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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for NRIP1 |
Gene summary |
Gene information | Gene symbol | NRIP1 | Gene ID | 8204 |
Gene name | nuclear receptor interacting protein 1 | |
Synonyms | CAKUT3|RIP140 | |
Cytomap | 21q11.2-q21.1 | |
Type of gene | protein-coding | |
Description | nuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
NRIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10364267 |
NRIP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7641693|10364267 |
NRIP1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
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Gene structures and expression levels for NRIP1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NRIP1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_165832 | chr21 | 14961235:14968526:15014344:15014466:15043495:15043574 | 15014344:15014466 |
exon_skip_230855 | chr21 | 15014344:15014466:15043495:15043574:15064745:15065000 | 15043495:15043574 |
exon_skip_276810 | chr21 | 14961235:14968526:15014344:15014466:15043495:15043570 | 15014344:15014466 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NRIP1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000318948 | 15014344 | 15014466 | 3UTR-3UTR |
ENST00000318948 | 15043495 | 15043574 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000318948 | 15014344 | 15014466 | 3UTR-3UTR |
ENST00000318948 | 15043495 | 15043574 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000318948 | 15014344 | 15014466 | 3UTR-3UTR |
ENST00000318948 | 15043495 | 15043574 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for NRIP1 |
p-ENSG00000180530_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NRIP1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000318948 | 15043495 | 15043574 | hsa-miR-205-3p | chr21:15043547-15043554 | 8mer-1a | chr21:15043535-15043556 | 153.00 | -13.75 |
Mayo | ENST00000318948 | 15043495 | 15043574 | hsa-miR-3664-3p | chr21:15043533-15043540 | 8mer-1a | chr21:15043521-15043544 | 154.00 | -15.40 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-3913-3p | chr21:15014414-15014421 | 8mer-1a | chr21:15014407-15014425 | 159.00 | -21.76 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-4439 | chr21:15014451-15014458 | 8mer-1a | chr21:15014434-15014458 | 160.00 | -22.31 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-8064 | chr21:15014458-15014465 | 8mer-1a | chr21:15014445-15014465 | 149.00 | -17.26 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-3136-5p | chr21:15014451-15014458 | 8mer-1a | chr21:15014434-15014458 | 160.00 | -22.31 |
Mayo | ENST00000318948 | 15043495 | 15043574 | hsa-miR-302c-5p | chr21:15043517-15043524 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-1305 | chr21:15014399-15014406 | 8mer-1a | chr21:15014389-15014409 | 145.00 | -10.73 |
Mayo | ENST00000318948 | 15043495 | 15043574 | hsa-miR-887-5p | chr21:15043510-15043517 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-5003-3p | chr21:15014402-15014409 | 8mer-1a | chr21:15014401-15014422 | 156.00 | -14.48 |
Mayo | ENST00000318948 | 15043495 | 15043574 | hsa-miR-3143 | chr21:15043516-15043523 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
Mayo | ENST00000318948 | 15043495 | 15043574 | hsa-miR-5004-3p | chr21:15043561-15043568 | 8mer-1a | chr21:15043547-15043568 | 142.00 | -14.03 |
Mayo | ENST00000318948 | 15014344 | 15014466 | hsa-miR-421 | chr21:15014397-15014404 | 8mer-1a | chr21:15014380-15014404 | 152.00 | -12.69 |
MSBB | ENST00000318948 | 15043495 | 15043574 | hsa-miR-205-3p | chr21:15043547-15043554 | 8mer-1a | chr21:15043535-15043556 | 153.00 | -13.75 |
MSBB | ENST00000318948 | 15043495 | 15043574 | hsa-miR-3664-3p | chr21:15043533-15043540 | 8mer-1a | chr21:15043521-15043544 | 154.00 | -15.40 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-3913-3p | chr21:15014414-15014421 | 8mer-1a | chr21:15014407-15014425 | 159.00 | -21.76 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-4439 | chr21:15014451-15014458 | 8mer-1a | chr21:15014434-15014458 | 160.00 | -22.31 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-8064 | chr21:15014458-15014465 | 8mer-1a | chr21:15014445-15014465 | 149.00 | -17.26 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-3136-5p | chr21:15014451-15014458 | 8mer-1a | chr21:15014434-15014458 | 160.00 | -22.31 |
MSBB | ENST00000318948 | 15043495 | 15043574 | hsa-miR-302c-5p | chr21:15043517-15043524 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-1305 | chr21:15014399-15014406 | 8mer-1a | chr21:15014389-15014409 | 145.00 | -10.73 |
MSBB | ENST00000318948 | 15043495 | 15043574 | hsa-miR-887-5p | chr21:15043510-15043517 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-5003-3p | chr21:15014402-15014409 | 8mer-1a | chr21:15014401-15014422 | 156.00 | -14.48 |
MSBB | ENST00000318948 | 15043495 | 15043574 | hsa-miR-3143 | chr21:15043516-15043523 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
MSBB | ENST00000318948 | 15043495 | 15043574 | hsa-miR-5004-3p | chr21:15043561-15043568 | 8mer-1a | chr21:15043547-15043568 | 142.00 | -14.03 |
MSBB | ENST00000318948 | 15014344 | 15014466 | hsa-miR-421 | chr21:15014397-15014404 | 8mer-1a | chr21:15014380-15014404 | 152.00 | -12.69 |
ROSMAP | ENST00000318948 | 15043495 | 15043574 | hsa-miR-205-3p | chr21:15043547-15043554 | 8mer-1a | chr21:15043535-15043556 | 153.00 | -13.75 |
ROSMAP | ENST00000318948 | 15043495 | 15043574 | hsa-miR-3664-3p | chr21:15043533-15043540 | 8mer-1a | chr21:15043521-15043544 | 154.00 | -15.40 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-3913-3p | chr21:15014414-15014421 | 8mer-1a | chr21:15014407-15014425 | 159.00 | -21.76 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-4439 | chr21:15014451-15014458 | 8mer-1a | chr21:15014434-15014458 | 160.00 | -22.31 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-8064 | chr21:15014458-15014465 | 8mer-1a | chr21:15014445-15014465 | 149.00 | -17.26 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-3136-5p | chr21:15014451-15014458 | 8mer-1a | chr21:15014434-15014458 | 160.00 | -22.31 |
ROSMAP | ENST00000318948 | 15043495 | 15043574 | hsa-miR-302c-5p | chr21:15043517-15043524 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-1305 | chr21:15014399-15014406 | 8mer-1a | chr21:15014389-15014409 | 145.00 | -10.73 |
ROSMAP | ENST00000318948 | 15043495 | 15043574 | hsa-miR-887-5p | chr21:15043510-15043517 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-5003-3p | chr21:15014402-15014409 | 8mer-1a | chr21:15014401-15014422 | 156.00 | -14.48 |
ROSMAP | ENST00000318948 | 15043495 | 15043574 | hsa-miR-3143 | chr21:15043516-15043523 | 8mer-1a | chr21:15043501-15043524 | 152.00 | -17.64 |
ROSMAP | ENST00000318948 | 15043495 | 15043574 | hsa-miR-5004-3p | chr21:15043561-15043568 | 8mer-1a | chr21:15043547-15043568 | 142.00 | -14.03 |
ROSMAP | ENST00000318948 | 15014344 | 15014466 | hsa-miR-421 | chr21:15014397-15014404 | 8mer-1a | chr21:15014380-15014404 | 152.00 | -12.69 |
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SNVs in the skipped exons for NRIP1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NRIP1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NRIP1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NRIP1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TIA1 | exon_skip_165832 | 5.293857e-01 | 1.851093e-10 |
CB | TRA2A | exon_skip_165832 | -5.309542e-01 | 1.599248e-10 |
CB | FUBP1 | exon_skip_165832 | -4.505979e-01 | 1.194149e-07 |
CB | RBM45 | exon_skip_165832 | 7.317247e-01 | 2.211870e-22 |
CB | NUP42 | exon_skip_165832 | 6.471468e-01 | 2.672564e-16 |
CB | PTBP1 | exon_skip_165832 | -4.325510e-01 | 4.233764e-07 |
HCC | ENOX1 | exon_skip_276810 | -4.011919e-01 | 7.506202e-11 |
HCC | PTBP1 | exon_skip_276810 | -4.177044e-01 | 1.011335e-11 |
IFG | BOLL | exon_skip_165832 | -6.211724e-01 | 1.197325e-03 |
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RelatedDrugs for NRIP1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRIP1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |