178 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325222 | 3081 | 776 | 148756983 | 148757150 | 596 | 762 | 105 | 161 |
| ENST00000409469 | 2874 | 776 | 148756983 | 148757150 | 843 | 1009 | 105 | 161 |
| ENST00000602748 | 3071 | 776 | 148756983 | 148757150 | 597 | 763 | 105 | 161 |
| ENST00000325222 | 3081 | 776 | 148759304 | 148759354 | 764 | 813 | 161 | 178 |
| ENST00000409469 | 2874 | 776 | 148759304 | 148759354 | 1011 | 1060 | 161 | 178 |
| ENST00000602748 | 3071 | 776 | 148759304 | 148759354 | 765 | 814 | 161 | 178 |
| ENST00000325222 | 3081 | 776 | 148783783 | 148783890 | 1364 | 1470 | 361 | 397 |
| ENST00000409469 | 2874 | 776 | 148783783 | 148783890 | 1611 | 1717 | 361 | 397 |
| ENST00000602748 | 3071 | 776 | 148783783 | 148783890 | 1365 | 1471 | 361 | 397 |
| ENST00000325222 | 3081 | 776 | 148792726 | 148792818 | 2087 | 2178 | 602 | 633 |
| ENST00000409469 | 2874 | 776 | 148792726 | 148792818 | 2334 | 2425 | 602 | 633 |
| ENST00000602748 | 3071 | 776 | 148792726 | 148792818 | 2088 | 2179 | 602 | 633 |
| ENST00000325222 | 3081 | 776 | 148797812 | 148797859 | 2180 | 2226 | 633 | 649 |
| ENST00000409469 | 2874 | 776 | 148797812 | 148797859 | 2427 | 2473 | 633 | 649 |
| ENST00000602748 | 3071 | 776 | 148797812 | 148797859 | 2181 | 2227 | 633 | 649 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 449 | 493 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 449 | 493 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 449 | 493 | 439 | 453 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 439 | 453 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 439 | 453 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 459 | 475 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 459 | 475 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 459 | 475 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 482 | 525 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 482 | 525 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 449 | 493 | 482 | 525 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 579 | 581 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 579 | 581 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 579 | 581 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 589 | 597 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 589 | 597 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 589 | 597 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 600 | 602 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 600 | 602 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 600 | 602 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 558 | 602 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 558 | 602 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 558 | 602 | 557 | 559 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 557 | 559 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 557 | 559 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 560 | 569 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 560 | 569 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 560 | 569 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 583 | 585 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 583 | 585 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 583 | 585 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 570 | 573 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 570 | 573 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 558 | 602 | 570 | 573 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13616 | 105 | 161 | 144 | 146 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 144 | 146 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 144 | 146 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 105 | 161 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 105 | 161 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 105 | 161 | 87 | 105 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 87 | 105 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 87 | 105 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 115 | 136 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 115 | 136 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 115 | 136 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 138 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 138 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 138 | 143 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 106 | 109 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U6G |
| Q13616 | 105 | 161 | 106 | 109 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U6G |
| Q13616 | 105 | 161 | 106 | 109 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1U6G |
| Q13616 | 105 | 161 | 111 | 114 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 111 | 114 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 105 | 161 | 111 | 114 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 159 | 165 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 168 | 171 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 178 | 187 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 161 | 178 | 172 | 177 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 361 | 397 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 361 | 397 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 361 | 397 | 359 | 361 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 359 | 361 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 359 | 361 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 363 | 382 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 363 | 382 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 363 | 382 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 389 | 404 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 389 | 404 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 389 | 404 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 383 | 387 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 383 | 387 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 361 | 397 | 383 | 387 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 600 | 602 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 600 | 602 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 600 | 602 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 616 | 621 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 616 | 621 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 616 | 621 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 602 | 633 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 602 | 633 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 602 | 633 | 605 | 612 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 605 | 612 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 605 | 612 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 613 | 615 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 613 | 615 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 613 | 615 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 622 | 628 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 622 | 628 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 622 | 628 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 633 | 645 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 633 | 645 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 602 | 633 | 633 | 645 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 633 | 649 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 633 | 649 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 633 | 649 | 1 | 776 | Chain | ID=PRO_0000119787;Note=Cullin-1 |
| Q13616 | 633 | 649 | 633 | 645 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 633 | 649 | 633 | 645 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 633 | 649 | 633 | 645 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 633 | 649 | 646 | 648 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 633 | 649 | 646 | 648 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
| Q13616 | 633 | 649 | 646 | 648 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1LDJ |
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3'-UTR located exon skipping events that lost miRNA binding sites in CUL1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CUL1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CUL1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CUL1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CUL1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CUL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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