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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRAF7 |
 Gene summary |
| Gene information | Gene symbol | TRAF7 | Gene ID | 84231 |
| Gene name | TNF receptor associated factor 7 | |
| Synonyms | CAFDADD|RFWD1|RNF119 | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRAF7RING finger and WD repeat-containing protein 1RING finger protein 119RING-type E3 ubiquitin transferase TRAF7TNF receptor-associated factor 7, E3 ubiquitin protein ligasering finger and WD repeat domain 1 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A087WUB0, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRAF7 | GO:0000185 | activation of MAPKKK activity | 14743216 |
| TRAF7 | GO:0006915 | apoptotic process | 15001576 |
| TRAF7 | GO:0016567 | protein ubiquitination | 14743216 |
| TRAF7 | GO:0043410 | positive regulation of MAPK cascade | 15001576 |
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Gene structures and expression levels for TRAF7 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000131653
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000569686.5 | TRAF7-206:retained_intron:TRAF7 | 2.735484e+00 | 1.033355e+00 | 1.320328e-02 | 4.353097e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRAF7 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_118049 | chr16 | 2168077:2168168:2170614:2170730:2171264:2171356 | 2170614:2170730 |
| exon_skip_220386 | chr16 | 2171264:2171356:2171572:2171605:2172191:2172374 | 2171572:2171605 |
| exon_skip_253426 | chr16 | 2170614:2170730:2171264:2171356:2171572:2171605 | 2171264:2171356 |
| exon_skip_279228 | chr16 | 2175834:2175953:2176049:2176180:2176265:2176384 | 2176049:2176180 |
| exon_skip_63687 | chr16 | 2171572:2171605:2172191:2172374:2172465:2172589 | 2172191:2172374 |
| exon_skip_94345 | chr16 | 2173921:2174048:2174251:2174333:2175111:2175150 | 2174251:2174333 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRAF7 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326181 | 2174251 | 2174333 | Frame-shift |
| ENST00000326181 | 2170614 | 2170730 | In-frame |
| ENST00000326181 | 2171264 | 2171356 | In-frame |
| ENST00000326181 | 2176049 | 2176180 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326181 | 2171572 | 2171605 | Frame-shift |
| ENST00000326181 | 2172191 | 2172374 | Frame-shift |
| ENST00000326181 | 2174251 | 2174333 | Frame-shift |
| ENST00000326181 | 2170614 | 2170730 | In-frame |
| ENST00000326181 | 2171264 | 2171356 | In-frame |
| ENST00000326181 | 2176049 | 2176180 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRAF7 |
p-ENSG00000131653_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000326181 | 3717 | 670 | 2170614 | 2170730 | 365 | 480 | 77 | 116 |
| ENST00000326181 | 3717 | 670 | 2171264 | 2171356 | 482 | 573 | 116 | 147 |
| ENST00000326181 | 3717 | 670 | 2176049 | 2176180 | 1880 | 2010 | 582 | 626 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000326181 | 3717 | 670 | 2170614 | 2170730 | 365 | 480 | 77 | 116 |
| ENST00000326181 | 3717 | 670 | 2171264 | 2171356 | 482 | 573 | 116 | 147 |
| ENST00000326181 | 3717 | 670 | 2176049 | 2176180 | 1880 | 2010 | 582 | 626 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6Q0C0 | 77 | 116 | 1 | 670 | Chain | ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7 |
| Q6Q0C0 | 77 | 116 | 88 | 88 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q6Q0C0 | 77 | 116 | 91 | 91 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q6Q0C0 | 116 | 147 | 1 | 670 | Chain | ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7 |
| Q6Q0C0 | 116 | 147 | 131 | 165 | Zinc finger | Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175 |
| Q6Q0C0 | 582 | 626 | 1 | 670 | Chain | ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7 |
| Q6Q0C0 | 582 | 626 | 557 | 594 | Repeat | Note=WD 5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q6Q0C0 | 582 | 626 | 597 | 638 | Repeat | Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6Q0C0 | 77 | 116 | 1 | 670 | Chain | ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7 |
| Q6Q0C0 | 77 | 116 | 88 | 88 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q6Q0C0 | 77 | 116 | 91 | 91 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q6Q0C0 | 116 | 147 | 1 | 670 | Chain | ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7 |
| Q6Q0C0 | 116 | 147 | 131 | 165 | Zinc finger | Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175 |
| Q6Q0C0 | 582 | 626 | 1 | 670 | Chain | ID=PRO_0000051296;Note=E3 ubiquitin-protein ligase TRAF7 |
| Q6Q0C0 | 582 | 626 | 557 | 594 | Repeat | Note=WD 5;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q6Q0C0 | 582 | 626 | 597 | 638 | Repeat | Note=WD 6;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRAF7 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TRAF7 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRAF7 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRAF7 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRAF7 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TRAF7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAF7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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