ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for RPS6KL1

Gene summary

Gene information	Gene symbol	RPS6KL1
	Gene ID	83694
	Gene name	ribosomal protein S6 kinase like 1
	Synonyms	RSKL2
	Cytomap	14q24.3
	Type of gene	protein-coding
	Description	ribosomal protein S6 kinase-like 1
	Modification date	20200320
	UniProtAcc	A0A0G2JL89, H0YJ58, H0YJ80, H0YJB8, H0YJM5, H0YJR0, Q9Y6S9,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for RPS6KL1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000198208

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	DOWN	ENST00000555910.5	RPS6KL1-212:protein_coding:RPS6KL1	1.357152e+02	-1.473903e+00	2.372172e-11	1.961637e-09
CB	DOWN	ENST00000553789.5	RPS6KL1-204:protein_coding:RPS6KL1	2.473162e+00	-1.086200e+00	1.329072e-02	4.374656e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RPS6KL1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_126010	chr14	74908850:74908932:74909101:74910148:74911248:74911276	74909101:74910148
exon_skip_193508	chr14	74921516:74921561:74921978:74922442:74923180:74923243	74921978:74922442
exon_skip_228803	chr14	74911794:74911841:74918513:74918605:74919845:74919969	74918513:74918605
exon_skip_238146	chr14	74908850:74908932:74909101:74909190:74909543:74909668	74909101:74909190
exon_skip_249621	chr14	74921516:74921561:74921978:74922485:74923180:74923243	74921978:74922485
exon_skip_256866	chr14	74909101:74909190:74909543:74910148:74911248:74911276	74909543:74910148
exon_skip_267588	chr14	74911794:74911841:74918513:74918605:74919845:74919955	74918513:74918605
exon_skip_2759	chr14	74907018:74907124:74907435:74907530:74908850:74908930	74907435:74907530
exon_skip_290322	chr14	74907018:74907124:74907435:74907530:74908850:74908932	74907435:74907530
exon_skip_54506	chr14	74911353:74911380:74911794:74911841:74918513:74918550	74911794:74911841
exon_skip_65507	chr14	74921516:74921561:74922341:74922485:74923180:74923243	74922341:74922485
exon_skip_65659	chr14	74908850:74908932:74909101:74909161:74909543:74909668	74909101:74909161
exon_skip_73191	chr14	74908850:74908932:74909101:74909190:74911248:74911276	74909101:74909190
exon_skip_78598	chr14	74911353:74911380:74911794:74911841:74919845:74919969	74911794:74911841

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_228803	Mayo_CB	3.343750e-01	5.324658e-01	-1.980908e-01	1.883804e-08

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Open reading frame (ORF) annotation in the exon skipping event for RPS6KL1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000557413	74921978	74922485	3UTR-3UTR
ENST00000555647	74922341	74922485	3UTR-3UTR
ENST00000354625	74907435	74907530	In-frame
ENST00000555647	74907435	74907530	In-frame
ENST00000557413	74907435	74907530	In-frame
ENST00000354625	74909101	74909190	In-frame
ENST00000555647	74909101	74909190	In-frame
ENST00000557413	74909101	74909190	In-frame
ENST00000354625	74909543	74910148	In-frame
ENST00000555647	74909543	74910148	In-frame
ENST00000557413	74909543	74910148	In-frame
ENST00000354625	74911794	74911841	In-frame
ENST00000555647	74911794	74911841	In-frame
ENST00000557413	74911794	74911841	In-frame
ENST00000354625	74918513	74918605	In-frame
ENST00000555647	74918513	74918605	In-frame
ENST00000557413	74918513	74918605	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000557413	74921978	74922485	3UTR-3UTR
ENST00000555647	74922341	74922485	3UTR-3UTR
ENST00000354625	74907435	74907530	In-frame
ENST00000555647	74907435	74907530	In-frame
ENST00000557413	74907435	74907530	In-frame
ENST00000354625	74909101	74909190	In-frame
ENST00000555647	74909101	74909190	In-frame
ENST00000557413	74909101	74909190	In-frame
ENST00000354625	74909543	74910148	In-frame
ENST00000555647	74909543	74910148	In-frame
ENST00000557413	74909543	74910148	In-frame
ENST00000354625	74918513	74918605	In-frame
ENST00000555647	74918513	74918605	In-frame
ENST00000557413	74918513	74918605	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000557413	74921978	74922485	3UTR-3UTR
ENST00000555647	74922341	74922485	3UTR-3UTR
ENST00000354625	74907435	74907530	In-frame
ENST00000555647	74907435	74907530	In-frame
ENST00000557413	74907435	74907530	In-frame
ENST00000354625	74909101	74909190	In-frame
ENST00000555647	74909101	74909190	In-frame
ENST00000557413	74909101	74909190	In-frame
ENST00000354625	74909543	74910148	In-frame
ENST00000555647	74909543	74910148	In-frame
ENST00000557413	74909543	74910148	In-frame
ENST00000354625	74911794	74911841	In-frame
ENST00000555647	74911794	74911841	In-frame
ENST00000557413	74911794	74911841	In-frame
ENST00000354625	74918513	74918605	In-frame
ENST00000555647	74918513	74918605	In-frame
ENST00000557413	74918513	74918605	In-frame

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Infer the effects of exon skipping event on protein functional features for RPS6KL1

p-ENSG00000198208_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000354625	5212	549	74918513	74918605	876	967	130	160
ENST00000555647	3326	549	74918513	74918605	679	770	130	160
ENST00000557413	2442	549	74918513	74918605	1136	1227	130	160
ENST00000354625	5212	549	74911794	74911841	969	1015	161	176
ENST00000555647	3326	549	74911794	74911841	772	818	161	176
ENST00000557413	2442	549	74911794	74911841	1229	1275	161	176
ENST00000354625	5212	549	74909543	74910148	1150	1754	221	423
ENST00000555647	3326	549	74909543	74910148	953	1557	221	423
ENST00000557413	2442	549	74909543	74910148	1410	2014	221	423
ENST00000354625	5212	549	74909101	74909190	1756	1844	423	453
ENST00000555647	3326	549	74909101	74909190	1559	1647	423	453
ENST00000557413	2442	549	74909101	74909190	2016	2104	423	453
ENST00000354625	5212	549	74907435	74907530	1929	2023	481	512
ENST00000555647	3326	549	74907435	74907530	1732	1826	481	512
ENST00000557413	2442	549	74907435	74907530	2189	2283	481	512

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000354625	5212	549	74918513	74918605	876	967	130	160
ENST00000555647	3326	549	74918513	74918605	679	770	130	160
ENST00000557413	2442	549	74918513	74918605	1136	1227	130	160
ENST00000354625	5212	549	74909543	74910148	1150	1754	221	423
ENST00000555647	3326	549	74909543	74910148	953	1557	221	423
ENST00000557413	2442	549	74909543	74910148	1410	2014	221	423
ENST00000354625	5212	549	74909101	74909190	1756	1844	423	453
ENST00000555647	3326	549	74909101	74909190	1559	1647	423	453
ENST00000557413	2442	549	74909101	74909190	2016	2104	423	453
ENST00000354625	5212	549	74907435	74907530	1929	2023	481	512
ENST00000555647	3326	549	74907435	74907530	1732	1826	481	512
ENST00000557413	2442	549	74907435	74907530	2189	2283	481	512

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000354625	5212	549	74918513	74918605	876	967	130	160
ENST00000555647	3326	549	74918513	74918605	679	770	130	160
ENST00000557413	2442	549	74918513	74918605	1136	1227	130	160
ENST00000354625	5212	549	74911794	74911841	969	1015	161	176
ENST00000555647	3326	549	74911794	74911841	772	818	161	176
ENST00000557413	2442	549	74911794	74911841	1229	1275	161	176
ENST00000354625	5212	549	74909543	74910148	1150	1754	221	423
ENST00000555647	3326	549	74909543	74910148	953	1557	221	423
ENST00000557413	2442	549	74909543	74910148	1410	2014	221	423
ENST00000354625	5212	549	74909101	74909190	1756	1844	423	453
ENST00000555647	3326	549	74909101	74909190	1559	1647	423	453
ENST00000557413	2442	549	74909101	74909190	2016	2104	423	453
ENST00000354625	5212	549	74907435	74907530	1929	2023	481	512
ENST00000555647	3326	549	74907435	74907530	1732	1826	481	512
ENST00000557413	2442	549	74907435	74907530	2189	2283	481	512

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	161	176	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	161	176	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	161	176	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	161	176	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	161	176	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	161	176	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	161	176	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	161	176	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	161	176	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	130	160	151	159	Nucleotide binding	Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	161	176	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	161	176	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	161	176	131	161	Alternative sequence	ID=VSP_036440;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9Y6S9	161	176	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	161	176	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	161	176	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	161	176	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	161	176	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	161	176	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	412	412	Active site	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	223	255	Alternative sequence	ID=VSP_017931;Note=In isoform 4. GTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNP->EQAWGPLSAPQAFGVCRQPLKCGALAGRGGSRL;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	221	423	332	332	Natural variant	ID=VAR_041067;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs55871101,PMID:17344846
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	423	453	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	256	549	Alternative sequence	ID=VSP_017932;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	1	549	Chain	ID=PRO_0000232641;Note=Ribosomal protein S6 kinase-like 1
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q9Y6S9	481	512	145	539	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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3'-UTR located exon skipping events that lost miRNA binding sites in RPS6KL1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000555647	74922341	74922485	hsa-miR-6737-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
Mayo	ENST00000557413	74921978	74922485	hsa-miR-6737-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
Mayo	ENST00000555647	74922341	74922485	hsa-miR-5008-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
Mayo	ENST00000557413	74921978	74922485	hsa-miR-5008-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
Mayo	ENST00000557413	74921978	74922485	hsa-miR-1252-3p	chr14:74922332-74922339	8mer-1a	chr14:74922327-74922349	157.00	-17.78
Mayo	ENST00000557413	74921978	74922485	hsa-miR-9902	chr14:74922122-74922129	8mer-1a	chr14:74922110-74922132	163.00	-21.46
Mayo	ENST00000555647	74922341	74922485	hsa-miR-5580-5p	chr14:74922447-74922454	8mer-1a	chr14:74922431-74922456	165.00	-29.52
Mayo	ENST00000557413	74921978	74922485	hsa-miR-5580-5p	chr14:74922447-74922454	8mer-1a	chr14:74922431-74922456	165.00	-29.52
Mayo	ENST00000555647	74922341	74922485	hsa-miR-665	chr14:74922440-74922447	8mer-1a	chr14:74922426-74922453	168.00	-32.81
Mayo	ENST00000557413	74921978	74922485	hsa-miR-665	chr14:74922440-74922447	8mer-1a	chr14:74922426-74922453	168.00	-32.81
Mayo	ENST00000557413	74921978	74922485	hsa-miR-1233-5p	chr14:74922034-74922041	8mer-1a	chr14:74922018-74922041	175.00	-37.02
Mayo	ENST00000557413	74921978	74922485	hsa-miR-6771-3p	chr14:74922346-74922353	8mer-1a	chr14:74922339-74922360	156.00	-23.10
Mayo	ENST00000557413	74921978	74922485	hsa-miR-11401	chr14:74922055-74922062	8mer-1a	chr14:74922054-74922076	143.00	-23.43
Mayo	ENST00000557413	74921978	74922485	hsa-miR-6778-5p	chr14:74922034-74922041	8mer-1a	chr14:74922018-74922041	175.00	-37.02
Mayo	ENST00000557413	74921978	74922485	hsa-miR-7974	chr14:74922180-74922187	8mer-1a	chr14:74922159-74922187	156.00	-22.13
Mayo	ENST00000555647	74922341	74922485	hsa-miR-7157-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
Mayo	ENST00000557413	74921978	74922485	hsa-miR-7157-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
Mayo	ENST00000557413	74921978	74922485	hsa-miR-644a	chr14:74922246-74922253	8mer-1a	chr14:74922241-74922264	150.00	-30.96
Mayo	ENST00000557413	74921978	74922485	hsa-miR-3928-3p	chr14:74922271-74922278	8mer-1a	chr14:74922267-74922292	178.00	-30.20
Mayo	ENST00000555647	74922341	74922485	hsa-miR-6825-3p	chr14:74922422-74922429	8mer-1a	chr14:74922419-74922441	151.00	-26.59
Mayo	ENST00000557413	74921978	74922485	hsa-miR-6825-3p	chr14:74922422-74922429	8mer-1a	chr14:74922419-74922441	151.00	-26.59
Mayo	ENST00000557413	74921978	74922485	hsa-miR-1243	chr14:74922220-74922227	8mer-1a	chr14:74922204-74922227	142.00	-13.82
Mayo	ENST00000555647	74922341	74922485	hsa-miR-3692-5p	chr14:74922449-74922456	8mer-1a	chr14:74922431-74922456	165.00	-29.52
Mayo	ENST00000557413	74921978	74922485	hsa-miR-3692-5p	chr14:74922449-74922456	8mer-1a	chr14:74922431-74922456	165.00	-29.52
Mayo	ENST00000557413	74921978	74922485	hsa-miR-4284	chr14:74922059-74922066	8mer-1a	chr14:74922054-74922076	143.00	-23.43
Mayo	ENST00000555647	74922341	74922485	hsa-miR-600	chr14:74922477-74922484	8mer-1a	chr14:74922462-74922484	157.00	-20.20
Mayo	ENST00000557413	74921978	74922485	hsa-miR-600	chr14:74922477-74922484	8mer-1a	chr14:74922462-74922484	157.00	-20.20
Mayo	ENST00000555647	74922341	74922485	hsa-miR-6856-3p	chr14:74922474-74922481	8mer-1a	chr14:74922462-74922484	157.00	-20.20
Mayo	ENST00000557413	74921978	74922485	hsa-miR-6856-3p	chr14:74922474-74922481	8mer-1a	chr14:74922462-74922484	157.00	-20.20
Mayo	ENST00000557413	74921978	74922485	hsa-miR-188-3p	chr14:74922323-74922330	8mer-1a	chr14:74922311-74922330	149.00	-20.70
MSBB	ENST00000555647	74922341	74922485	hsa-miR-6737-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
MSBB	ENST00000557413	74921978	74922485	hsa-miR-6737-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
MSBB	ENST00000555647	74922341	74922485	hsa-miR-5008-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
MSBB	ENST00000557413	74921978	74922485	hsa-miR-5008-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
MSBB	ENST00000557413	74921978	74922485	hsa-miR-1252-3p	chr14:74922332-74922339	8mer-1a	chr14:74922327-74922349	157.00	-17.78
MSBB	ENST00000557413	74921978	74922485	hsa-miR-9902	chr14:74922122-74922129	8mer-1a	chr14:74922110-74922132	163.00	-21.46
MSBB	ENST00000555647	74922341	74922485	hsa-miR-5580-5p	chr14:74922447-74922454	8mer-1a	chr14:74922431-74922456	165.00	-29.52
MSBB	ENST00000557413	74921978	74922485	hsa-miR-5580-5p	chr14:74922447-74922454	8mer-1a	chr14:74922431-74922456	165.00	-29.52
MSBB	ENST00000555647	74922341	74922485	hsa-miR-665	chr14:74922440-74922447	8mer-1a	chr14:74922426-74922453	168.00	-32.81
MSBB	ENST00000557413	74921978	74922485	hsa-miR-665	chr14:74922440-74922447	8mer-1a	chr14:74922426-74922453	168.00	-32.81
MSBB	ENST00000557413	74921978	74922485	hsa-miR-1233-5p	chr14:74922034-74922041	8mer-1a	chr14:74922018-74922041	175.00	-37.02
MSBB	ENST00000557413	74921978	74922485	hsa-miR-6771-3p	chr14:74922346-74922353	8mer-1a	chr14:74922339-74922360	156.00	-23.10
MSBB	ENST00000557413	74921978	74922485	hsa-miR-11401	chr14:74922055-74922062	8mer-1a	chr14:74922054-74922076	143.00	-23.43
MSBB	ENST00000557413	74921978	74922485	hsa-miR-6778-5p	chr14:74922034-74922041	8mer-1a	chr14:74922018-74922041	175.00	-37.02
MSBB	ENST00000557413	74921978	74922485	hsa-miR-7974	chr14:74922180-74922187	8mer-1a	chr14:74922159-74922187	156.00	-22.13
MSBB	ENST00000555647	74922341	74922485	hsa-miR-7157-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
MSBB	ENST00000557413	74921978	74922485	hsa-miR-7157-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
MSBB	ENST00000557413	74921978	74922485	hsa-miR-644a	chr14:74922246-74922253	8mer-1a	chr14:74922241-74922264	150.00	-30.96
MSBB	ENST00000557413	74921978	74922485	hsa-miR-3928-3p	chr14:74922271-74922278	8mer-1a	chr14:74922267-74922292	178.00	-30.20
MSBB	ENST00000555647	74922341	74922485	hsa-miR-6825-3p	chr14:74922422-74922429	8mer-1a	chr14:74922419-74922441	151.00	-26.59
MSBB	ENST00000557413	74921978	74922485	hsa-miR-6825-3p	chr14:74922422-74922429	8mer-1a	chr14:74922419-74922441	151.00	-26.59
MSBB	ENST00000557413	74921978	74922485	hsa-miR-1243	chr14:74922220-74922227	8mer-1a	chr14:74922204-74922227	142.00	-13.82
MSBB	ENST00000555647	74922341	74922485	hsa-miR-3692-5p	chr14:74922449-74922456	8mer-1a	chr14:74922431-74922456	165.00	-29.52
MSBB	ENST00000557413	74921978	74922485	hsa-miR-3692-5p	chr14:74922449-74922456	8mer-1a	chr14:74922431-74922456	165.00	-29.52
MSBB	ENST00000557413	74921978	74922485	hsa-miR-4284	chr14:74922059-74922066	8mer-1a	chr14:74922054-74922076	143.00	-23.43
MSBB	ENST00000555647	74922341	74922485	hsa-miR-600	chr14:74922477-74922484	8mer-1a	chr14:74922462-74922484	157.00	-20.20
MSBB	ENST00000557413	74921978	74922485	hsa-miR-600	chr14:74922477-74922484	8mer-1a	chr14:74922462-74922484	157.00	-20.20
MSBB	ENST00000555647	74922341	74922485	hsa-miR-6856-3p	chr14:74922474-74922481	8mer-1a	chr14:74922462-74922484	157.00	-20.20
MSBB	ENST00000557413	74921978	74922485	hsa-miR-6856-3p	chr14:74922474-74922481	8mer-1a	chr14:74922462-74922484	157.00	-20.20
MSBB	ENST00000557413	74921978	74922485	hsa-miR-188-3p	chr14:74922323-74922330	8mer-1a	chr14:74922311-74922330	149.00	-20.70
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-6737-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-6737-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-5008-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-5008-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-1252-3p	chr14:74922332-74922339	8mer-1a	chr14:74922327-74922349	157.00	-17.78
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-9902	chr14:74922122-74922129	8mer-1a	chr14:74922110-74922132	163.00	-21.46
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-5580-5p	chr14:74922447-74922454	8mer-1a	chr14:74922431-74922456	165.00	-29.52
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-5580-5p	chr14:74922447-74922454	8mer-1a	chr14:74922431-74922456	165.00	-29.52
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-665	chr14:74922440-74922447	8mer-1a	chr14:74922426-74922453	168.00	-32.81
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-665	chr14:74922440-74922447	8mer-1a	chr14:74922426-74922453	168.00	-32.81
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-1233-5p	chr14:74922034-74922041	8mer-1a	chr14:74922018-74922041	175.00	-37.02
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-6771-3p	chr14:74922346-74922353	8mer-1a	chr14:74922339-74922360	156.00	-23.10
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-11401	chr14:74922055-74922062	8mer-1a	chr14:74922054-74922076	143.00	-23.43
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-6778-5p	chr14:74922034-74922041	8mer-1a	chr14:74922018-74922041	175.00	-37.02
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-7974	chr14:74922180-74922187	8mer-1a	chr14:74922159-74922187	156.00	-22.13
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-7157-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-7157-3p	chr14:74922463-74922470	8mer-1a	chr14:74922460-74922480	163.00	-28.73
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-644a	chr14:74922246-74922253	8mer-1a	chr14:74922241-74922264	150.00	-30.96
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-3928-3p	chr14:74922271-74922278	8mer-1a	chr14:74922267-74922292	178.00	-30.20
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-6825-3p	chr14:74922422-74922429	8mer-1a	chr14:74922419-74922441	151.00	-26.59
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-6825-3p	chr14:74922422-74922429	8mer-1a	chr14:74922419-74922441	151.00	-26.59
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-1243	chr14:74922220-74922227	8mer-1a	chr14:74922204-74922227	142.00	-13.82
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-3692-5p	chr14:74922449-74922456	8mer-1a	chr14:74922431-74922456	165.00	-29.52
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-3692-5p	chr14:74922449-74922456	8mer-1a	chr14:74922431-74922456	165.00	-29.52
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-4284	chr14:74922059-74922066	8mer-1a	chr14:74922054-74922076	143.00	-23.43
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-600	chr14:74922477-74922484	8mer-1a	chr14:74922462-74922484	157.00	-20.20
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-600	chr14:74922477-74922484	8mer-1a	chr14:74922462-74922484	157.00	-20.20
ROSMAP	ENST00000555647	74922341	74922485	hsa-miR-6856-3p	chr14:74922474-74922481	8mer-1a	chr14:74922462-74922484	157.00	-20.20
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-6856-3p	chr14:74922474-74922481	8mer-1a	chr14:74922462-74922484	157.00	-20.20
ROSMAP	ENST00000557413	74921978	74922485	hsa-miR-188-3p	chr14:74922323-74922330	8mer-1a	chr14:74922311-74922330	149.00	-20.70

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SNVs in the skipped exons for RPS6KL1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for RPS6KL1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RPS6KL1

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
HCC	exon_skip_249621	rs10483863	chr14:74855624	3.976201e-04	2.826972e-02
HCC	exon_skip_249621	rs2070599	chr14:74894474	4.676674e-04	3.214956e-02
HCC	exon_skip_249621	rs8014204	chr14:74856091	6.165513e-04	3.994735e-02
HCC	exon_skip_249621	rs2300596	chr14:74887152	6.165513e-04	3.994735e-02
HCC	exon_skip_249621	rs4899536	chr14:74849911	6.575858e-04	4.207814e-02
PCC	exon_skip_249621	rs2159906	chr14:74924209	5.223059e-05	1.027282e-02
PCC	exon_skip_249621	rs175001	chr14:74969749	1.559629e-04	2.459359e-02
PCC	exon_skip_249621	rs175002	chr14:74969763	1.559629e-04	2.459359e-02

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Correlation with RNA binding proteins (RBPs) for RPS6KL1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	HNRNPF	exon_skip_228803	-4.055210e-01	1.992260e-07
CB	RBM4	exon_skip_228803	-7.678191e-01	5.320744e-31
CB	RBM4B	exon_skip_228803	-5.482472e-01	2.209718e-13
TC	RBM4	exon_skip_228803	-4.207559e-01	5.533298e-08

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RelatedDrugs for RPS6KL1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RPS6KL1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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