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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MEGF11 |
 Gene summary |
| Gene information | Gene symbol | MEGF11 | Gene ID | 84465 |
| Gene name | multiple EGF like domains 11 | |
| Synonyms | - | |
| Cytomap | 15q22.31 | |
| Type of gene | protein-coding | |
| Description | multiple epidermal growth factor-like domains protein 11multiple EGF-like domains protein 11 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MEGF11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000157890
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000469917.1 | MEGF11-206:lncRNA:MEGF11 | 2.836227e+00 | -8.267862e-01 | 6.416035e-04 | 3.558629e-03 |
| CB | DOWN | ENST00000493192.2 | MEGF11-213:lncRNA:MEGF11 | 2.124493e+00 | -1.018353e+00 | 5.030688e-03 | 1.977482e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MEGF11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10777 | chr15 | 65909034:65909135:65909740:65909806:65913737:65913973 | 65909740:65909806 |
| exon_skip_123843 | chr15 | 65906085:65906141:65906625:65906670:65909034:65909121 | 65906625:65906670 |
| exon_skip_136656 | chr15 | 65906085:65906141:65909034:65909135:65909740:65909771 | 65909034:65909135 |
| exon_skip_138076 | chr15 | 66094402:66094494:66119086:66119186:66123899:66124000 | 66119086:66119186 |
| exon_skip_140884 | chr15 | 66123899:66124000:66128306:66128411:66253605:66253737 | 66128306:66128411 |
| exon_skip_152288 | chr15 | 65916157:65916276:65916598:65916956:65917966:65918094 | 65916598:65916956 |
| exon_skip_173271 | chr15 | 65909034:65909135:65909740:65909806:65913737:65913818 | 65909740:65909806 |
| exon_skip_173896 | chr15 | 65929721:65929883:65930823:65930943:65957547:65957721 | 65930823:65930943 |
| exon_skip_197487 | chr15 | 65916157:65916276:65916828:65916956:65917966:65918094 | 65916828:65916956 |
| exon_skip_220851 | chr15 | 65909034:65909135:65909740:65909806:65912082:65912200 | 65909740:65909806 |
| exon_skip_229337 | chr15 | 65909740:65909806:65912082:65912200:65913737:65913818 | 65912082:65912200 |
| exon_skip_254874 | chr15 | 65982242:65982488:66094402:66094494:66119086:66119186 | 66094402:66094494 |
| exon_skip_258303 | chr15 | 65916148:65916276:65916828:65916956:65917966:65918094 | 65916828:65916956 |
| exon_skip_267854 | chr15 | 65909740:65909806:65909916:65909986:65913737:65914118 | 65909916:65909986 |
| exon_skip_268573 | chr15 | 65906085:65906141:65909034:65909121:65909740:65909771 | 65909034:65909121 |
| exon_skip_274830 | chr15 | 65898733:65898934:65902496:65902537:65906085:65906141 | 65902496:65902537 |
| exon_skip_3523 | chr15 | 65909740:65909806:65909916:65909986:65913737:65913973 | 65909916:65909986 |
| exon_skip_52741 | chr15 | 65909740:65909806:65912082:65912200:65913737:65913973 | 65912082:65912200 |
| exon_skip_54681 | chr15 | 65916148:65916276:65916598:65916956:65917966:65918094 | 65916598:65916956 |
| exon_skip_77770 | chr15 | 65906085:65906141:65906625:65906670:65909034:65909135 | 65906625:65906670 |
| exon_skip_91571 | chr15 | 65917966:65918094:65922338:65922472:65922823:65922969 | 65922338:65922472 |
| exon_skip_96394 | chr15 | 65912082:65912200:65913737:65913973:65915470:65915598 | 65913737:65913973 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_229337 | Mayo_CB | 5.592647e-01 | 6.675385e-01 | -1.082738e-01 | 6.136129e-03 |
| exon_skip_197487 | Mayo_CB | 7.371951e-01 | 8.637879e-01 | -1.265928e-01 | 6.173232e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for MEGF11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MEGF11 |
p-ENSG00000157890_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MEGF11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MEGF11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MEGF11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MEGF11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_140884 | rs7170773 | chr15:66227169 | 6.311529e-05 | 1.200640e-02 |
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Correlation with RNA binding proteins (RBPs) for MEGF11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_197487 | -4.573599e-01 | 5.105509e-09 |
| CB | SAMD4A | exon_skip_197487 | -5.588373e-01 | 1.569138e-13 |
| CB | CNOT4 | exon_skip_197487 | -5.124299e-01 | 2.782890e-11 |
| CB | RBM4B | exon_skip_197487 | -4.992273e-01 | 1.057740e-10 |
| CB | RBM6 | exon_skip_173896 | -4.030274e-01 | 6.601516e-07 |
| CB | CNOT4 | exon_skip_173896 | -4.196720e-01 | 2.005389e-07 |
| CB | NUP42 | exon_skip_173896 | 4.422254e-01 | 3.590024e-08 |
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RelatedDrugs for MEGF11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MEGF11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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