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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for FERMT3 |
Gene summary |
Gene information | Gene symbol | FERMT3 | Gene ID | 83706 |
Gene name | fermitin family member 3 | |
Synonyms | KIND3|MIG-2|MIG2B|UNC112C|URP2|URP2SF | |
Cytomap | 11q13.1 | |
Type of gene | protein-coding | |
Description | fermitin family homolog 3MIG2-like proteinUNC-112 related protein 2kindlin 3unc-112-related protein 2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
FERMT3 | GO:0030335 | positive regulation of cell migration | 19234463 |
FERMT3 | GO:0033622 | integrin activation | 19234463 |
FERMT3 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 19234463 |
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Gene structures and expression levels for FERMT3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FERMT3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_135025 | chr11 | 64220220:64220326:64220436:64220669:64221016:64221140 | 64220436:64220669 |
exon_skip_247055 | chr11 | 64220437:64220669:64221016:64221140:64223048:64223189 | 64221016:64221140 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FERMT3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000279227 | 64221016 | 64221140 | Frame-shift |
ENST00000279227 | 64220436 | 64220669 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000279227 | 64220436 | 64220669 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FERMT3 |
p-ENSG00000149781_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000279227 | 2506 | 667 | 64220436 | 64220669 | 1420 | 1652 | 441 | 519 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000279227 | 2506 | 667 | 64220436 | 64220669 | 1420 | 1652 | 441 | 519 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q86UX7 | 441 | 519 | 429 | 441 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3 |
Q86UX7 | 441 | 519 | 1 | 667 | Chain | ID=PRO_0000219454;Note=Fermitin family homolog 3 |
Q86UX7 | 441 | 519 | 229 | 558 | Domain | Note=FERM |
Q86UX7 | 441 | 519 | 354 | 457 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
Q86UX7 | 441 | 519 | 442 | 456 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3 |
Q86UX7 | 441 | 519 | 465 | 480 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3 |
Q86UX7 | 441 | 519 | 504 | 504 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q86UX7 | 441 | 519 | 472 | 472 | Sequence conflict | Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q86UX7 | 441 | 519 | 480 | 480 | Sequence conflict | Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q86UX7 | 441 | 519 | 429 | 441 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3 |
Q86UX7 | 441 | 519 | 1 | 667 | Chain | ID=PRO_0000219454;Note=Fermitin family homolog 3 |
Q86UX7 | 441 | 519 | 229 | 558 | Domain | Note=FERM |
Q86UX7 | 441 | 519 | 354 | 457 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
Q86UX7 | 441 | 519 | 442 | 456 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3 |
Q86UX7 | 441 | 519 | 465 | 480 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YS3 |
Q86UX7 | 441 | 519 | 504 | 504 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
Q86UX7 | 441 | 519 | 472 | 472 | Sequence conflict | Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q86UX7 | 441 | 519 | 480 | 480 | Sequence conflict | Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in FERMT3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FERMT3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FERMT3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FERMT3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FERMT3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for FERMT3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FERMT3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |