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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZRSR2 |
Gene summary |
Gene information | Gene symbol | ZRSR2 | Gene ID | 8233 |
Gene name | zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 | |
Synonyms | U2AF1-RS2|U2AF1L2|U2AF1RS2|URP|ZC3H22 | |
Cytomap | Xp22.2 | |
Type of gene | protein-coding | |
Description | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2U2(RNU2) small nuclear RNA auxiliary factor 1-like 2U2AF35-related proteinrenal carcinoma antigen N | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZRSR2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZRSR2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_134213 | chrX | 15815677:15815890:15818587:15818642:15820207:15820251 | 15818587:15818642 |
exon_skip_140376 | chrX | 15804113:15804197:15808233:15808271:15809200:15809318 | 15808233:15808271 |
exon_skip_175704 | chrX | 15804183:15804197:15808233:15808271:15809200:15809318 | 15808233:15808271 |
exon_skip_180150 | chrX | 15799883:15799953:15803688:15803796:15804111:15804197 | 15803688:15803796 |
exon_skip_196950 | chrX | 15815677:15815890:15818587:15818642:15820207:15820316 | 15818587:15818642 |
exon_skip_28752 | chrX | 15818587:15818642:15820207:15820316:15822731:15823260 | 15820207:15820316 |
exon_skip_36032 | chrX | 15818592:15818642:15820207:15820316:15822731:15823260 | 15820207:15820316 |
exon_skip_46902 | chrX | 15799872:15799953:15803688:15803796:15804111:15804197 | 15803688:15803796 |
exon_skip_85068 | chrX | 15790934:15791013:15799872:15799953:15803688:15803796 | 15799872:15799953 |
exon_skip_91605 | chrX | 15804111:15804197:15808233:15808271:15809200:15809318 | 15808233:15808271 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZRSR2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000307771 | 15803688 | 15803796 | Frame-shift |
ENST00000307771 | 15818587 | 15818642 | Frame-shift |
ENST00000307771 | 15820207 | 15820316 | Frame-shift |
ENST00000307771 | 15808233 | 15808271 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000307771 | 15803688 | 15803796 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000307771 | 15799872 | 15799953 | Frame-shift |
ENST00000307771 | 15803688 | 15803796 | Frame-shift |
ENST00000307771 | 15818587 | 15818642 | Frame-shift |
ENST00000307771 | 15820207 | 15820316 | Frame-shift |
ENST00000307771 | 15808233 | 15808271 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZRSR2 |
p-ENSG00000169249_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000307771 | 1508 | 482 | 15808233 | 15808271 | 425 | 462 | 133 | 146 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000307771 | 1508 | 482 | 15808233 | 15808271 | 425 | 462 | 133 | 146 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q15696 | 133 | 146 | 1 | 482 | Chain | ID=PRO_0000082001;Note=U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q15696 | 133 | 146 | 1 | 482 | Chain | ID=PRO_0000082001;Note=U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZRSR2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZRSR2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZRSR2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZRSR2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZRSR2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TRA2A | exon_skip_140376 | -5.278319e-01 | 8.719960e-13 |
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RelatedDrugs for ZRSR2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZRSR2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |