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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for LZTR1 |
 Gene summary |
| Gene information | Gene symbol | LZTR1 | Gene ID | 8216 |
| Gene name | leucine zipper like transcription regulator 1 | |
| Synonyms | BTBD29|LZTR-1|NS10|NS2|SWNTS2 | |
| Cytomap | 22q11.21|22q11.1-q11.2 | |
| Type of gene | protein-coding | |
| Description | leucine-zipper-like transcriptional regulator 1epididymis secretory sperm binding protein | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LZTR1 | GO:0016567 | protein ubiquitination | 30442762|30442766 |
| LZTR1 | GO:0046580 | negative regulation of Ras protein signal transduction | 30442762|30442766 |
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Gene structures and expression levels for LZTR1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000099949
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000415817.2 | LZTR1-203:nonsense_mediated_decay:LZTR1 | 1.276751e+02 | -1.508215e+00 | 7.114045e-07 | 1.122352e-05 |
| CB | UP | ENST00000443265.5 | LZTR1-205:nonsense_mediated_decay:LZTR1 | 1.856354e+01 | 1.255443e+00 | 2.864309e-06 | 3.667834e-05 |
| CB | UP | ENST00000644435.1 | LZTR1-219:protein_coding:LZTR1 | 2.114631e+00 | 1.979434e+00 | 6.720477e-04 | 3.699800e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for LZTR1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_287913 | chr22 | 20994915:20995026:20995368:20995484:20995746:20995872 | 20995368:20995484 |
| exon_skip_290821 | chr22 | 20988010:20988118:20988789:20988872:20989625:20989682 | 20988789:20988872 |
| exon_skip_2913 | chr22 | 20983027:20983089:20985841:20985897:20987504:20987583 | 20985841:20985897 |
| exon_skip_37257 | chr22 | 20985841:20985897:20987504:20987583:20988010:20988118 | 20987504:20987583 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for LZTR1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646124 | 20987504 | 20987583 | Frame-shift |
| ENST00000646124 | 20985841 | 20985897 | In-frame |
| ENST00000646124 | 20988789 | 20988872 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646124 | 20987504 | 20987583 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646124 | 20987504 | 20987583 | Frame-shift |
| ENST00000646124 | 20985841 | 20985897 | In-frame |
| ENST00000646124 | 20988789 | 20988872 | In-frame |
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Infer the effects of exon skipping event on protein functional features for LZTR1 |
p-ENSG00000099949_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646124 | 4298 | 840 | 20985841 | 20985897 | 339 | 394 | 88 | 106 |
| ENST00000646124 | 4298 | 840 | 20988789 | 20988872 | 585 | 667 | 170 | 197 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646124 | 4298 | 840 | 20985841 | 20985897 | 339 | 394 | 88 | 106 |
| ENST00000646124 | 4298 | 840 | 20988789 | 20988872 | 585 | 667 | 170 | 197 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N653 | 88 | 106 | 2 | 840 | Chain | ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1 |
| Q8N653 | 88 | 106 | 79 | 128 | Repeat | Note=Kelch 1 |
| Q8N653 | 170 | 197 | 2 | 840 | Chain | ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1 |
| Q8N653 | 170 | 197 | 130 | 185 | Repeat | Note=Kelch 2 |
| Q8N653 | 170 | 197 | 187 | 238 | Repeat | Note=Kelch 3 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N653 | 88 | 106 | 2 | 840 | Chain | ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1 |
| Q8N653 | 88 | 106 | 79 | 128 | Repeat | Note=Kelch 1 |
| Q8N653 | 170 | 197 | 2 | 840 | Chain | ID=PRO_0000119135;Note=Leucine-zipper-like transcriptional regulator 1 |
| Q8N653 | 170 | 197 | 130 | 185 | Repeat | Note=Kelch 2 |
| Q8N653 | 170 | 197 | 187 | 238 | Repeat | Note=Kelch 3 |
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3'-UTR located exon skipping events that lost miRNA binding sites in LZTR1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for LZTR1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for LZTR1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LZTR1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for LZTR1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_37257 | 4.288993e-01 | 1.881909e-08 |
| TC | SRSF2 | exon_skip_37257 | -4.437051e-01 | 5.875785e-09 |
| TC | SRSF5 | exon_skip_37257 | -4.087919e-01 | 1.064723e-07 |
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RelatedDrugs for LZTR1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LZTR1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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