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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for USP44 |
Gene summary |
Gene information | Gene symbol | USP44 | Gene ID | 84101 |
Gene name | ubiquitin specific peptidase 44 | |
Synonyms | - | |
Cytomap | 12q22 | |
Type of gene | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase 44deubiquitinating enzyme 44ubiquitin specific protease 44ubiquitin thioesterase 44ubiquitin thiolesterase 44ubiquitin-specific-processing protease 44 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
USP44 | GO:0016579 | protein deubiquitination | 14715245|17443180|20402667 |
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Gene structures and expression levels for USP44 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000537435.2 | USP44-203:protein_coding:USP44 | 1.682990e+01 | 8.472025e-01 | 5.939599e-05 | 4.763615e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for USP44 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109618 | chr12 | 95533923:95534326:95535373:95535426:95548771:95548819 | 95535373:95535426 |
exon_skip_152602 | chr12 | 95518154:95518353:95524680:95524788:95532829:95534326 | 95524680:95524788 |
exon_skip_216577 | chr12 | 95524680:95524788:95528807:95529002:95532829:95534326 | 95528807:95529002 |
exon_skip_233100 | chr12 | 95518154:95518353:95520997:95521202:95524680:95524788 | 95520997:95521202 |
exon_skip_28587 | chr12 | 95518143:95518353:95520997:95521202:95524680:95524788 | 95520997:95521202 |
exon_skip_55873 | chr12 | 95520997:95521202:95524680:95524788:95528807:95529000 | 95524680:95524788 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for USP44 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000258499 | 95520997 | 95521202 | Frame-shift |
ENST00000393091 | 95520997 | 95521202 | Frame-shift |
ENST00000537435 | 95520997 | 95521202 | Frame-shift |
ENST00000258499 | 95524680 | 95524788 | Frame-shift |
ENST00000393091 | 95524680 | 95524788 | Frame-shift |
ENST00000537435 | 95524680 | 95524788 | Frame-shift |
ENST00000258499 | 95528807 | 95529002 | Frame-shift |
ENST00000393091 | 95528807 | 95529002 | Frame-shift |
ENST00000537435 | 95528807 | 95529002 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000258499 | 95528807 | 95529002 | Frame-shift |
ENST00000393091 | 95528807 | 95529002 | Frame-shift |
ENST00000537435 | 95528807 | 95529002 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000258499 | 95520997 | 95521202 | Frame-shift |
ENST00000393091 | 95520997 | 95521202 | Frame-shift |
ENST00000537435 | 95520997 | 95521202 | Frame-shift |
ENST00000258499 | 95524680 | 95524788 | Frame-shift |
ENST00000393091 | 95524680 | 95524788 | Frame-shift |
ENST00000537435 | 95524680 | 95524788 | Frame-shift |
ENST00000258499 | 95528807 | 95529002 | Frame-shift |
ENST00000393091 | 95528807 | 95529002 | Frame-shift |
ENST00000537435 | 95528807 | 95529002 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for USP44 |
p-ENSG00000136014_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in USP44 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for USP44 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for USP44 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for USP44 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for USP44 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for USP44 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP44 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |