|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for CANX |
 Gene summary |
| Gene information | Gene symbol | CANX | Gene ID | 821 |
| Gene name | calnexin | |
| Synonyms | CNX|IP90|P90 | |
| Cytomap | 5q35.3 | |
| Type of gene | protein-coding | |
| Description | calnexinepididymis secretory sperm binding proteinmajor histocompatibility complex class I antigen-binding protein p88 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for CANX |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000127022
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000504579.5 | CANX-208:nonsense_mediated_decay:CANX | 1.145310e+01 | 1.569437e+00 | 2.460514e-04 | 1.586656e-03 |
| TC | UP | ENST00000513246.5 | CANX-217:protein_coding:CANX | 3.084106e+00 | 8.054466e-01 | 7.119713e-05 | 1.234850e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CANX |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100386 | chr5 | 179699026:179699102:179699575:179699770:179705679:179705777 | 179699575:179699770 |
| exon_skip_105162 | chr5 | 179708978:179709059:179709873:179710065:179716105:179716201 | 179709873:179710065 |
| exon_skip_150961 | chr5 | 179705786:179705852:179706258:179706331:179708239:179708273 | 179706258:179706331 |
| exon_skip_16218 | chr5 | 179708338:179708380:179708978:179709059:179709873:179709949 | 179708978:179709059 |
| exon_skip_168036 | chr5 | 179699080:179699102:179705679:179705852:179706258:179706331 | 179705679:179705852 |
| exon_skip_168203 | chr5 | 179708287:179708380:179708978:179709059:179709873:179709949 | 179708978:179709059 |
| exon_skip_183273 | chr5 | 179699026:179699102:179704155:179704430:179705679:179705852 | 179704155:179704430 |
| exon_skip_193105 | chr5 | 179699026:179699102:179704155:179704430:179705679:179705777 | 179704155:179704430 |
| exon_skip_201891 | chr5 | 179716105:179716294:179719668:179719781:179720404:179720494 | 179719668:179719781 |
| exon_skip_228143 | chr5 | 179698977:179699102:179704155:179704430:179705679:179705715 | 179704155:179704430 |
| exon_skip_228270 | chr5 | 179699026:179699102:179705679:179705852:179708239:179708256 | 179705679:179705852 |
| exon_skip_260816 | chr5 | 179722804:179723019:179723660:179723779:179724657:179724710 | 179723660:179723779 |
| exon_skip_265049 | chr5 | 179724657:179724783:179726680:179726759:179728591:179728682 | 179726680:179726759 |
| exon_skip_278855 | chr5 | 179705679:179705852:179706258:179706331:179708239:179708256 | 179706258:179706331 |
| exon_skip_289240 | chr5 | 179720488:179720560:179722804:179723019:179723660:179723779 | 179722804:179723019 |
| exon_skip_291311 | chr5 | 179720511:179720560:179722804:179723019:179723660:179723779 | 179722804:179723019 |
| exon_skip_32916 | chr5 | 179699026:179699102:179705679:179705852:179706258:179706322 | 179705679:179705852 |
| exon_skip_61168 | chr5 | 179720404:179720560:179722804:179723019:179723660:179723779 | 179722804:179723019 |
| exon_skip_69183 | chr5 | 179706307:179706331:179707132:179707190:179708239:179708256 | 179707132:179707190 |
| exon_skip_84941 | chr5 | 179723660:179723779:179724657:179724783:179726680:179726735 | 179724657:179724783 |
| exon_skip_85265 | chr5 | 179698977:179699102:179704155:179704430:179705679:179705852 | 179704155:179704430 |
| exon_skip_98031 | chr5 | 179708978:179709059:179709919:179710065:179716105:179716201 | 179709919:179710065 |
| exon_skip_99491 | chr5 | 179699026:179699102:179705679:179705852:179706258:179706331 | 179705679:179705852 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CANX |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
Top |
Infer the effects of exon skipping event on protein functional features for CANX |
p-ENSG00000127022_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in CANX |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for CANX |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for CANX |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CANX |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for CANX |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for CANX |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P27824 | approved|investigational | DB00025 | Antihemophilic factor, human recombinant | biotech | P27824 |
| P27824 | approved | DB00031 | Tenecteplase | biotech | P27824 |
| P27824 | approved|investigational | DB11093 | Calcium Citrate | small molecule | P27824 |
| P27824 | approved | DB11348 | Calcium Phosphate | small molecule | P27824 |
Top |
RelatedDiseases for CANX |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|