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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SPOP |
 Gene summary |
| Gene information | Gene symbol | SPOP | Gene ID | 8405 |
| Gene name | speckle type BTB/POZ protein | |
| Synonyms | BTBD32|TEF2 | |
| Cytomap | 17q21.33 | |
| Type of gene | protein-coding | |
| Description | speckle-type POZ proteinHIB homolog 1roadkill homolog 1 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SPOP |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000121067
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000509079.6 | SPOP-214:protein_coding:SPOP | 1.045452e+02 | 8.069489e-01 | 1.596737e-03 | 7.640533e-03 |
| CB | DOWN | ENST00000510476.5 | SPOP-217:protein_coding:SPOP | 6.786772e-01 | -1.034377e+00 | 6.627653e-03 | 2.480413e-02 |
| CB | UP | ENST00000513080.6 | SPOP-218:nonsense_mediated_decay:SPOP | 5.000333e+00 | 1.806080e+00 | 9.449825e-03 | 3.319441e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SPOP |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101503 | chr17 | 49619319:49619385:49620621:49620670:49621946:49622067 | 49620621:49620670 |
| exon_skip_14485 | chr17 | 49611381:49611457:49618504:49618563:49618981:49619106 | 49618504:49618563 |
| exon_skip_160025 | chr17 | 49636759:49636809:49668027:49668078:49675895:49675992 | 49668027:49668078 |
| exon_skip_170082 | chr17 | 49622733:49622876:49668027:49668078:49677933:49678000 | 49668027:49668078 |
| exon_skip_19286 | chr17 | 49622733:49622876:49668027:49668078:49675895:49676016 | 49668027:49668078 |
| exon_skip_202914 | chr17 | 49622733:49622876:49675895:49676016:49677933:49678000 | 49675895:49676016 |
| exon_skip_206062 | chr17 | 49622050:49622067:49622206:49622283:49622733:49622876 | 49622206:49622283 |
| exon_skip_206990 | chr17 | 49622733:49622876:49636759:49636809:49675895:49675992 | 49636759:49636809 |
| exon_skip_229990 | chr17 | 49607874:49607929:49611280:49611457:49618981:49619108 | 49611280:49611457 |
| exon_skip_23588 | chr17 | 49622733:49622876:49636759:49636809:49677933:49678000 | 49636759:49636809 |
| exon_skip_243574 | chr17 | 49622733:49622876:49636759:49636809:49668027:49668043 | 49636759:49636809 |
| exon_skip_269250 | chr17 | 49636759:49636809:49668027:49668078:49677933:49678000 | 49668027:49668078 |
| exon_skip_276278 | chr17 | 49607250:49607372:49607874:49607929:49611280:49611318 | 49607874:49607929 |
| exon_skip_281420 | chr17 | 49622733:49622876:49668027:49668078:49675895:49675992 | 49668027:49668078 |
| exon_skip_29407 | chr17 | 49622733:49622876:49636759:49636809:49646926:49647122 | 49636759:49636809 |
| exon_skip_47632 | chr17 | 49622733:49622876:49636759:49636809:49675895:49676016 | 49636759:49636809 |
| exon_skip_50539 | chr17 | 49611280:49611457:49618504:49618563:49618981:49619108 | 49618504:49618563 |
| exon_skip_51919 | chr17 | 49668027:49668078:49675895:49676016:49677933:49678000 | 49675895:49676016 |
| exon_skip_52087 | chr17 | 49636759:49636809:49668027:49668078:49675895:49676016 | 49668027:49668078 |
| exon_skip_70112 | chr17 | 49619356:49619385:49620621:49620670:49621946:49622067 | 49620621:49620670 |
| exon_skip_82018 | chr17 | 49622733:49622876:49636759:49636809:49668027:49668051 | 49636759:49636809 |
| exon_skip_90768 | chr17 | 49636759:49636809:49675895:49676016:49677933:49678000 | 49675895:49676016 |
| exon_skip_92520 | chr17 | 49611381:49611457:49618504:49618563:49618981:49619108 | 49618504:49618563 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SPOP |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347630 | 49636759 | 49636809 | 3UTR-3UTR |
| ENST00000393328 | 49675895 | 49676016 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347630 | 49636759 | 49636809 | 3UTR-3UTR |
| ENST00000393328 | 49675895 | 49676016 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347630 | 49636759 | 49636809 | 3UTR-3UTR |
| ENST00000393328 | 49675895 | 49676016 | 3UTR-3UTR |
| ENST00000347630 | 49607874 | 49607929 | Frame-shift |
| ENST00000393328 | 49607874 | 49607929 | Frame-shift |
| ENST00000503676 | 49607874 | 49607929 | Frame-shift |
| ENST00000504102 | 49607874 | 49607929 | Frame-shift |
| ENST00000347630 | 49611280 | 49611457 | Frame-shift |
| ENST00000393328 | 49611280 | 49611457 | Frame-shift |
| ENST00000503676 | 49611280 | 49611457 | Frame-shift |
| ENST00000504102 | 49611280 | 49611457 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SPOP |
p-ENSG00000121067_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SPOP |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6742-3p | chr17:49675941-49675948 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| Mayo | ENST00000347630 | 49636759 | 49636809 | hsa-miR-7152-5p | chr17:49636799-49636806 | 8mer-1a | chr17:49636784-49636806 | 147.00 | -14.68 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-5691 | chr17:49676001-49676008 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6879-3p | chr17:49675995-49676002 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6773-3p | chr17:49675997-49676004 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6787-3p | chr17:49675965-49675972 | 8mer-1a | chr17:49675952-49675975 | 170.00 | -32.32 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6791-3p | chr17:49675945-49675952 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6805-3p | chr17:49676001-49676008 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-5001-3p | chr17:49675922-49675929 | 8mer-1a | chr17:49675908-49675930 | 157.00 | -28.83 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6890-3p | chr17:49675958-49675965 | 8mer-1a | chr17:49675952-49675975 | 170.00 | -32.32 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6829-3p | chr17:49675945-49675952 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-4634 | chr17:49675973-49675980 | 8mer-1a | chr17:49675965-49675987 | 171.00 | -27.46 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6836-3p | chr17:49675946-49675953 | 8mer-1a | chr17:49675936-49675957 | 160.00 | -19.53 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-3152-5p | chr17:49675947-49675954 | 8mer-1a | chr17:49675936-49675957 | 160.00 | -19.53 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-500b-3p | chr17:49675993-49676000 | 8mer-1a | chr17:49675978-49676001 | 155.00 | -30.23 |
| Mayo | ENST00000393328 | 49675895 | 49676016 | hsa-miR-504-3p | chr17:49675983-49675990 | 8mer-1a | chr17:49675971-49675993 | 159.00 | -35.53 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6742-3p | chr17:49675941-49675948 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| MSBB | ENST00000347630 | 49636759 | 49636809 | hsa-miR-7152-5p | chr17:49636799-49636806 | 8mer-1a | chr17:49636784-49636806 | 147.00 | -14.68 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-5691 | chr17:49676001-49676008 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6879-3p | chr17:49675995-49676002 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6773-3p | chr17:49675997-49676004 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6787-3p | chr17:49675965-49675972 | 8mer-1a | chr17:49675952-49675975 | 170.00 | -32.32 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6791-3p | chr17:49675945-49675952 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6805-3p | chr17:49676001-49676008 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-5001-3p | chr17:49675922-49675929 | 8mer-1a | chr17:49675908-49675930 | 157.00 | -28.83 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6890-3p | chr17:49675958-49675965 | 8mer-1a | chr17:49675952-49675975 | 170.00 | -32.32 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6829-3p | chr17:49675945-49675952 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-4634 | chr17:49675973-49675980 | 8mer-1a | chr17:49675965-49675987 | 171.00 | -27.46 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6836-3p | chr17:49675946-49675953 | 8mer-1a | chr17:49675936-49675957 | 160.00 | -19.53 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-3152-5p | chr17:49675947-49675954 | 8mer-1a | chr17:49675936-49675957 | 160.00 | -19.53 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-500b-3p | chr17:49675993-49676000 | 8mer-1a | chr17:49675978-49676001 | 155.00 | -30.23 |
| MSBB | ENST00000393328 | 49675895 | 49676016 | hsa-miR-504-3p | chr17:49675983-49675990 | 8mer-1a | chr17:49675971-49675993 | 159.00 | -35.53 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6742-3p | chr17:49675941-49675948 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| ROSMAP | ENST00000347630 | 49636759 | 49636809 | hsa-miR-7152-5p | chr17:49636799-49636806 | 8mer-1a | chr17:49636784-49636806 | 147.00 | -14.68 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-5691 | chr17:49676001-49676008 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6879-3p | chr17:49675995-49676002 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6773-3p | chr17:49675997-49676004 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6787-3p | chr17:49675965-49675972 | 8mer-1a | chr17:49675952-49675975 | 170.00 | -32.32 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6791-3p | chr17:49675945-49675952 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6805-3p | chr17:49676001-49676008 | 8mer-1a | chr17:49675995-49676014 | 160.00 | -19.73 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-5001-3p | chr17:49675922-49675929 | 8mer-1a | chr17:49675908-49675930 | 157.00 | -28.83 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6890-3p | chr17:49675958-49675965 | 8mer-1a | chr17:49675952-49675975 | 170.00 | -32.32 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6829-3p | chr17:49675945-49675952 | 8mer-1a | chr17:49675933-49675952 | 161.00 | -24.59 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-4634 | chr17:49675973-49675980 | 8mer-1a | chr17:49675965-49675987 | 171.00 | -27.46 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-6836-3p | chr17:49675946-49675953 | 8mer-1a | chr17:49675936-49675957 | 160.00 | -19.53 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-3152-5p | chr17:49675947-49675954 | 8mer-1a | chr17:49675936-49675957 | 160.00 | -19.53 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-500b-3p | chr17:49675993-49676000 | 8mer-1a | chr17:49675978-49676001 | 155.00 | -30.23 |
| ROSMAP | ENST00000393328 | 49675895 | 49676016 | hsa-miR-504-3p | chr17:49675983-49675990 | 8mer-1a | chr17:49675971-49675993 | 159.00 | -35.53 |
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SNVs in the skipped exons for SPOP |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SPOP |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SPOP |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SPOP |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | NUP42 | exon_skip_243574 | 5.311889e-01 | 4.466527e-12 |
| FL | RALYL | exon_skip_170082 | 4.057331e-01 | 4.382080e-09 |
| HCC | PTBP1 | exon_skip_170082 | -5.744322e-01 | 2.281432e-25 |
| HCC | RBM41 | exon_skip_170082 | -4.061711e-01 | 2.876837e-12 |
| HCC | HNRNPF | exon_skip_170082 | -5.493039e-01 | 6.403237e-23 |
| IFG | PTBP1 | exon_skip_170082 | -4.388214e-01 | 1.948797e-02 |
| PG | RALYL | exon_skip_170082 | 4.886497e-01 | 7.886206e-12 |
| PG | CELF1 | exon_skip_170082 | 4.340786e-01 | 2.178280e-09 |
| STG | RALYL | exon_skip_170082 | 4.006634e-01 | 1.448589e-04 |
| TC | RALYL | exon_skip_170082 | 5.111131e-01 | 4.988448e-12 |
| TC | EWSR1 | exon_skip_170082 | 4.422336e-01 | 4.778487e-09 |
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RelatedDrugs for SPOP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPOP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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