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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for PICALM |
 Gene summary |
| Gene information | Gene symbol | PICALM | Gene ID | 8301 |
| Gene name | phosphatidylinositol binding clathrin assembly protein | |
| Synonyms | CALM|CLTH|LAP | |
| Cytomap | 11q14.2 | |
| Type of gene | protein-coding | |
| Description | phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein | |
| Modification date | 20200322 | |
| UniProtAcc | A0A024R5L7, A0A024R5P1, | |
| Context | - 26005850(Central Role for PICALM in amyloid-β Blood-Brain Barrier Transcytosis and Clearance) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PICALM | GO:0006897 | endocytosis | 22118466 |
| PICALM | GO:0006898 | receptor-mediated endocytosis | 10436022 |
| PICALM | GO:0032880 | regulation of protein localization | 10436022 |
| PICALM | GO:0045893 | positive regulation of transcription, DNA-templated | 11425879 |
| PICALM | GO:0048261 | negative regulation of receptor-mediated endocytosis | 10436022 |
| PICALM | GO:1905224 | clathrin-coated pit assembly | 16262731 |
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Gene structures and expression levels for PICALM |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000073921
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000532603.5 | PICALM-220:protein_coding:PICALM | 4.102124e+00 | 1.043312e+00 | 2.901014e-04 | 1.170230e-02 |
| PG | UP | ENST00000529760.5 | PICALM-212:protein_coding:PICALM | 4.929424e+01 | 1.997903e+00 | 2.238916e-05 | 9.082268e-04 |
| CB | UP | ENST00000532603.5 | PICALM-220:protein_coding:PICALM | 3.799393e+01 | 1.366562e+00 | 1.533132e-14 | 4.948614e-12 |
| CB | UP | ENST00000529016.5 | PICALM-211:protein_coding:PICALM | 6.219025e+00 | 1.096644e+00 | 2.046198e-05 | 1.929332e-04 |
| CB | UP | ENST00000356360.9 | PICALM-201:protein_coding:PICALM | 5.173711e+00 | 1.562215e+00 | 8.988601e-05 | 6.769406e-04 |
| CB | UP | ENST00000530542.1 | PICALM-213:protein_coding:PICALM | 5.791993e+01 | 8.736033e-01 | 4.203344e-04 | 2.488089e-03 |
| CB | UP | ENST00000532041.5 | PICALM-218:nonsense_mediated_decay:PICALM | 2.277999e+00 | 1.002120e+00 | 5.432377e-04 | 3.090411e-03 |
| TC | UP | ENST00000532603.5 | PICALM-220:protein_coding:PICALM | 2.803032e+01 | 9.393856e-01 | 1.942047e-09 | 2.275471e-07 |
| TC | UP | ENST00000532041.5 | PICALM-218:nonsense_mediated_decay:PICALM | 2.511909e+00 | 9.343736e-01 | 7.705561e-05 | 1.312952e-03 |
| TC | UP | ENST00000528256.1 | PICALM-208:protein_coding:PICALM | 3.564965e+00 | 8.755810e-01 | 2.744252e-03 | 2.130897e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PICALM |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101144 | chr11 | 85959037:85959060:85960675:85960777:85974708:85974809 | 85960675:85960777 |
| exon_skip_134548 | chr11 | 85981872:85981988:85983866:85983973:85996826:85996929 | 85983866:85983973 |
| exon_skip_13956 | chr11 | 85983866:85983973:85990250:85990378:85996826:85996892 | 85990250:85990378 |
| exon_skip_182383 | chr11 | 86012343:86012392:86014870:86014963:86022367:86022469 | 86014870:86014963 |
| exon_skip_194281 | chr11 | 85974782:85974812:85976623:85976682:85981129:85981228 | 85976623:85976682 |
| exon_skip_197200 | chr11 | 85983926:85983973:85990250:85990399:85996826:85996929 | 85990250:85990399 |
| exon_skip_204806 | chr11 | 85981872:85982003:85983866:85983973:85990250:85990258 | 85983866:85983973 |
| exon_skip_21261 | chr11 | 85981872:85982003:85983866:85983973:85996826:85996929 | 85983866:85983973 |
| exon_skip_219539 | chr11 | 86022449:86022469:86026292:86026367:86031469:86031611 | 86026292:86026367 |
| exon_skip_222187 | chr11 | 85959037:85959060:85981129:85981228:85981745:85981775 | 85981129:85981228 |
| exon_skip_224206 | chr11 | 86022378:86022469:86026292:86026367:86031469:86031611 | 86026292:86026367 |
| exon_skip_227437 | chr11 | 86007542:86007583:86011030:86011136:86012281:86012392 | 86011030:86011136 |
| exon_skip_230 | chr11 | 85996826:85996929:86000643:86000779:86001035:86001141 | 86000643:86000779 |
| exon_skip_232623 | chr11 | 85959037:85959060:85974708:85974812:85981129:85981228 | 85974708:85974812 |
| exon_skip_23368 | chr11 | 85983926:85983973:85990250:85990378:85996826:85996929 | 85990250:85990378 |
| exon_skip_235587 | chr11 | 85959037:85959060:85960675:85960777:85974708:85974795 | 85960675:85960777 |
| exon_skip_236258 | chr11 | 85981872:85981988:85983866:85983973:85990250:85990258 | 85983866:85983973 |
| exon_skip_240941 | chr11 | 85974782:85974812:85981129:85981228:85981745:85981775 | 85981129:85981228 |
| exon_skip_244953 | chr11 | 85983866:85983973:85996826:85996929:86000643:86000779 | 85996826:85996929 |
| exon_skip_246982 | chr11 | 85976649:85976682:85978070:85978093:85981129:85981228 | 85978070:85978093 |
| exon_skip_247779 | chr11 | 86003366:86003451:86007542:86007583:86011030:86011134 | 86007542:86007583 |
| exon_skip_247821 | chr11 | 86026292:86026367:86031469:86031611:86068651:86068733 | 86031469:86031611 |
| exon_skip_248937 | chr11 | 86014870:86014963:86022367:86022469:86026292:86026367 | 86022367:86022469 |
| exon_skip_253304 | chr11 | 86031469:86031611:86068651:86068733:86069720:86069811 | 86068651:86068733 |
| exon_skip_255821 | chr11 | 86022378:86022469:86031469:86031611:86068651:86068733 | 86031469:86031611 |
| exon_skip_270345 | chr11 | 85983866:85983973:85990250:85990399:85996826:85996892 | 85990250:85990399 |
| exon_skip_271658 | chr11 | 85996842:85996929:86000643:86000779:86001035:86001141 | 86000643:86000779 |
| exon_skip_27213 | chr11 | 85974782:85974812:85976623:85976682:85978070:85978093 | 85976623:85976682 |
| exon_skip_283760 | chr11 | 85959037:85959060:85974708:85974812:85976623:85976682 | 85974708:85974812 |
| exon_skip_39865 | chr11 | 85959037:85959060:85974708:85974812:85981129:85981226 | 85974708:85974812 |
| exon_skip_45284 | chr11 | 85974782:85974812:85976623:85976682:85981129:85981226 | 85976623:85976682 |
| exon_skip_53611 | chr11 | 85959037:85959060:85960675:85960777:85974708:85974812 | 85960675:85960777 |
| exon_skip_64034 | chr11 | 86026354:86026367:86031469:86031611:86068651:86068733 | 86031469:86031611 |
| exon_skip_68160 | chr11 | 86022449:86022469:86023416:86023541:86026292:86026367 | 86023416:86023541 |
| exon_skip_73544 | chr11 | 86022378:86022469:86023416:86023541:86026292:86026367 | 86023416:86023541 |
| exon_skip_79926 | chr11 | 86022378:86022469:86023416:86023541:86026292:86026332 | 86023416:86023541 |
| exon_skip_85936 | chr11 | 86014870:86014963:86022367:86022469:86031469:86031611 | 86022367:86022469 |
| exon_skip_87980 | chr11 | 85983866:85983973:85990250:85990378:85996826:85996929 | 85990250:85990378 |
| exon_skip_92613 | chr11 | 85983866:85983973:85990250:85990399:85996826:85996929 | 85990250:85990399 |
| exon_skip_97223 | chr11 | 85976649:85976682:85978070:85978093:85981129:85981225 | 85978070:85978093 |
| exon_skip_98441 | chr11 | 86003366:86003451:86007542:86007583:86011030:86011136 | 86007542:86007583 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_270345 | MSBB_PG | 2.621854e-01 | 3.937931e-01 | -1.316077e-01 | 2.965425e-07 |
| exon_skip_194281 | Mayo_CB | 6.881707e-01 | 8.250000e-01 | -1.368293e-01 | 3.655802e-07 |
| exon_skip_289462 | Mayo_CB | 6.681707e-01 | 7.890667e-01 | -1.208959e-01 | 1.937269e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for PICALM |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393346 | 86000643 | 86000779 | Frame-shift |
| ENST00000393346 | 86011030 | 86011136 | Frame-shift |
| ENST00000393346 | 86014870 | 86014963 | Frame-shift |
| ENST00000393346 | 86022367 | 86022469 | Frame-shift |
| ENST00000393346 | 86026292 | 86026367 | Frame-shift |
| ENST00000393346 | 85974708 | 85974812 | In-frame |
| ENST00000393346 | 85976623 | 85976682 | In-frame |
| ENST00000393346 | 85990250 | 85990399 | In-frame |
| ENST00000393346 | 86007542 | 86007583 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393346 | 86000643 | 86000779 | Frame-shift |
| ENST00000393346 | 86011030 | 86011136 | Frame-shift |
| ENST00000393346 | 86022367 | 86022469 | Frame-shift |
| ENST00000393346 | 86026292 | 86026367 | Frame-shift |
| ENST00000393346 | 85974708 | 85974812 | In-frame |
| ENST00000393346 | 85976623 | 85976682 | In-frame |
| ENST00000393346 | 85990250 | 85990399 | In-frame |
| ENST00000393346 | 86007542 | 86007583 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393346 | 86000643 | 86000779 | Frame-shift |
| ENST00000393346 | 86011030 | 86011136 | Frame-shift |
| ENST00000393346 | 86022367 | 86022469 | Frame-shift |
| ENST00000393346 | 86026292 | 86026367 | Frame-shift |
| ENST00000393346 | 85974708 | 85974812 | In-frame |
| ENST00000393346 | 85976623 | 85976682 | In-frame |
| ENST00000393346 | 85983866 | 85983973 | In-frame |
| ENST00000393346 | 85990250 | 85990399 | In-frame |
| ENST00000393346 | 86007542 | 86007583 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PICALM |
p-ENSG00000073921_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000393346 | 2357 | 652 | 86007542 | 86007583 | 915 | 955 | 255 | 268 |
| ENST00000393346 | 2357 | 652 | 85990250 | 85990399 | 1408 | 1556 | 419 | 469 |
| ENST00000393346 | 2357 | 652 | 85976623 | 85976682 | 1929 | 1987 | 593 | 612 |
| ENST00000393346 | 2357 | 652 | 85974708 | 85974812 | 1989 | 2092 | 613 | 647 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000393346 | 2357 | 652 | 86007542 | 86007583 | 915 | 955 | 255 | 268 |
| ENST00000393346 | 2357 | 652 | 85990250 | 85990399 | 1408 | 1556 | 419 | 469 |
| ENST00000393346 | 2357 | 652 | 85976623 | 85976682 | 1929 | 1987 | 593 | 612 |
| ENST00000393346 | 2357 | 652 | 85974708 | 85974812 | 1989 | 2092 | 613 | 647 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000393346 | 2357 | 652 | 86007542 | 86007583 | 915 | 955 | 255 | 268 |
| ENST00000393346 | 2357 | 652 | 85990250 | 85990399 | 1408 | 1556 | 419 | 469 |
| ENST00000393346 | 2357 | 652 | 85983866 | 85983973 | 1558 | 1664 | 469 | 505 |
| ENST00000393346 | 2357 | 652 | 85976623 | 85976682 | 1929 | 1987 | 593 | 612 |
| ENST00000393346 | 2357 | 652 | 85974708 | 85974812 | 1989 | 2092 | 613 | 647 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13492 | 255 | 268 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 255 | 268 | 221 | 294 | Region | Note=Interaction with PIMREG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16491119;Dbxref=PMID:16491119 |
| Q13492 | 419 | 469 | 420 | 469 | Alternative sequence | ID=VSP_009607;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q13492 | 419 | 469 | 420 | 426 | Alternative sequence | ID=VSP_044568;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| Q13492 | 419 | 469 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 593 | 612 | 593 | 593 | Alternative sequence | ID=VSP_009608;Note=In isoform 3. M->MNGMHFPQY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13492 | 593 | 612 | 594 | 613 | Alternative sequence | ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689 |
| Q13492 | 593 | 612 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 613 | 647 | 594 | 613 | Alternative sequence | ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689 |
| Q13492 | 613 | 647 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 613 | 647 | 641 | 641 | Natural variant | ID=VAR_028195;Note=F->L;Dbxref=dbSNP:rs556337 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13492 | 255 | 268 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 255 | 268 | 221 | 294 | Region | Note=Interaction with PIMREG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16491119;Dbxref=PMID:16491119 |
| Q13492 | 419 | 469 | 420 | 469 | Alternative sequence | ID=VSP_009607;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q13492 | 419 | 469 | 420 | 426 | Alternative sequence | ID=VSP_044568;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| Q13492 | 419 | 469 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 593 | 612 | 593 | 593 | Alternative sequence | ID=VSP_009608;Note=In isoform 3. M->MNGMHFPQY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13492 | 593 | 612 | 594 | 613 | Alternative sequence | ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689 |
| Q13492 | 593 | 612 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 613 | 647 | 594 | 613 | Alternative sequence | ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689 |
| Q13492 | 613 | 647 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 613 | 647 | 641 | 641 | Natural variant | ID=VAR_028195;Note=F->L;Dbxref=dbSNP:rs556337 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13492 | 255 | 268 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 255 | 268 | 221 | 294 | Region | Note=Interaction with PIMREG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16491119;Dbxref=PMID:16491119 |
| Q13492 | 419 | 469 | 420 | 469 | Alternative sequence | ID=VSP_009607;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q13492 | 419 | 469 | 420 | 426 | Alternative sequence | ID=VSP_044568;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.3 |
| Q13492 | 419 | 469 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 469 | 505 | 420 | 469 | Alternative sequence | ID=VSP_009607;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
| Q13492 | 469 | 505 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 593 | 612 | 593 | 593 | Alternative sequence | ID=VSP_009608;Note=In isoform 3. M->MNGMHFPQY;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q13492 | 593 | 612 | 594 | 613 | Alternative sequence | ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689 |
| Q13492 | 593 | 612 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 613 | 647 | 594 | 613 | Alternative sequence | ID=VSP_004067;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9737689;Dbxref=PMID:9737689 |
| Q13492 | 613 | 647 | 2 | 652 | Chain | ID=PRO_0000187062;Note=Phosphatidylinositol-binding clathrin assembly protein |
| Q13492 | 613 | 647 | 641 | 641 | Natural variant | ID=VAR_028195;Note=F->L;Dbxref=dbSNP:rs556337 |
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3'-UTR located exon skipping events that lost miRNA binding sites in PICALM |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for PICALM |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for PICALM |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | PG | exon_skip_270345 | -4.085020e-01 | 8.240000e-10 | chr11 | - | 85983866 | 85983973 | 85990250 | 85990399 | 85996826 | 85996892 |
| ADstage | ROSMAP | PCC | exon_skip_53611 | -3.222845e-01 | 1.380000e-06 | chr11 | - | 85959037 | 85959060 | 85960675 | 85960777 | 85974708 | 85974812 |
| CDR | MSBB | PG | exon_skip_270345 | -4.189230e-01 | 2.740000e-10 | chr11 | - | 85983866 | 85983973 | 85990250 | 85990399 | 85996826 | 85996892 |
| CDR | MSBB | PG | exon_skip_13956 | -3.438040e-01 | 3.460000e-07 | chr11 | - | 85983866 | 85983973 | 85990250 | 85990378 | 85996826 | 85996892 |
| CDR | MSBB | STG | exon_skip_53611 | -3.414736e-01 | 8.086900e-04 | chr11 | - | 85959037 | 85959060 | 85960675 | 85960777 | 85974708 | 85974812 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PICALM |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for PICALM |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | PCBP4 | exon_skip_101144 | 4.659635e-01 | 6.033701e-10 |
| CB | NUP42 | exon_skip_101144 | 5.817191e-01 | 8.918504e-16 |
| CB | RALYL | exon_skip_101144 | 4.308503e-01 | 1.435942e-08 |
| CB | DAZAP1 | exon_skip_194281 | -4.073509e-01 | 1.085039e-07 |
| CB | RBM6 | exon_skip_194281 | -5.721978e-01 | 4.038088e-15 |
| CB | RBM45 | exon_skip_194281 | 6.771869e-01 | 1.535780e-22 |
| CB | NUP42 | exon_skip_194281 | 5.007495e-01 | 2.080090e-11 |
| CB | DAZAP1 | exon_skip_289462 | -4.089334e-01 | 1.052982e-07 |
| CB | TARDBP | exon_skip_289462 | -4.168939e-01 | 5.595544e-08 |
| CB | RBM6 | exon_skip_289462 | -5.445306e-01 | 1.682816e-13 |
| CB | U2AF2 | exon_skip_289462 | -6.075377e-01 | 3.271315e-17 |
| CB | CNOT4 | exon_skip_289462 | -4.623721e-01 | 1.085835e-09 |
| CB | RBM3 | exon_skip_289462 | 4.949191e-01 | 4.433359e-11 |
| CB | FUBP1 | exon_skip_289462 | -4.792852e-01 | 2.148639e-10 |
| CB | RBM45 | exon_skip_289462 | 6.648760e-01 | 2.189951e-21 |
| CB | NUP42 | exon_skip_289462 | 4.386331e-01 | 9.136898e-09 |
| CB | PTBP1 | exon_skip_289462 | -4.087258e-01 | 1.070247e-07 |
| CB | RBM45 | exon_skip_89363 | 6.229984e-01 | 9.141506e-16 |
| CB | PTBP1 | exon_skip_89363 | -4.633733e-01 | 1.720136e-08 |
| CB | TIA1 | exon_skip_87980 | 4.041326e-01 | 1.839457e-07 |
| CB | NUP42 | exon_skip_87980 | 5.210800e-01 | 3.626685e-12 |
| CB | RALYL | exon_skip_87980 | 4.132036e-01 | 9.119765e-08 |
| CB | PABPC1 | exon_skip_87980 | 4.056165e-01 | 1.642323e-07 |
| CB | TIA1 | exon_skip_92613 | 5.888663e-01 | 4.999772e-16 |
| CB | HNRNPK | exon_skip_92613 | 5.224098e-01 | 2.259277e-12 |
| CB | PCBP2 | exon_skip_92613 | 5.267832e-01 | 1.372213e-12 |
| CB | HNRNPA0 | exon_skip_92613 | 5.813620e-01 | 1.424909e-15 |
| CB | PUF60 | exon_skip_92613 | 4.014660e-01 | 1.877511e-07 |
| CB | NUP42 | exon_skip_92613 | 6.518204e-01 | 2.345052e-20 |
| CB | RALYL | exon_skip_92613 | 6.839362e-01 | 5.504894e-23 |
| CB | PTBP3 | exon_skip_92613 | 4.487588e-01 | 3.757322e-09 |
| CB | PABPC1 | exon_skip_92613 | 6.108439e-01 | 1.980859e-17 |
| CB | SART3 | exon_skip_92613 | 4.277176e-01 | 2.306276e-08 |
| DLPFC | DAZAP1 | exon_skip_235587 | 5.483425e-01 | 2.558311e-20 |
| DLPFC | SRSF2 | exon_skip_235587 | 5.879166e-01 | 8.496704e-24 |
| DLPFC | CNOT4 | exon_skip_235587 | 5.168968e-01 | 7.262526e-18 |
| DLPFC | PCBP1 | exon_skip_235587 | 6.103123e-01 | 5.497359e-26 |
| DLPFC | HNRNPK | exon_skip_235587 | 5.530923e-01 | 1.034189e-20 |
| DLPFC | UNK | exon_skip_235587 | 5.078310e-01 | 3.329056e-17 |
| DLPFC | PCBP2 | exon_skip_235587 | 5.548447e-01 | 7.377069e-21 |
| DLPFC | KHDRBS2 | exon_skip_235587 | 7.356105e-01 | 2.611285e-42 |
| DLPFC | KHDRBS3 | exon_skip_235587 | 6.755253e-01 | 1.789303e-33 |
| DLPFC | HNRNPD | exon_skip_235587 | 6.249699e-01 | 1.623956e-27 |
| DLPFC | NUP42 | exon_skip_235587 | 5.702225e-01 | 3.487864e-22 |
| DLPFC | RALYL | exon_skip_235587 | 6.688640e-01 | 1.272977e-32 |
| DLPFC | SRSF1 | exon_skip_235587 | 5.526944e-01 | 1.116325e-20 |
| DLPFC | SRSF9 | exon_skip_235587 | 5.531728e-01 | 1.018292e-20 |
| DLPFC | SRSF5 | exon_skip_235587 | 5.640921e-01 | 1.199980e-21 |
| DLPFC | RBM3 | exon_skip_289462 | 4.363131e-01 | 4.770372e-17 |
| DLPFC | PTBP3 | exon_skip_92613 | 4.359439e-01 | 7.823038e-17 |
| FL | SRSF2 | exon_skip_53611 | 4.224048e-01 | 5.692984e-10 |
| FL | HNRNPK | exon_skip_53611 | 4.101035e-01 | 1.971268e-09 |
| FL | KHDRBS3 | exon_skip_53611 | 4.141004e-01 | 1.323934e-09 |
| FL | RALYL | exon_skip_53611 | 4.601255e-01 | 9.109526e-12 |
| FL | RBM3 | exon_skip_289462 | 4.329008e-01 | 2.107251e-10 |
| FL | MSI1 | exon_skip_92613 | -4.912342e-01 | 2.011745e-13 |
| FL | ILF2 | exon_skip_92613 | 5.050671e-01 | 3.248913e-14 |
| FL | HNRNPK | exon_skip_92613 | 4.627676e-01 | 6.687520e-12 |
| FL | KHDRBS3 | exon_skip_92613 | 5.624098e-01 | 6.563198e-18 |
| FL | HNRNPA0 | exon_skip_92613 | 5.400163e-01 | 2.207593e-16 |
| FL | PUF60 | exon_skip_92613 | 4.101257e-01 | 1.966937e-09 |
| FL | RALYL | exon_skip_92613 | 5.844958e-01 | 1.563387e-19 |
| FL | PTBP1 | exon_skip_92613 | -4.254252e-01 | 4.164229e-10 |
| FL | ESRP1 | exon_skip_92613 | 4.637319e-01 | 5.970133e-12 |
| HCC | DAZAP1 | exon_skip_53611 | -4.975998e-01 | 1.745205e-18 |
| HCC | RBMS2 | exon_skip_53611 | -6.059981e-01 | 9.297215e-29 |
| HCC | RBM6 | exon_skip_53611 | -5.509653e-01 | 4.475760e-23 |
| HCC | UNK | exon_skip_53611 | -4.591647e-01 | 1.212749e-15 |
| HCC | PCBP2 | exon_skip_53611 | -4.026577e-01 | 4.596845e-12 |
| HCC | KHDRBS3 | exon_skip_53611 | -4.036751e-01 | 4.015705e-12 |
| HCC | RBM3 | exon_skip_289462 | 5.675115e-01 | 1.130835e-24 |
| HCC | MSI1 | exon_skip_92613 | -6.974585e-01 | 4.207533e-41 |
| HCC | RBM6 | exon_skip_92613 | -7.078874e-01 | 8.199968e-43 |
| HCC | TIA1 | exon_skip_92613 | -5.805433e-01 | 5.376780e-26 |
| HCC | TRNAU1AP | exon_skip_92613 | -5.428696e-01 | 2.515800e-22 |
| HCC | PCBP1 | exon_skip_92613 | -4.703272e-01 | 1.971789e-16 |
| HCC | PCBP4 | exon_skip_92613 | -5.232455e-01 | 1.369281e-20 |
| HCC | PCBP2 | exon_skip_92613 | -4.193695e-01 | 4.706101e-13 |
| HCC | KHDRBS3 | exon_skip_92613 | -5.928555e-01 | 2.660995e-27 |
| HCC | FUBP1 | exon_skip_92613 | -5.296941e-01 | 3.788873e-21 |
| HCC | PTBP1 | exon_skip_92613 | -8.032220e-01 | 6.424490e-63 |
| HCC | PABPC5 | exon_skip_92613 | -4.333260e-01 | 6.353534e-14 |
| HCC | PABPC1 | exon_skip_92613 | -5.085226e-01 | 2.327039e-19 |
| HCC | RBM41 | exon_skip_92613 | -5.089542e-01 | 2.145721e-19 |
| HCC | HNRNPF | exon_skip_92613 | -7.092885e-01 | 4.767383e-43 |
| IFG | RBM47 | exon_skip_53611 | -4.661649e-01 | 1.240770e-02 |
| IFG | MSI1 | exon_skip_194281 | -4.181781e-01 | 2.679403e-02 |
| IFG | KHDRBS3 | exon_skip_87980 | 4.832214e-01 | 9.191078e-03 |
| IFG | HNRNPA0 | exon_skip_87980 | 4.428418e-01 | 1.827617e-02 |
| IFG | NUP42 | exon_skip_87980 | 5.316536e-01 | 3.596067e-03 |
| IFG | RALYL | exon_skip_87980 | 5.954961e-01 | 8.282684e-04 |
| IFG | ESRP1 | exon_skip_87980 | 4.720430e-01 | 1.120727e-02 |
| IFG | ILF2 | exon_skip_92613 | 4.648491e-01 | 1.269057e-02 |
| IFG | KHDRBS3 | exon_skip_92613 | 6.293004e-01 | 3.338128e-04 |
| IFG | HNRNPA0 | exon_skip_92613 | 4.401153e-01 | 1.909097e-02 |
| IFG | NUP42 | exon_skip_92613 | 4.730717e-01 | 1.100751e-02 |
| IFG | RALYL | exon_skip_92613 | 6.320413e-01 | 3.086609e-04 |
| IFG | PTBP1 | exon_skip_92613 | -4.879391e-01 | 8.436653e-03 |
| IFG | ESRP1 | exon_skip_92613 | 4.509084e-01 | 1.603149e-02 |
| PCC | RBMS2 | exon_skip_53611 | -6.394322e-01 | 4.097696e-26 |
| PCC | RBM6 | exon_skip_53611 | -4.468638e-01 | 5.976891e-12 |
| PCC | RALYL | exon_skip_53611 | 4.618592e-01 | 9.298819e-13 |
| PCC | RBM3 | exon_skip_289462 | 5.218571e-01 | 2.042494e-16 |
| PCC | RBM6 | exon_skip_23368 | -5.059932e-01 | 2.590219e-15 |
| PCC | TRNAU1AP | exon_skip_23368 | -4.627091e-01 | 9.435051e-13 |
| PCC | PCBP4 | exon_skip_23368 | -4.340220e-01 | 3.048395e-11 |
| PCC | PTBP1 | exon_skip_23368 | -6.939207e-01 | 4.527542e-32 |
| PCC | PABPC1 | exon_skip_23368 | -4.992401e-01 | 6.872477e-15 |
| PCC | HNRNPF | exon_skip_23368 | -6.012367e-01 | 2.012778e-22 |
| PCC | MSI1 | exon_skip_197200 | -4.732302e-01 | 2.426141e-13 |
| PCC | RBM6 | exon_skip_197200 | -5.239661e-01 | 1.732800e-16 |
| PCC | TRNAU1AP | exon_skip_197200 | -4.191094e-01 | 1.638938e-10 |
| PCC | PCBP4 | exon_skip_197200 | -4.760470e-01 | 1.673197e-13 |
| PCC | RALYL | exon_skip_197200 | 4.942612e-01 | 1.391983e-14 |
| PCC | PTBP1 | exon_skip_197200 | -7.611495e-01 | 9.797209e-42 |
| PCC | PABPC1 | exon_skip_197200 | -5.270716e-01 | 1.068243e-16 |
| PCC | HNRNPF | exon_skip_197200 | -6.415660e-01 | 3.257760e-26 |
| PG | RBMS2 | exon_skip_53611 | -4.211531e-01 | 2.381842e-10 |
| PG | PCBP1 | exon_skip_53611 | 4.964497e-01 | 2.422421e-14 |
| PG | RALYL | exon_skip_53611 | 4.202393e-01 | 2.627830e-10 |
| STG | SRSF2 | exon_skip_53611 | 4.586061e-01 | 3.782280e-06 |
| STG | HNRNPK | exon_skip_53611 | 4.384962e-01 | 1.101132e-05 |
| STG | KHDRBS2 | exon_skip_53611 | 4.854065e-01 | 8.159703e-07 |
| STG | KHDRBS3 | exon_skip_53611 | 4.838138e-01 | 8.971272e-07 |
| STG | NUP42 | exon_skip_53611 | 4.286853e-01 | 1.810454e-05 |
| STG | RALYL | exon_skip_53611 | 6.047448e-01 | 1.367085e-10 |
| STG | SRSF9 | exon_skip_53611 | 4.558971e-01 | 4.385294e-06 |
| STG | RBM3 | exon_skip_289462 | 5.430081e-01 | 2.683934e-08 |
| STG | RALYL | exon_skip_87980 | 4.237941e-01 | 2.559517e-05 |
| STG | MSI1 | exon_skip_92613 | -5.490377e-01 | 1.454704e-08 |
| STG | ILF2 | exon_skip_92613 | 4.018900e-01 | 7.161117e-05 |
| STG | HNRNPK | exon_skip_92613 | 4.051756e-01 | 6.164811e-05 |
| STG | KHDRBS3 | exon_skip_92613 | 4.886131e-01 | 7.755520e-07 |
| STG | HNRNPA0 | exon_skip_92613 | 5.519828e-01 | 1.174007e-08 |
| STG | RALYL | exon_skip_92613 | 6.033428e-01 | 1.949986e-10 |
| STG | PTBP1 | exon_skip_92613 | -5.431869e-01 | 2.213557e-08 |
| TC | RBMS2 | exon_skip_53611 | -5.351326e-01 | 3.100717e-13 |
| TC | SRSF2 | exon_skip_53611 | 5.085473e-01 | 6.627331e-12 |
| TC | KHDRBS2 | exon_skip_53611 | 7.147806e-01 | 2.551572e-26 |
| TC | KHDRBS3 | exon_skip_53611 | 5.937628e-01 | 1.283896e-16 |
| TC | HNRNPD | exon_skip_53611 | 5.332927e-01 | 3.866163e-13 |
| TC | NUP42 | exon_skip_53611 | 6.659106e-01 | 7.426756e-22 |
| TC | RALYL | exon_skip_53611 | 7.479096e-01 | 6.425584e-30 |
| TC | SRSF5 | exon_skip_53611 | 4.262517e-01 | 1.911063e-08 |
| TC | RBMS2 | exon_skip_289462 | -4.275099e-01 | 1.717925e-08 |
| TC | RBM3 | exon_skip_289462 | 6.215228e-01 | 1.791916e-18 |
| TC | HNRNPDL | exon_skip_289462 | 4.189788e-01 | 3.508000e-08 |
| TC | NOVA1 | exon_skip_289462 | 4.644540e-01 | 6.150949e-10 |
| TC | RBM6 | exon_skip_92613 | -4.217043e-01 | 2.798582e-08 |
| TC | ILF2 | exon_skip_92613 | 5.811321e-01 | 7.853270e-16 |
| TC | HNRNPK | exon_skip_92613 | 4.748284e-01 | 2.243292e-10 |
| TC | KHDRBS3 | exon_skip_92613 | 7.053234e-01 | 2.197244e-25 |
| TC | HNRNPA0 | exon_skip_92613 | 7.470345e-01 | 8.130637e-30 |
| TC | NUP42 | exon_skip_92613 | 7.121418e-01 | 4.693600e-26 |
| TC | RALYL | exon_skip_92613 | 8.391347e-01 | 1.235812e-43 |
| TC | PTBP1 | exon_skip_92613 | -4.465591e-01 | 3.242944e-09 |
| TC | PTBP3 | exon_skip_92613 | 5.113741e-01 | 4.845689e-12 |
| TC | CELF1 | exon_skip_92613 | 5.876562e-01 | 3.112101e-16 |
| TC | ESRP1 | exon_skip_92613 | 6.188749e-01 | 2.743097e-18 |
| TC | SART3 | exon_skip_92613 | 4.171316e-01 | 4.083858e-08 |
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RelatedDrugs for PICALM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PICALM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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