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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for STK40 |
 Gene summary |
| Gene information | Gene symbol | STK40 | Gene ID | 83931 |
| Gene name | serine/threonine kinase 40 | |
| Synonyms | SHIK|SgK495 | |
| Cytomap | 1p34.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 40SINK-homologous serine/threonine-protein kinaseSer/Thr-like kinasesugen kinase 495 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8N2I9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for STK40 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000196182
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STK40 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_11270 | chr1 | 36361221:36361340:36367852:36368084:36385723:36385768 | 36367852:36368084 |
| exon_skip_135229 | chr1 | 36358737:36358822:36361221:36361340:36385723:36385768 | 36361221:36361340 |
| exon_skip_149916 | chr1 | 36358239:36358382:36358737:36358837:36361221:36361340 | 36358737:36358837 |
| exon_skip_151303 | chr1 | 36343860:36343979:36344120:36344264:36348700:36348815 | 36344120:36344264 |
| exon_skip_159534 | chr1 | 36367861:36368084:36372649:36372774:36385723:36385876 | 36372649:36372774 |
| exon_skip_185336 | chr1 | 36367854:36368084:36372649:36372774:36385723:36385768 | 36372649:36372774 |
| exon_skip_186023 | chr1 | 36361221:36361340:36367848:36368084:36385723:36385768 | 36367848:36368084 |
| exon_skip_212383 | chr1 | 36361221:36361340:36367848:36368084:36385723:36385876 | 36367848:36368084 |
| exon_skip_226703 | chr1 | 36367854:36368084:36372649:36372774:36385723:36385876 | 36372649:36372774 |
| exon_skip_269781 | chr1 | 36361221:36361340:36367852:36368084:36385723:36385876 | 36367852:36368084 |
| exon_skip_5407 | chr1 | 36358239:36358382:36358737:36358822:36361221:36361340 | 36358737:36358822 |
| exon_skip_55023 | chr1 | 36339624:36341973:36343364:36343448:36343860:36343979 | 36343364:36343448 |
| exon_skip_62148 | chr1 | 36358737:36358822:36361221:36361340:36385723:36385876 | 36361221:36361340 |
| exon_skip_91710 | chr1 | 36361221:36361340:36367852:36368084:36385723:36385879 | 36367852:36368084 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STK40 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373132 | 36361221 | 36361340 | 3UTR-3CDS |
| ENST00000373129 | 36367848 | 36368084 | 3UTR-3UTR |
| ENST00000373129 | 36343364 | 36343448 | Frame-shift |
| ENST00000373132 | 36343364 | 36343448 | Frame-shift |
| ENST00000373129 | 36358737 | 36358822 | Frame-shift |
| ENST00000373132 | 36358737 | 36358822 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373132 | 36361221 | 36361340 | 3UTR-3CDS |
| ENST00000373129 | 36367848 | 36368084 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373132 | 36361221 | 36361340 | 3UTR-3CDS |
| ENST00000373129 | 36367848 | 36368084 | 3UTR-3UTR |
| ENST00000373129 | 36343364 | 36343448 | Frame-shift |
| ENST00000373132 | 36343364 | 36343448 | Frame-shift |
| ENST00000373129 | 36344120 | 36344264 | Frame-shift |
| ENST00000373132 | 36344120 | 36344264 | Frame-shift |
| ENST00000373129 | 36358737 | 36358822 | Frame-shift |
| ENST00000373132 | 36358737 | 36358822 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for STK40 |
p-ENSG00000196182_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in STK40 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4680-3p | chr1:36367963-36367970 | 8mer-1a | chr1:36367958-36367978 | 163.00 | -19.82 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-6754-5p | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-12128 | chr1:36367897-36367904 | 8mer-1a | chr1:36367876-36367904 | 151.00 | -22.48 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-320e | chr1:36367981-36367988 | 8mer-1a | chr1:36367971-36367995 | 161.00 | -25.10 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4441 | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-3194-3p | chr1:36368020-36368027 | 8mer-1a | chr1:36368006-36368028 | 168.00 | -30.17 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-1306-5p | chr1:36367929-36367936 | 8mer-1a | chr1:36367918-36367939 | 156.00 | -22.87 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4270 | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4793-5p | chr1:36367875-36367882 | 8mer-1a | chr1:36367870-36367894 | 147.00 | -21.88 |
| Mayo | ENST00000373129 | 36367848 | 36368084 | hsa-miR-3690 | chr1:36367872-36367879 | 8mer-1a | chr1:36367857-36367880 | 146.00 | -25.49 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4680-3p | chr1:36367963-36367970 | 8mer-1a | chr1:36367958-36367978 | 163.00 | -19.82 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-6754-5p | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-12128 | chr1:36367897-36367904 | 8mer-1a | chr1:36367876-36367904 | 151.00 | -22.48 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-320e | chr1:36367981-36367988 | 8mer-1a | chr1:36367971-36367995 | 161.00 | -25.10 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4441 | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-3194-3p | chr1:36368020-36368027 | 8mer-1a | chr1:36368006-36368028 | 168.00 | -30.17 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-1306-5p | chr1:36367929-36367936 | 8mer-1a | chr1:36367918-36367939 | 156.00 | -22.87 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4270 | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4793-5p | chr1:36367875-36367882 | 8mer-1a | chr1:36367870-36367894 | 147.00 | -21.88 |
| MSBB | ENST00000373129 | 36367848 | 36368084 | hsa-miR-3690 | chr1:36367872-36367879 | 8mer-1a | chr1:36367857-36367880 | 146.00 | -25.49 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4680-3p | chr1:36367963-36367970 | 8mer-1a | chr1:36367958-36367978 | 163.00 | -19.82 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-6754-5p | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-12128 | chr1:36367897-36367904 | 8mer-1a | chr1:36367876-36367904 | 151.00 | -22.48 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-320e | chr1:36367981-36367988 | 8mer-1a | chr1:36367971-36367995 | 161.00 | -25.10 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4441 | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-3194-3p | chr1:36368020-36368027 | 8mer-1a | chr1:36368006-36368028 | 168.00 | -30.17 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-1306-5p | chr1:36367929-36367936 | 8mer-1a | chr1:36367918-36367939 | 156.00 | -22.87 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4270 | chr1:36367896-36367903 | 8mer-1a | chr1:36367884-36367903 | 168.00 | -32.41 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-4793-5p | chr1:36367875-36367882 | 8mer-1a | chr1:36367870-36367894 | 147.00 | -21.88 |
| ROSMAP | ENST00000373129 | 36367848 | 36368084 | hsa-miR-3690 | chr1:36367872-36367879 | 8mer-1a | chr1:36367857-36367880 | 146.00 | -25.49 |
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SNVs in the skipped exons for STK40 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STK40 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK40 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for STK40 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for STK40 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK40 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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