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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for RBM10 |
Gene summary |
Gene information | Gene symbol | RBM10 | Gene ID | 8241 |
Gene name | RNA binding motif protein 10 | |
Synonyms | DXS8237E|GPATC9|GPATCH9|S1-1|TARPS|ZRANB5 | |
Cytomap | Xp11.3 | |
Type of gene | protein-coding | |
Description | RNA-binding protein 10RNA-binding protein S1-1epididymis secretory sperm binding proteing patch domain-containing protein 9 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RBM10 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RBM10 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_175077 | chrX | 47173128:47173197:47175019:47175092:47176500:47176586 | 47175019:47175092 |
exon_skip_215102 | chrX | 47145279:47145485:47147357:47147498:47169315:47169498 | 47147357:47147498 |
exon_skip_218916 | chrX | 47179319:47179495:47179684:47179781:47179880:47180037 | 47179684:47179781 |
exon_skip_250505 | chrX | 47179319:47179495:47179880:47180037:47180212:47180309 | 47179880:47180037 |
exon_skip_251472 | chrX | 47179103:47179163:47179319:47179495:47179880:47180037 | 47179319:47179495 |
exon_skip_254717 | chrX | 47181507:47181646:47181749:47181866:47181951:47182042 | 47181749:47181866 |
exon_skip_259903 | chrX | 47179319:47179495:47179880:47180040:47180212:47180309 | 47179880:47180040 |
exon_skip_266413 | chrX | 47181749:47181866:47181951:47182042:47182162:47182326 | 47181951:47182042 |
exon_skip_40169 | chrX | 47185055:47185204:47185302:47185367:47185442:47185630 | 47185302:47185367 |
exon_skip_43174 | chrX | 47169315:47169498:47171028:47171258:47173128:47173197 | 47171028:47171258 |
exon_skip_87650 | chrX | 47180212:47180309:47180419:47180506:47181215:47181401 | 47180419:47180506 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RBM10 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000377604 | 47175019 | 47175092 | Frame-shift |
ENST00000377604 | 47179880 | 47180040 | Frame-shift |
ENST00000377604 | 47180419 | 47180506 | Frame-shift |
ENST00000377604 | 47171028 | 47171258 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000377604 | 47175019 | 47175092 | Frame-shift |
ENST00000377604 | 47171028 | 47171258 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000377604 | 47175019 | 47175092 | Frame-shift |
ENST00000377604 | 47179880 | 47180040 | Frame-shift |
ENST00000377604 | 47180419 | 47180506 | Frame-shift |
ENST00000377604 | 47181749 | 47181866 | Frame-shift |
ENST00000377604 | 47181951 | 47182042 | Frame-shift |
ENST00000377604 | 47171028 | 47171258 | In-frame |
ENST00000377604 | 47179319 | 47179495 | In-frame |
ENST00000377604 | 47185302 | 47185367 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RBM10 |
p-ENSG00000182872_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000377604 | 3764 | 930 | 47171028 | 47171258 | 945 | 1174 | 67 | 144 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000377604 | 3764 | 930 | 47171028 | 47171258 | 945 | 1174 | 67 | 144 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000377604 | 3764 | 930 | 47171028 | 47171258 | 945 | 1174 | 67 | 144 |
ENST00000377604 | 3764 | 930 | 47179319 | 47179495 | 1468 | 1643 | 242 | 300 |
ENST00000377604 | 3764 | 930 | 47185302 | 47185367 | 2844 | 2908 | 700 | 722 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P98175 | 67 | 144 | 68 | 144 | Alternative sequence | ID=VSP_036173;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
P98175 | 67 | 144 | 130 | 134 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI |
P98175 | 67 | 144 | 1 | 930 | Chain | ID=PRO_0000081767;Note=RNA-binding protein 10 |
P98175 | 67 | 144 | 80 | 87 | Compositional bias | Note=Poly-Arg |
P98175 | 67 | 144 | 113 | 125 | Compositional bias | Note=Poly-Glu |
P98175 | 67 | 144 | 129 | 209 | Domain | Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
P98175 | 67 | 144 | 142 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI |
P98175 | 67 | 144 | 89 | 89 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P98175 | 67 | 144 | 68 | 144 | Alternative sequence | ID=VSP_036173;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
P98175 | 67 | 144 | 130 | 134 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI |
P98175 | 67 | 144 | 1 | 930 | Chain | ID=PRO_0000081767;Note=RNA-binding protein 10 |
P98175 | 67 | 144 | 80 | 87 | Compositional bias | Note=Poly-Arg |
P98175 | 67 | 144 | 113 | 125 | Compositional bias | Note=Poly-Glu |
P98175 | 67 | 144 | 129 | 209 | Domain | Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
P98175 | 67 | 144 | 142 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI |
P98175 | 67 | 144 | 89 | 89 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P98175 | 67 | 144 | 68 | 144 | Alternative sequence | ID=VSP_036173;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 |
P98175 | 67 | 144 | 130 | 134 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI |
P98175 | 67 | 144 | 1 | 930 | Chain | ID=PRO_0000081767;Note=RNA-binding protein 10 |
P98175 | 67 | 144 | 80 | 87 | Compositional bias | Note=Poly-Arg |
P98175 | 67 | 144 | 113 | 125 | Compositional bias | Note=Poly-Glu |
P98175 | 67 | 144 | 129 | 209 | Domain | Note=RRM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
P98175 | 67 | 144 | 142 | 152 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LXI |
P98175 | 67 | 144 | 89 | 89 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569 |
P98175 | 242 | 300 | 1 | 930 | Chain | ID=PRO_0000081767;Note=RNA-binding protein 10 |
P98175 | 242 | 300 | 300 | 384 | Domain | Note=RRM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00176 |
P98175 | 242 | 300 | 212 | 242 | Zinc finger | Note=RanBP2-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00322 |
P98175 | 700 | 722 | 1 | 930 | Chain | ID=PRO_0000081767;Note=RNA-binding protein 10 |
P98175 | 700 | 722 | 718 | 718 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:21406692,PMID:24275569 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RBM10 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RBM10 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RBM10 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RBM10 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RBM10 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
DLPFC | RBM6 | exon_skip_175077 | -4.218214e-01 | 6.193526e-15 |
IFG | SFPQ | exon_skip_175077 | -4.389773e-01 | 2.486185e-02 |
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RelatedDrugs for RBM10 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM10 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |