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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CUL2 |
 Gene summary |
| Gene information | Gene symbol | CUL2 | Gene ID | 8453 |
| Gene name | cullin 2 | |
| Synonyms | - | |
| Cytomap | 10p11.21 | |
| Type of gene | protein-coding | |
| Description | cullin-2CUL-2testis secretory sperm-binding protein Li 238E | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CUL2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000108094
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000468804.5 | CUL2-207:lncRNA:CUL2 | 1.706137e+01 | 1.310222e+00 | 5.115581e-08 | 1.202841e-06 |
| CB | DOWN | ENST00000537177.5 | CUL2-209:protein_coding:CUL2 | 2.881904e+01 | -1.572780e+00 | 2.854046e-03 | 1.238423e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CUL2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104481 | chr10 | 35049683:35049765:35054434:35054539:35060874:35060924 | 35054434:35054539 |
| exon_skip_108202 | chr10 | 35035172:35035296:35038920:35039082:35044566:35044676 | 35038920:35039082 |
| exon_skip_172825 | chr10 | 35044566:35044676:35044772:35044868:35049683:35049761 | 35044772:35044868 |
| exon_skip_176338 | chr10 | 35028810:35028887:35029488:35029640:35031300:35031386 | 35029488:35029640 |
| exon_skip_203091 | chr10 | 35010292:35010442:35011848:35011964:35013699:35013713 | 35011848:35011964 |
| exon_skip_216406 | chr10 | 35010292:35010442:35011848:35011964:35013699:35013800 | 35011848:35011964 |
| exon_skip_242812 | chr10 | 35071199:35071339:35089896:35090001:35090179:35090366 | 35089896:35090001 |
| exon_skip_4710 | chr10 | 35010407:35010442:35011848:35011964:35013699:35013800 | 35011848:35011964 |
| exon_skip_65289 | chr10 | 35044566:35044676:35044772:35044868:35049683:35049765 | 35044772:35044868 |
| exon_skip_9132 | chr10 | 35011848:35011964:35013699:35013800:35016192:35016394 | 35013699:35013800 |
| exon_skip_91437 | chr10 | 35010292:35010442:35013699:35013800:35016192:35016394 | 35013699:35013800 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CUL2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374748 | 35089896 | 35090001 | 3UTR-3UTR |
| ENST00000374748 | 35044772 | 35044868 | Frame-shift |
| ENST00000374749 | 35044772 | 35044868 | Frame-shift |
| ENST00000374751 | 35044772 | 35044868 | Frame-shift |
| ENST00000374748 | 35011848 | 35011964 | In-frame |
| ENST00000374749 | 35011848 | 35011964 | In-frame |
| ENST00000374751 | 35011848 | 35011964 | In-frame |
| ENST00000374748 | 35029488 | 35029640 | In-frame |
| ENST00000374749 | 35029488 | 35029640 | In-frame |
| ENST00000374751 | 35029488 | 35029640 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374748 | 35089896 | 35090001 | 3UTR-3UTR |
| ENST00000374748 | 35044772 | 35044868 | Frame-shift |
| ENST00000374749 | 35044772 | 35044868 | Frame-shift |
| ENST00000374751 | 35044772 | 35044868 | Frame-shift |
| ENST00000374748 | 35011848 | 35011964 | In-frame |
| ENST00000374749 | 35011848 | 35011964 | In-frame |
| ENST00000374751 | 35011848 | 35011964 | In-frame |
| ENST00000374748 | 35013699 | 35013800 | In-frame |
| ENST00000374749 | 35013699 | 35013800 | In-frame |
| ENST00000374751 | 35013699 | 35013800 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000374748 | 35089896 | 35090001 | 3UTR-3UTR |
| ENST00000374748 | 35038920 | 35039082 | Frame-shift |
| ENST00000374749 | 35038920 | 35039082 | Frame-shift |
| ENST00000374751 | 35038920 | 35039082 | Frame-shift |
| ENST00000374748 | 35044772 | 35044868 | Frame-shift |
| ENST00000374749 | 35044772 | 35044868 | Frame-shift |
| ENST00000374751 | 35044772 | 35044868 | Frame-shift |
| ENST00000374748 | 35054434 | 35054539 | Frame-shift |
| ENST00000374749 | 35054434 | 35054539 | Frame-shift |
| ENST00000374751 | 35054434 | 35054539 | Frame-shift |
| ENST00000374748 | 35011848 | 35011964 | In-frame |
| ENST00000374749 | 35011848 | 35011964 | In-frame |
| ENST00000374751 | 35011848 | 35011964 | In-frame |
| ENST00000374748 | 35013699 | 35013800 | In-frame |
| ENST00000374749 | 35013699 | 35013800 | In-frame |
| ENST00000374751 | 35013699 | 35013800 | In-frame |
| ENST00000374748 | 35029488 | 35029640 | In-frame |
| ENST00000374749 | 35029488 | 35029640 | In-frame |
| ENST00000374751 | 35029488 | 35029640 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CUL2 |
p-ENSG00000108094_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374748 | 4329 | 745 | 35029488 | 35029640 | 1701 | 1852 | 462 | 512 |
| ENST00000374749 | 4225 | 745 | 35029488 | 35029640 | 1597 | 1748 | 462 | 512 |
| ENST00000374751 | 4250 | 745 | 35029488 | 35029640 | 1622 | 1773 | 462 | 512 |
| ENST00000374748 | 4329 | 745 | 35011848 | 35011964 | 2304 | 2419 | 663 | 701 |
| ENST00000374749 | 4225 | 745 | 35011848 | 35011964 | 2200 | 2315 | 663 | 701 |
| ENST00000374751 | 4250 | 745 | 35011848 | 35011964 | 2225 | 2340 | 663 | 701 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374748 | 4329 | 745 | 35013699 | 35013800 | 2202 | 2302 | 629 | 662 |
| ENST00000374749 | 4225 | 745 | 35013699 | 35013800 | 2098 | 2198 | 629 | 662 |
| ENST00000374751 | 4250 | 745 | 35013699 | 35013800 | 2123 | 2223 | 629 | 662 |
| ENST00000374748 | 4329 | 745 | 35011848 | 35011964 | 2304 | 2419 | 663 | 701 |
| ENST00000374749 | 4225 | 745 | 35011848 | 35011964 | 2200 | 2315 | 663 | 701 |
| ENST00000374751 | 4250 | 745 | 35011848 | 35011964 | 2225 | 2340 | 663 | 701 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000374748 | 4329 | 745 | 35029488 | 35029640 | 1701 | 1852 | 462 | 512 |
| ENST00000374749 | 4225 | 745 | 35029488 | 35029640 | 1597 | 1748 | 462 | 512 |
| ENST00000374751 | 4250 | 745 | 35029488 | 35029640 | 1622 | 1773 | 462 | 512 |
| ENST00000374748 | 4329 | 745 | 35013699 | 35013800 | 2202 | 2302 | 629 | 662 |
| ENST00000374749 | 4225 | 745 | 35013699 | 35013800 | 2098 | 2198 | 629 | 662 |
| ENST00000374751 | 4250 | 745 | 35013699 | 35013800 | 2123 | 2223 | 629 | 662 |
| ENST00000374748 | 4329 | 745 | 35011848 | 35011964 | 2304 | 2419 | 663 | 701 |
| ENST00000374749 | 4225 | 745 | 35011848 | 35011964 | 2200 | 2315 | 663 | 701 |
| ENST00000374751 | 4250 | 745 | 35011848 | 35011964 | 2225 | 2340 | 663 | 701 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13617 | 462 | 512 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 462 | 512 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 462 | 512 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13617 | 629 | 662 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 661 | 661 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q13617 | 629 | 662 | 661 | 661 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q13617 | 629 | 662 | 661 | 661 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13617 | 462 | 512 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 462 | 512 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 462 | 512 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 629 | 662 | 661 | 661 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q13617 | 629 | 662 | 661 | 661 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q13617 | 629 | 662 | 661 | 661 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 1 | 745 | Chain | ID=PRO_0000119790;Note=Cullin-2 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8);Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10092517,ECO:0000269|PubMed:10597293;Dbxref=PMID:10092517,PMID:10597293 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 689 | 689 | Mutagenesis | Note=Loss of conjugation with NEDD8. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10092517;Dbxref=PMID:10092517 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13617 | 663 | 701 | 681 | 681 | Sequence conflict | Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CUL2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000374748 | 35089896 | 35090001 | hsa-miR-4515 | chr10:35089965-35089972 | 8mer-1a | chr10:35089952-35089972 | 166.00 | -32.88 |
| Mayo | ENST00000374748 | 35089896 | 35090001 | hsa-miR-6793-3p | chr10:35089947-35089954 | 8mer-1a | chr10:35089931-35089954 | 156.00 | -30.30 |
| MSBB | ENST00000374748 | 35089896 | 35090001 | hsa-miR-4515 | chr10:35089965-35089972 | 8mer-1a | chr10:35089952-35089972 | 166.00 | -32.88 |
| MSBB | ENST00000374748 | 35089896 | 35090001 | hsa-miR-6793-3p | chr10:35089947-35089954 | 8mer-1a | chr10:35089931-35089954 | 156.00 | -30.30 |
| ROSMAP | ENST00000374748 | 35089896 | 35090001 | hsa-miR-4515 | chr10:35089965-35089972 | 8mer-1a | chr10:35089952-35089972 | 166.00 | -32.88 |
| ROSMAP | ENST00000374748 | 35089896 | 35090001 | hsa-miR-6793-3p | chr10:35089947-35089954 | 8mer-1a | chr10:35089931-35089954 | 156.00 | -30.30 |
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SNVs in the skipped exons for CUL2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CUL2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CUL2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CUL2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CUL2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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