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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CASP3 |
 Gene summary |
| Gene information | Gene symbol | CASP3 | Gene ID | 836 |
| Gene name | caspase 3 | |
| Synonyms | CPP32|CPP32B|SCA-1 | |
| Cytomap | 4q35.1 | |
| Type of gene | protein-coding | |
| Description | caspase-3CASP-3CPP-32PARP cleavage proteaseSREBP cleavage activity 1apopaincaspase 3, apoptosis-related cysteine peptidasecaspase 3, apoptosis-related cysteine proteasecysteine protease CPP32procaspase3protein Yama | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CASP3 | GO:0006508 | proteolysis | 12888622|17553422 |
| CASP3 | GO:0030218 | erythrocyte differentiation | 17167422 |
| CASP3 | GO:0031647 | regulation of protein stability | 17553422 |
| CASP3 | GO:0048011 | neurotrophin TRK receptor signaling pathway | 23954828 |
| CASP3 | GO:0097194 | execution phase of apoptosis | 8689682 |
| CASP3 | GO:1902004 | positive regulation of amyloid-beta formation | 17553422 |
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Gene structures and expression levels for CASP3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000164305
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CASP3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_148935 | chr4 | 184638401:184638468:184648465:184648631:184649395:184649447 | 184648465:184648631 |
| exon_skip_155449 | chr4 | 184629384:184629501:184631037:184631157:184631765:184631785 | 184631037:184631157 |
| exon_skip_176528 | chr4 | 184632268:184632396:184635294:184635418:184638401:184638468 | 184635294:184635418 |
| exon_skip_201088 | chr4 | 184629384:184629501:184631037:184631157:184631765:184631940 | 184631037:184631157 |
| exon_skip_247854 | chr4 | 184638401:184638468:184648503:184648631:184649395:184649447 | 184648503:184648631 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CASP3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308394 | 184648465 | 184648631 | 3UTR-3UTR |
| ENST00000308394 | 184631037 | 184631157 | Frame-shift |
| ENST00000523916 | 184631037 | 184631157 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308394 | 184648465 | 184648631 | 3UTR-3UTR |
| ENST00000308394 | 184631037 | 184631157 | Frame-shift |
| ENST00000523916 | 184631037 | 184631157 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308394 | 184648465 | 184648631 | 3UTR-3UTR |
| ENST00000308394 | 184631037 | 184631157 | Frame-shift |
| ENST00000523916 | 184631037 | 184631157 | Frame-shift |
| ENST00000308394 | 184635294 | 184635418 | Frame-shift |
| ENST00000523916 | 184635294 | 184635418 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CASP3 |
p-ENSG00000164305_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CASP3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000308394 | 184648465 | 184648631 | hsa-miR-132-5p | chr4:184648584-184648591 | 8mer-1a | chr4:184648581-184648604 | 152.00 | -26.55 |
| Mayo | ENST00000308394 | 184648465 | 184648631 | hsa-miR-6786-5p | chr4:184648498-184648505 | 8mer-1a | chr4:184648497-184648522 | 150.00 | -28.25 |
| Mayo | ENST00000308394 | 184648465 | 184648631 | hsa-miR-7974 | chr4:184648594-184648601 | 8mer-1a | chr4:184648581-184648604 | 152.00 | -26.55 |
| Mayo | ENST00000308394 | 184648465 | 184648631 | hsa-miR-6804-3p | chr4:184648483-184648490 | 8mer-1a | chr4:184648468-184648490 | 178.00 | -33.82 |
| Mayo | ENST00000308394 | 184648465 | 184648631 | hsa-miR-4455 | chr4:184648494-184648501 | 8mer-1a | chr4:184648493-184648513 | 151.00 | -20.05 |
| Mayo | ENST00000308394 | 184648465 | 184648631 | hsa-miR-29b-1-5p | chr4:184648506-184648513 | 8mer-1a | chr4:184648497-184648522 | 150.00 | -28.25 |
| MSBB | ENST00000308394 | 184648465 | 184648631 | hsa-miR-132-5p | chr4:184648584-184648591 | 8mer-1a | chr4:184648581-184648604 | 152.00 | -26.55 |
| MSBB | ENST00000308394 | 184648465 | 184648631 | hsa-miR-6786-5p | chr4:184648498-184648505 | 8mer-1a | chr4:184648497-184648522 | 150.00 | -28.25 |
| MSBB | ENST00000308394 | 184648465 | 184648631 | hsa-miR-7974 | chr4:184648594-184648601 | 8mer-1a | chr4:184648581-184648604 | 152.00 | -26.55 |
| MSBB | ENST00000308394 | 184648465 | 184648631 | hsa-miR-6804-3p | chr4:184648483-184648490 | 8mer-1a | chr4:184648468-184648490 | 178.00 | -33.82 |
| MSBB | ENST00000308394 | 184648465 | 184648631 | hsa-miR-4455 | chr4:184648494-184648501 | 8mer-1a | chr4:184648493-184648513 | 151.00 | -20.05 |
| MSBB | ENST00000308394 | 184648465 | 184648631 | hsa-miR-29b-1-5p | chr4:184648506-184648513 | 8mer-1a | chr4:184648497-184648522 | 150.00 | -28.25 |
| ROSMAP | ENST00000308394 | 184648465 | 184648631 | hsa-miR-132-5p | chr4:184648584-184648591 | 8mer-1a | chr4:184648581-184648604 | 152.00 | -26.55 |
| ROSMAP | ENST00000308394 | 184648465 | 184648631 | hsa-miR-6786-5p | chr4:184648498-184648505 | 8mer-1a | chr4:184648497-184648522 | 150.00 | -28.25 |
| ROSMAP | ENST00000308394 | 184648465 | 184648631 | hsa-miR-7974 | chr4:184648594-184648601 | 8mer-1a | chr4:184648581-184648604 | 152.00 | -26.55 |
| ROSMAP | ENST00000308394 | 184648465 | 184648631 | hsa-miR-6804-3p | chr4:184648483-184648490 | 8mer-1a | chr4:184648468-184648490 | 178.00 | -33.82 |
| ROSMAP | ENST00000308394 | 184648465 | 184648631 | hsa-miR-4455 | chr4:184648494-184648501 | 8mer-1a | chr4:184648493-184648513 | 151.00 | -20.05 |
| ROSMAP | ENST00000308394 | 184648465 | 184648631 | hsa-miR-29b-1-5p | chr4:184648506-184648513 | 8mer-1a | chr4:184648497-184648522 | 150.00 | -28.25 |
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SNVs in the skipped exons for CASP3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CASP3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CASP3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CASP3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CASP3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P42574 | approved|investigational | DB01017 | Minocycline | small molecule | P42574 |
| P42574 | approved|experimental | DB13751 | Glycyrrhizic acid | small molecule | P42574 |
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RelatedDiseases for CASP3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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