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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FAM107B |
 Gene summary |
| Gene information | Gene symbol | FAM107B | Gene ID | 83641 |
| Gene name | family with sequence similarity 107 member B | |
| Synonyms | C10orf45|HITS | |
| Cytomap | 10p13 | |
| Type of gene | protein-coding | |
| Description | protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FAM107B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000065809
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| IFG | UP | ENST00000378467.8 | FAM107B-205:protein_coding:FAM107B | 1.578772e+01 | 4.778447e+00 | 5.656959e-06 | 2.001266e-02 |
| CB | UP | ENST00000468747.5 | FAM107B-211:protein_coding:FAM107B | 3.435945e+02 | 1.008626e+00 | 1.185756e-04 | 8.552025e-04 |
| CB | UP | ENST00000489100.5 | FAM107B-223:protein_coding:FAM107B | 5.065018e+00 | 8.868053e-01 | 8.974027e-04 | 4.714087e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FAM107B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_113426 | chr10 | 14530332:14530515:14553322:14553387:14556362:14556414 | 14553322:14553387 |
| exon_skip_142071 | chr10 | 14521945:14522019:14530332:14530515:14571763:14572155 | 14530332:14530515 |
| exon_skip_172380 | chr10 | 14530332:14530515:14553322:14553387:14556016:14556171 | 14553322:14553387 |
| exon_skip_183399 | chr10 | 14530332:14530515:14553322:14553387:14571924:14571999 | 14553322:14553387 |
| exon_skip_235212 | chr10 | 14522002:14522019:14527937:14528039:14530332:14530515 | 14527937:14528039 |
| exon_skip_25729 | chr10 | 14521945:14522019:14530332:14530515:14604240:14604270 | 14530332:14530515 |
| exon_skip_260637 | chr10 | 14530332:14530515:14553322:14553387:14572229:14572314 | 14553322:14553387 |
| exon_skip_261186 | chr10 | 14530332:14530515:14542579:14542686:14553322:14553387 | 14542579:14542686 |
| exon_skip_261372 | chr10 | 14553322:14553387:14556362:14556405:14571924:14572030 | 14556362:14556405 |
| exon_skip_267422 | chr10 | 14521869:14522019:14527937:14528039:14530332:14530515 | 14527937:14528039 |
| exon_skip_27037 | chr10 | 14521869:14522019:14527937:14528039:14530332:14530511 | 14527937:14528039 |
| exon_skip_286531 | chr10 | 14530332:14530515:14553322:14553387:14604240:14604270 | 14553322:14553387 |
| exon_skip_289620 | chr10 | 14553322:14553387:14556362:14556405:14571924:14571999 | 14556362:14556405 |
| exon_skip_31355 | chr10 | 14530332:14530515:14553322:14553387:14571763:14572155 | 14553322:14553387 |
| exon_skip_42197 | chr10 | 14530332:14530515:14553322:14553387:14556362:14556405 | 14553322:14553387 |
| exon_skip_56590 | chr10 | 14522001:14522019:14527937:14528039:14530332:14530511 | 14527937:14528039 |
| exon_skip_97405 | chr10 | 14530332:14530515:14553322:14553387:14571763:14571825 | 14553322:14553387 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for FAM107B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378458 | 14553322 | 14553387 | 3UTR-3UTR |
| ENST00000378467 | 14553322 | 14553387 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378458 | 14553322 | 14553387 | 3UTR-3UTR |
| ENST00000378467 | 14553322 | 14553387 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000468747 | 14530332 | 14530515 | 3UTR-3CDS |
| ENST00000622567 | 14530332 | 14530515 | 3UTR-3CDS |
| ENST00000378458 | 14553322 | 14553387 | 3UTR-3UTR |
| ENST00000378467 | 14553322 | 14553387 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for FAM107B |
p-ENSG00000065809_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FAM107B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000378467 | 14553322 | 14553387 | hsa-miR-376c-5p | chr10:14553357-14553364 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| Mayo | ENST00000378467 | 14553322 | 14553387 | hsa-miR-376b-5p | chr10:14553357-14553364 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| Mayo | ENST00000378467 | 14553322 | 14553387 | hsa-miR-4752 | chr10:14553358-14553365 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| MSBB | ENST00000378467 | 14553322 | 14553387 | hsa-miR-376c-5p | chr10:14553357-14553364 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| MSBB | ENST00000378467 | 14553322 | 14553387 | hsa-miR-376b-5p | chr10:14553357-14553364 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| MSBB | ENST00000378467 | 14553322 | 14553387 | hsa-miR-4752 | chr10:14553358-14553365 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| ROSMAP | ENST00000378467 | 14553322 | 14553387 | hsa-miR-376c-5p | chr10:14553357-14553364 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| ROSMAP | ENST00000378467 | 14553322 | 14553387 | hsa-miR-376b-5p | chr10:14553357-14553364 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
| ROSMAP | ENST00000378467 | 14553322 | 14553387 | hsa-miR-4752 | chr10:14553358-14553365 | 8mer-1a | chr10:14553344-14553365 | 147.00 | -14.53 |
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SNVs in the skipped exons for FAM107B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FAM107B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FAM107B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| TC | exon_skip_286531 | rs11259176 | chr10:14547241 | 8.132991e-05 | 1.385553e-02 |
| TC | exon_skip_286531 | rs11259158 | chr10:14532785 | 2.896511e-04 | 3.798574e-02 |
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Correlation with RNA binding proteins (RBPs) for FAM107B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| HCC | RBM3 | exon_skip_31355 | 4.105822e-01 | 8.296568e-11 |
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RelatedDrugs for FAM107B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM107B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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